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Query: ABCB1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ABCB1 2 9.213 -2.060 4.670 2.195

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ABCB1 Ubiquitylation K271 1.459 _TVIAFGGQK(gl)K_
ABCB1 Ubiquitylation K272 1.009 _TVIAFGGQKK(gl)_
ABCB1 Ubiquitylation K279 -0.087 0.047 _YNK(gl)NLEEAKR_
ABCB1 Ubiquitylation K826 -0.613 0.002 _LANDAAQVK(gl)GAIGSR_
ABCB1 Ubiquitylation K617 0.890 _GNHDELMK(gl)EK_
ABCB1 Ubiquitylation K1093 -1.090 _FYDPLAGK(gl)VLLDGK_

Background Information for ABCB1:


Pubmed-ABCB1 »
Uniprot-ABCB1 »
Biogrid-ABCB1 »
ProteomicsDB-ABCB1 »

Tumorportal-ABCB1 »
COSMIC-ABCB1 »
GenomeRNAi-ABCB1 »
Genecards-ABCB1


Protein-protein Interactions for ABCB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LGALS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ABCB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members AAA+_ATPase IPR003593 0.38
Category members ABC1_TM_dom IPR011527 0.33
Category members ABC_ATPase_put IPR019195 0.32
Category members ABC_transporter-like IPR003439 0.15
Category members ABC_transptr_TM_dom IPR001140 0.06


Protein complexes (CORUM database) featuring ABCB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ABCB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members Pathway Pathway_759 BIOCARTA_P53HYPOXIA_PATHWAY 0 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0046581 intercellular canaliculus Database 0.15
Category members Pathway Pathway_756 KEGG_ABC_TRANSPORTERS 0 0.13
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0042626 ATPase activity, coupled to transmembrane movement of substances Database 0.09
Category members Pathway Pathway_38 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM 0 0.08
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members GO Category GO:0008559 xenobiotic-transporting ATPase activity Database 0.05
Category members Pathway Pathway_451 BIOCARTA_NUCLEARRS_PATHWAY 0 0
Category members Pathway Pathway_758 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0005215 transporter activity Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0006855 drug transmembrane transport Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0


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