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BIOCARTA_P53HYPOXIA_PATHWAY
(Pathway_759)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
RPA1 6 0.500 0.350 3.133 3.046 0.303 1.770 2.112
HSP90AA1 3 -0.150 0.150 0.395 1.024 -1.280 0.611 0.460
HSP90AA1 3 0.170 -0.420 0.395 1.024 -1.280 0.611 0.460
ABCB1 2 -2.060 4.670 2.195
CSNK1A1 1 0.080 -0.140 2.048 -0.562 0.195 -0.389 0.187
BAX 0 1.590 -1.170 0.811 0.359
EP300 0 -1.210 1.320 -1.089 -1.694 -0.723
HIF1A 0 -0.480 0.400
GADD45A 0 1.050 -0.170
CDKN1A 0 1.080 -0.750
MDM2 0 -0.210 0.080
TP53 0 -1.070 1.050 -2.808 0.076 -0.094 0.436 0.497
CSNK1D 0 0.340 -0.060 0.150 0.527
CSNK1D 0 0.340 -0.060
CSNK1D 0 0.340 -0.060 1.237 -0.682 -0.148
AKT1 0 -0.050 0.700
AKT1 0 0.860 -0.040
TAF1 0 0.381 0.385
ATM 0 0.398 0.474

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ABCB1 Ubiquitylation K271 1.459 _TVIAFGGQK(gl)K_
ABCB1 Ubiquitylation K272 1.009 _TVIAFGGQKK(gl)_
ABCB1 Ubiquitylation K279 -0.087 0.047 _YNK(gl)NLEEAKR_
ABCB1 Ubiquitylation K617 0.890 _GNHDELMK(gl)EK_
ABCB1 Ubiquitylation K826 -0.613 0.002 _LANDAAQVK(gl)GAIGSR_
ABCB1 Ubiquitylation K1093 -1.090 _FYDPLAGK(gl)VLLDGK_
AKT1 Phosphorylation S124 0.252 0.311 _SGS(ph)PSDNSGAEEMEVSLAKPK_
AKT1 Phosphorylation S126 -0.241 _SGSPS(ph)DNSGAEEM(ox)EVSLAK_
AKT1 Ubiquitylation K301 0.988 _EGIK(gl)DGATMK_
ATM Ubiquitylation K307 -0.196 _GAYESTK(gl)WR_
ATM Ubiquitylation K331 -0.126 _GK(gl)YSSGFR_
ATM Ubiquitylation K385 -0.669 _ESSDYSVPCK(gl)R_
ATM Ubiquitylation K1101 -0.548 _LFQDTK(gl)GDSSR_
ATM Ubiquitylation K1109 -1.666 _LLK(gl)ALPLK_
ATM Ubiquitylation K1698 -1.026 _DASYTK(gl)ALK_
ATM Ubiquitylation K1738 -0.137 _SAAVTCLK(gl)NILATK_
ATM Ubiquitylation K2025 -1.497 _SIGEPDSLYGCGGGK(gl)MLQPITR_
BAX Ubiquitylation K57 -1.174 _MGGEAPELALDPVPQDASTK(gl)K_
BAX Ubiquitylation K58 -1.718 -1.174 _MGGEAPELALDPVPQDASTKK(gl)_
BAX Ubiquitylation K64 0.708 1.306 _LSECLK(gl)R_
CDKN1A Ubiquitylation K188 -2.505 -1.077 _QTSMTDFYHSK(gl)R_
CSNK1A1 Ubiquitylation K8 -0.342 -0.408 _(ac)ASSSGSK(gl)AEFIVGGK_
CSNK1A1 Ubiquitylation K18 0.772 _AEFIVGGKYK(gl)_
CSNK1A1 Ubiquitylation K225 0.039 0.502 _TSLPWQGLK(gl)AATK_
CSNK1A1 Ubiquitylation K304 -0.489 0.015 _QK(gl)AAQQAASSSGQGQQAQTPTGK_
CSNK1D Ubiquitylation K43 -1.168 _LECVK(gl)TK_
CSNK1D Ubiquitylation K45 -1.168 _LECVK(gl)TK_
CSNK1D Ubiquitylation K140 -0.969 _DVKPDNFLMGLGK(gl)K_
CSNK1D Ubiquitylation K141 -0.969 -0.720 _DVKPDNFLMGLGKK(gl)_
CSNK1D Phosphorylation S350 -0.790 _LRGTQEVAPPTPLTPTS(ph)HTANTSPRPVSGM(ox)ER_
CSNK1D Phosphorylation S363 -0.662 -0.352 _IQPAGNTS(ph)PR_
CSNK1D Phosphorylation S382 -0.647 -0.568 _GAPVNIS(ph)SSDLTGR_
CSNK1D Phosphorylation S389 0.394 0.817 _GAPANVS(ph)SSDLTGR_
EP300 Phosphorylation S1038 -0.672 -0.349 _TEIKEEEDQPSTSATQSS(ph)PAPGQSK_
EP300 Phosphorylation S1726 0.994 0.627 _LGLGLDDESNNQQAAATQS(ph)PGDSRR_
EP300 Phosphorylation S2328 -1.092 0.725 _PQSQPPHSSPS(ph)PR_
GADD45A Ubiquitylation K12 -0.515 0.281 _TLEEFSAGEQK(gl)TER_
GADD45A Ubiquitylation K29 0.092 _VGDALEEVLSK(gl)ALSQR_
HIF1A Ubiquitylation K10 -1.686 _(ac)MEGAGGANDK(gl)K_
HIF1A Ubiquitylation K11 -1.686 _(ac)MEGAGGANDK(gl)K_
HIF1A Ubiquitylation K173 -0.662 _MK(gl)CTLTSR_
HIF1A Ubiquitylation K186 -0.590 _TMNIK(gl)SATWK_
HIF1A Ubiquitylation K252 -0.784 _HSLDM(ox)K(gl)FSYCDER_
HIF1A Ubiquitylation K371 -0.508 _PVESSDMK(gl)MTQLFTK_
HIF1A Ubiquitylation K378 -0.077 _MTQLFTK(gl)VESEDTSSLFDK_
HIF1A Ubiquitylation K390 -0.348 _VESEDTSSLFDK(gl)LKK_
HIF1A Ubiquitylation K392 -0.546 _VESEDTSSLFDKLK(gl)_
HIF1A Ubiquitylation K393 -0.451 _VESEDTSSLFDKLKK(gl)_
HIF1A Ubiquitylation K710 -1.696 _TTVPEEELNPK(gl)ILALQNAQR_
HSP90AA1 Ubiquitylation K69 0.820 -0.090 _YESLTDPSK(gl)LDSGK_
HSP90AA1 Ubiquitylation K74 0.543 _LDSGK(gl)ELHINLIPNKQDR_
HSP90AA1 Ubiquitylation K112 1.304 1.601 _ADLINNLGTIAK(gl)SGTK_
HSP90AA1 Ubiquitylation K185 0.963 _GTK(gl)VILHLK_
HSP90AA1 Ubiquitylation K208 1.745 _IKEIVK(gl)K_
HSP90AA1 Phosphorylation S231 2.338 0.649 _DKEVS(ph)DDEAEEK_
HSP90AA1 Phosphorylation S263 0.095 0.173 _ESEDKPEIEDVGS(ph)DEEEEKK_
HSP90AA1 Ubiquitylation K281 1.267 _IK(gl)EKYIDQEELNK_
HSP90AA1 Ubiquitylation K283 1.442 1.226 _EK(gl)YIDQEELNK_
HSP90AA1 Ubiquitylation K292 -0.237 0.506 _YIDQEELNK(gl)TKPIWTR_
HSP90AA1 Ubiquitylation K294 0.315 8.646 _TK(gl)PIWTR_
HSP90AA1 Ubiquitylation K362 0.969 0.946 _NNIK(gl)LYVR_
HSP90AA1 Ubiquitylation K407 0.827 1.121 _EMLQQSK(gl)ILK_
HSP90AA1 Ubiquitylation K443 0.820 0.951 _FYEQFSK(gl)NIK_
HSP90AA1 Ubiquitylation K446 0.314 1.126 _NIK(gl)LGIHEDSQNR_
HSP90AA1 Ubiquitylation K478 0.799 1.624 _YYTSASGDEM(ox)VSLK(gl)DYCTR_
HSP90AA1 Ubiquitylation K539 0.353 1.775 _EFEGK(gl)TLVSVTK_
HSP90AA1 Ubiquitylation K559 -0.316 _EGLELPEDEEEKK(gl)K_
HSP90AA1 Ubiquitylation K565 0.903 _K(gl)TKFENLCK_
HSP90AA1 Ubiquitylation K567 0.710 _TK(gl)FENLCK_
HSP90AA1 Ubiquitylation K576 0.874 _IMK(gl)DILEK_
HSP90AA1 Ubiquitylation K581 0.540 0.738 _DILEK(gl)KVEK_
HSP90AA1 Ubiquitylation K582 0.063 0.470 _K(gl)VEKVVVSNR_
HSP90AA1 Ubiquitylation K615 0.715 0.751 _IMK(gl)AQALR_
HSP90AA1 Ubiquitylation K631 0.361 0.974 _DNSTMGYMAAK(gl)K_
MDM2 Phosphorylation S166 0.576 1.068 _AIS(ph)ETEENSDELSGER_
MDM2 Ubiquitylation K334 -0.872 _ENWLPEDK(gl)GK_
MDM2 Ubiquitylation K336 -0.872 _ENWLPEDK(gl)GK_
MDM2 Ubiquitylation K363 0.883 _LENSTQAEEGFDVPDCK(gl)K_
MDM2 Ubiquitylation K364 0.883 _LENSTQAEEGFDVPDCK(gl)K_
MDM2 Ubiquitylation K473 0.806 _NK(gl)PCPVCR_
RPA1 Ubiquitylation K163 2.827 4.085 _AYGASK(gl)TFGK_
RPA1 Ubiquitylation K167 3.009 3.243 _TFGK(gl)AAGPSLSHTSGGTQSK_
RPA1 Ubiquitylation K183 0.925 _AAGPSLSHTSGGTQSK(gl)VVPIASLTPYQSK_
RPA1 Ubiquitylation K263 -1.803 _GTLK(gl)IANK_
RPA1 Ubiquitylation K267 2.751 _IANK(gl)QFTAVK_
RPA1 Ubiquitylation K331 3.112 4.066 _SYEDATK(gl)ITVR_
RPA1 Ubiquitylation K410 2.458 _SLSVLSSSTIIANPDIPEAYK(gl)LR_
RPA1 Ubiquitylation K489 0.465 2.335 _K(gl)VIDQQNGLYR_
RPA1 Ubiquitylation K588 -0.055 _IK(gl)ATVMDVKPVDYR_
RPA1 Ubiquitylation K595 1.201 _ATVMDVK(gl)PVDYR_
TAF1 Phosphorylation S547 -1.176 _LLEPPVLTLDPNDENLILEIPDEKEEATSNSPS(ph)K_
TAF1 Phosphorylation S550 -1.343 _LLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKES(ph)K_
TAF1 Phosphorylation S1176 0.662 1.114 _DDDTASVTS(ph)LNSSATGR_
TAF1 Phosphorylation T1703 0.001 -0.298 _DASVFQDESNM(ox)SVLDIPSAT(ph)PEK_
TP53 Ubiquitylation K120 -0.188 _LGFLHSGTAK(gl)SVTCTYSPALNK_
TP53 Ubiquitylation K164 0.157 -1.260 _AMAIYK(gl)QSQHMTEVVR_
TP53 Phosphorylation S314 -0.695 -1.000 _ALPNNTSS(ph)SPQPK_
TP53 Phosphorylation S315 -0.762 -0.959 _RALPNNTSSS(ph)PQPK_
TP53 Ubiquitylation K320 -0.978 _ALPNNTSSSPQPKK(gl)_
TP53 Ubiquitylation K357 -0.231 -0.823 _ELNEALELKDAQAGK(gl)EPGGSR_


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