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Query: HSP90AA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HSP90AA1 3 15.867 -0.150 0.150 0.395 1.024 -1.280 0.611 0.460
HSP90AA1 3 15.867 0.170 -0.420 0.395 1.024 -1.280 0.611 0.460

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HSP90AA1 Ubiquitylation K294 0.315 8.646 _TK(gl)PIWTR_
HSP90AA1 Ubiquitylation K539 0.353 1.775 _EFEGK(gl)TLVSVTK_
HSP90AA1 Ubiquitylation K478 0.799 1.624 _YYTSASGDEM(ox)VSLK(gl)DYCTR_
HSP90AA1 Ubiquitylation K112 1.304 1.601 _ADLINNLGTIAK(gl)SGTK_
HSP90AA1 Ubiquitylation K283 1.442 1.226 _EK(gl)YIDQEELNK_
HSP90AA1 Ubiquitylation K446 0.314 1.126 _NIK(gl)LGIHEDSQNR_
HSP90AA1 Ubiquitylation K407 0.827 1.121 _EMLQQSK(gl)ILK_
HSP90AA1 Ubiquitylation K631 0.361 0.974 _DNSTMGYMAAK(gl)K_
HSP90AA1 Ubiquitylation K443 0.820 0.951 _FYEQFSK(gl)NIK_
HSP90AA1 Ubiquitylation K362 0.969 0.946 _NNIK(gl)LYVR_
HSP90AA1 Ubiquitylation K615 0.715 0.751 _IMK(gl)AQALR_
HSP90AA1 Ubiquitylation K581 0.540 0.738 _DILEK(gl)KVEK_
HSP90AA1 Phosphorylation S231 2.338 0.649 _DKEVS(ph)DDEAEEK_
HSP90AA1 Ubiquitylation K292 -0.237 0.506 _YIDQEELNK(gl)TKPIWTR_
HSP90AA1 Ubiquitylation K582 0.063 0.470 _K(gl)VEKVVVSNR_
HSP90AA1 Phosphorylation S263 0.095 0.173 _ESEDKPEIEDVGS(ph)DEEEEKK_
HSP90AA1 Ubiquitylation K69 0.820 -0.090 _YESLTDPSK(gl)LDSGK_
HSP90AA1 Ubiquitylation K74 0.543 _LDSGK(gl)ELHINLIPNKQDR_
HSP90AA1 Ubiquitylation K185 0.963 _GTK(gl)VILHLK_
HSP90AA1 Ubiquitylation K208 1.745 _IKEIVK(gl)K_
HSP90AA1 Ubiquitylation K281 1.267 _IK(gl)EKYIDQEELNK_
HSP90AA1 Ubiquitylation K559 -0.316 _EGLELPEDEEEKK(gl)K_
HSP90AA1 Ubiquitylation K565 0.903 _K(gl)TKFENLCK_
HSP90AA1 Ubiquitylation K567 0.710 _TK(gl)FENLCK_
HSP90AA1 Ubiquitylation K576 0.874 _IMK(gl)DILEK_

Background Information for HSP90AA1:


Pubmed-HSP90AA1 »
Uniprot-HSP90AA1 »
Biogrid-HSP90AA1 »
ProteomicsDB-HSP90AA1 »

Tumorportal-HSP90AA1 »
COSMIC-HSP90AA1 »
GenomeRNAi-HSP90AA1 »
Genecards-HSP90AA1


Protein-protein Interactions for HSP90AA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC37 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHORDC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSP90AA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IKBKG Cat. description Hein, Mann, Cell 2015
Category members IP bait LRR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait NES Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP5C Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AKT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ANKMY2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AURKB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AURKC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BTK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC117 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK11A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDKL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDKL4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF2C3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FKBP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FYN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GBP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYLK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDIK1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMYD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STK11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STK35 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HSP90AA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Hsp90_fam IPR001404 1.09
Category members Hsp90_N IPR020575 1.09
Category members HATPase_C IPR003594 1.07
Category members Ribosomal_S5_D2-typ_fold IPR020568 1.06


Protein complexes (CORUM database) featuring HSP90AA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5266 TNF-alpha/NF-kappa B signaling complex 6 Database 3.74
Category members Corum 5199 Kinase maturation complex 1 Database 3.38
Category members Corum 5268 TNF-alpha/NF-kappa B signaling complex 7 Database 1.75
Category members Corum 5269 TNF-alpha/NF-kappa B signaling complex 8 Database 1.36
Category members Corum 5234 IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex Database 0.57
Category members Corum 2112 CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex Database 0.36
Category members Corum 5212 Kinase maturation complex 2 Database 0.18
Category members Corum 5286 TNF-alpha/NF-kappa B signaling complex 10 Database 0.18
Category members Corum 5718 eNOS-HSP90-AKT complex, VEGF induced Database 0.07
Category members Corum 5622 HSP90-CIP1-FKBPL complex Database 0
Category members Corum 5716 eNOS-HSP90 complex, VEGF induced Database 0


Categories featuring HSP90AA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_369 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION 0 INF
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006457 protein folding Database 4.93
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members Pathway Pathway_934 PID_PI3KCI_AKT_PATHWAY 0 2.5
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members Pathway Pathway_1147 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION 0 1.89
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members Pathway Pathway_366 BIOCARTA_TEL_PATHWAY 0 1.44
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members GO Category GO:0032564 dATP binding Database 1.31
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members Pathway Pathway_583 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR 0 0.68
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0017098 sulfonylurea receptor binding Database 0.65
Category members GO Category GO:0042026 protein refolding Database 0.63
Category members GO Category GO:0006986 response to unfolded protein Database 0.62
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members GO Category GO:0045040 protein import into mitochondrial outer membrane Database 0.54
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members Pathway Pathway_542 BIOCARTA_AKT_PATHWAY 0 0.45
Category members GO Category GO:0031012 extracellular matrix Database 0.45
Category members Pathway Pathway_728 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 0 0.4
Category members GO Category GO:0043627 response to estrogen Database 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0002135 CTP binding Database 0.37
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis Database 0.33
Category members Pathway Pathway_730 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 0 0.33
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0010592 positive regulation of lamellipodium assembly Database 0.31
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members Pathway Pathway_1143 PID_HDAC_CLASSII_PATHWAY 0 0.3
Category members GO Category GO:0030235 nitric-oxide synthase regulator activity Database 0.28
Category members GO Category GO:0030911 TPR domain binding Database 0.27
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_1053 KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members GO Category GO:0051131 chaperone-mediated protein complex assembly Database 0.24
Category members Pathway Pathway_759 BIOCARTA_P53HYPOXIA_PATHWAY 0 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0002134 UTP binding Database 0.14
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_767 KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 0 0.09
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0045429 positive regulation of nitric oxide biosynthetic process Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0009651 response to salt stress Database 0.04
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members GO Category GO:0033160 positive regulation of protein import into nucleus, translocation Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members Pathway Pathway_521 PID_AVB3_INTEGRIN_PATHWAY 0 0.03
Category members Pathway Pathway_1068 PID_ERBB_NETWORK_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_301 BIOCARTA_NO1_PATHWAY 0 0
Category members Pathway Pathway_407 BIOCARTA_HIF_PATHWAY 0 0
Category members Pathway Pathway_431 PID_VEGFR1_PATHWAY 0 0
Category members Pathway Pathway_435 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION 0 0
Category members Pathway Pathway_438 REACTOME_ENOS_ACTIVATION_AND_REGULATION 0 0
Category members Pathway Pathway_439 BIOCARTA_GCR_PATHWAY 0 0
Category members Pathway Pathway_502 PID_PI3KCI_PATHWAY 0 0
Category members Pathway Pathway_585 PID_IL2_PI3K_PATHWAY 0 0
Category members Pathway Pathway_976 PID_HIF1A_PATHWAY 0 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0003009 skeletal muscle contraction Database 0
Category members GO Category GO:0006839 mitochondrial transport Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0009408 response to heat Database 0
Category members GO Category GO:0010659 cardiac muscle cell apoptotic process Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0031526 brush border membrane Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0045793 positive regulation of cell size Database 0
Category members GO Category GO:0046209 nitric oxide metabolic process Database 0
Category members GO Category GO:0050999 regulation of nitric-oxide synthase activity Database 0
Category members GO Category GO:0060452 positive regulation of cardiac muscle contraction Database 0


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