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Query: TP53

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TP53 0 -3.163 -1.070 1.050 -2.808 0.076 -0.094 0.436 0.497

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TP53 Ubiquitylation K357 -0.231 -0.823 _ELNEALELKDAQAGK(gl)EPGGSR_
TP53 Phosphorylation S315 -0.762 -0.959 _RALPNNTSSS(ph)PQPK_
TP53 Phosphorylation S314 -0.695 -1.000 _ALPNNTSS(ph)SPQPK_
TP53 Ubiquitylation K164 0.157 -1.260 _AMAIYK(gl)QSQHMTEVVR_
TP53 Ubiquitylation K120 -0.188 _LGFLHSGTAK(gl)SVTCTYSPALNK_
TP53 Ubiquitylation K320 -0.978 _ALPNNTSSSPQPKK(gl)_

Background Information for TP53:


Pubmed-TP53 »
Uniprot-TP53 »
Biogrid-TP53 »
ProteomicsDB-TP53 »

Tumorportal-TP53 »
COSMIC-TP53 »
GenomeRNAi-TP53 »
Genecards-TP53


Protein-protein Interactions for TP53
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AURKA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CELA2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM111A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXW7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR156 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HNF4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HOMER3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MDM4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RORC Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TP53
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members p53_tumour_suppressor IPR002117 0.13
Category members p53_tetrameristn IPR010991 0.13
Category members p53_DNA-bd IPR011615 0.13
Category members p53-like_TF_DNA-bd IPR008967 0


Protein complexes (CORUM database) featuring TP53
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 577 FHL2-p53-HIPK2 complex Database 0.34
Category members Corum 2821 hSIR2-p53 complex Database 0.33
Category members Corum 2179 CNS-P53 complex Database 0.19
Category members Corum 2844 Axin-p53-HIPK2 complex Database 0.13
Category members Corum 98 p300-MDM2-p53 protein complex Database 0.1
Category members Corum 5288 P53-BARD1-Ku70 complex Database 0.06
Category members Corum 2224 MSH2/6-BLM-p53-RAD51 complex Database 0
Category members Corum 2670 Er-alpha-p53-hdm2 complex Database 0
Category members Corum 2678 FOXO3-TP53 complex, oxidative stress stimulated Database 0
Category members Corum 2679 p53-SP1 complex Database 0
Category members Corum 2842 DAXX-Axin-p53-HIPK2 complex Database 0
Category members Corum 3170 Daxx-Axin-p53 complex Database 0
Category members Corum 3172 NUMB-TP53-MDM2 complex Database 0
Category members Corum 5331 YY1-MDM2-p53 complex Database 0


Categories featuring TP53
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0051087 chaperone binding Database 1.69
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_366 BIOCARTA_TEL_PATHWAY 0 1.44
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Database 1.39
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_801 REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 0 1.09
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0005657 replication fork Database 0.95
Category members Pathway Pathway_830 REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE 0 0.93
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Database 0.83
Category members GO Category GO:0009411 response to UV Database 0.79
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members GO Category GO:0051262 protein tetramerization Database 0.6
Category members Pathway Pathway_979 BIOCARTA_ATRBRCA_PATHWAY 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0010332 response to gamma radiation Database 0.52
Category members GO Category GO:0008104 protein localization Database 0.5
Category members GO Category GO:0034644 cellular response to UV Database 0.49
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members Pathway Pathway_980 BIOCARTA_ATM_PATHWAY 0 0.46
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0000060 protein import into nucleus, translocation Database 0.42
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_420 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 0 0.39
Category members Disease phenotype LI-FRAUMENI_SYNDROME_1 LI-FRAUMENI SYNDROME 1 Database 0.37
Category members GO Category GO:0070245 positive regulation of thymocyte apoptotic process Database 0.37
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_744 PID_HDAC_CLASSIII_PATHWAY 0 0.34
Category members Pathway Pathway_985 PID_AURORA_A_PATHWAY 0 0.34
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members GO Category GO:0046902 regulation of mitochondrial membrane permeability Database 0.33
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0010165 response to X-ray Database 0.32
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0.27
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Disease phenotype Precursor_B-cell_acute_lymphoblastic_leukemia Precursor B-cell acute lymphoblastic leukemia Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members Pathway Pathway_891 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION 0 0.24
Category members Pathway Pathway_964 BIOCARTA_CHEMICAL_PATHWAY 0 0.24
Category members Pathway Pathway_982 BIOCARTA_G2_PATHWAY 0 0.24
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_1050 BIOCARTA_RNA_PATHWAY 0 0.21
Category members GO Category GO:0031065 positive regulation of histone deacetylation Database 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members Pathway Pathway_871 BIOCARTA_P53_PATHWAY 0 0.19
Category members GO Category GO:0001836 release of cytochrome c from mitochondria Database 0.18
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members GO Category GO:0070243 regulation of thymocyte apoptotic process Database 0.18
Category members Pathway Pathway_759 BIOCARTA_P53HYPOXIA_PATHWAY 0 0.18
Category members Pathway Pathway_388 KEGG_BLADDER_CANCER 0 0.16
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Disease phenotype Giant_cell_glioblastoma Giant cell glioblastoma Database 0.14
Category members Disease phenotype Gliosarcoma Gliosarcoma Database 0.14
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Disease phenotype LUNG_CANCER LUNG CANCER Database 0.12
Category members Pathway Pathway_347 BIOCARTA_ARF_PATHWAY 0 0.12
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0071158 positive regulation of cell cycle arrest Database 0.11
Category members GO Category GO:0010666 positive regulation of cardiac muscle cell apoptotic process Database 0.11
Category members GO Category GO:0035690 cellular response to drug Database 0.1
Category members GO Category GO:0051097 negative regulation of helicase activity Database 0.1
Category members GO Category GO:0051276 chromosome organization Database 0.1
Category members GO Category GO:0035033 histone deacetylase regulator activity Database 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0046677 response to antibiotic Database 0.08
Category members Pathway Pathway_113 REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 0 0.08
Category members GO Category GO:0031571 mitotic G1 DNA damage checkpoint Database 0.08
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members Disease phenotype Familial_pancreatic_carcinoma Familial pancreatic carcinoma Database 0.06
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members Pathway Pathway_1062 BIOCARTA_PML_PATHWAY 0 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members Disease phenotype ESOPHAGEAL_CANCER ESOPHAGEAL CANCER Database 0.05
Category members GO Category GO:0008340 determination of adult lifespan Database 0.05
Category members GO Category GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding Database 0.05
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members GO Category GO:0034613 cellular protein localization Database 0.04
Category members GO Category GO:0009651 response to salt stress Database 0.04
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Disease phenotype Li-Fraumeni_syndrome Li-Fraumeni syndrome Database 0.04
Category members GO Category GO:0031497 chromatin assembly Database 0.04
Category members GO Category GO:0016604 nuclear body Database 0.04
Category members GO Category GO:0030330 DNA damage response, signal transduction by p53 class mediator Database 0.04
Category members GO Category GO:0002326 B cell lineage commitment Database 0.04
Category members GO Category GO:0002931 response to ischemia Database 0.04
Category members GO Category GO:0035264 multicellular organism growth Database 0.04
Category members GO Category GO:0033077 T cell differentiation in thymus Database 0.03
Category members GO Category GO:0007569 cell aging Database 0.03
Category members GO Category GO:0008156 negative regulation of DNA replication Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members Disease phenotype B-cell_chronic_lymphocytic_leukemia B-cell chronic lymphocytic leukemia Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_1030 BIOCARTA_RB_PATHWAY 0 0
Category members Pathway Pathway_1163 KEGG_BASAL_CELL_CARCINOMA 0 0
Category members Pathway Pathway_1164 SA_G1_AND_S_PHASES 0 0
Category members Pathway Pathway_21 ST_JNK_MAPK_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_422 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_637 BIOCARTA_CTCF_PATHWAY 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_882 BIOCARTA_TID_PATHWAY 0 0
Category members Pathway Pathway_944 KEGG_THYROID_CANCER 0 0
Category members Pathway Pathway_976 PID_HIF1A_PATHWAY 0 0
Category members Pathway Pathway_988 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS 0 0
Category members Pathway Pathway_990 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS 0 0
Category members Disease phenotype Essential_thrombocythemia Essential thrombocythemia Database 0
Category members Disease phenotype SQUAMOUS_CELL_CARCINOMA_HEAD_AND_NECK SQUAMOUS CELL CARCINOMA HEAD AND NECK Database 0
Category members GO Category GO:0000733 DNA strand renaturation Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001085 RNA polymerase II transcription factor binding Database 0
Category members GO Category GO:0001756 somitogenesis Database 0
Category members GO Category GO:0002020 protease binding Database 0
Category members GO Category GO:0002309 T cell proliferation involved in immune response Database 0
Category members GO Category GO:0002360 T cell lineage commitment Database 0
Category members GO Category GO:0005507 copper ion binding Database 0
Category members GO Category GO:0005669 transcription factor TFIID complex Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0006983 ER overload response Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0007369 gastrulation Database 0
Category members GO Category GO:0007406 negative regulation of neuroblast proliferation Database 0
Category members GO Category GO:0007417 central nervous system development Database 0
Category members GO Category GO:0009303 rRNA transcription Database 0
Category members GO Category GO:0009792 embryo development ending in birth or egg hatching Database 0
Category members GO Category GO:0030971 receptor tyrosine kinase binding Database 0
Category members GO Category GO:0032461 positive regulation of protein oligomerization Database 0
Category members GO Category GO:0034103 regulation of tissue remodeling Database 0
Category members GO Category GO:0035035 histone acetyltransferase binding Database 0
Category members GO Category GO:0042149 cellular response to glucose starvation Database 0
Category members GO Category GO:0043523 regulation of neuron apoptotic process Database 0
Category members GO Category GO:0043525 positive regulation of neuron apoptotic process Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048147 negative regulation of fibroblast proliferation Database 0
Category members GO Category GO:0048568 embryonic organ development Database 0
Category members GO Category GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0051721 protein phosphatase 2A binding Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0
Category members Human mutations pubmedid:22842228 Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. (Krauthammer et al, Nat. Genet. 2012 Research article 0


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