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Query: MDM2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MDM2 0 2.607 -0.210 0.080

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MDM2 Phosphorylation S166 0.576 1.068 _AIS(ph)ETEENSDELSGER_
MDM2 Ubiquitylation K363 0.883 _LENSTQAEEGFDVPDCK(gl)K_
MDM2 Ubiquitylation K364 0.883 _LENSTQAEEGFDVPDCK(gl)K_
MDM2 Ubiquitylation K473 0.806 _NK(gl)PCPVCR_
MDM2 Ubiquitylation K334 -0.872 _ENWLPEDK(gl)GK_
MDM2 Ubiquitylation K336 -0.872 _ENWLPEDK(gl)GK_

Background Information for MDM2:


Pubmed-MDM2 »
Uniprot-MDM2 »
Biogrid-MDM2 »
ProteomicsDB-MDM2 »

Tumorportal-MDM2 »
COSMIC-MDM2 »
GenomeRNAi-MDM2 »
Genecards-MDM2


Protein-protein Interactions for MDM2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARNTL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C3orf26 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BJ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAK16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MDM4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDGFB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPAN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPARD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL10A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL37A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPS11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIRT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SURF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TP53 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSPYL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XAGE1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YAF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF274 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF550 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF764 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MDM2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SWIB_MDM2_domain IPR003121 0.6
Category members Znf_RanBP2 IPR001876 0.18
Category members Znf_RING IPR001841 0
Category members p53_neg-reg_MDM_2/4 IPR016495 0


Protein complexes (CORUM database) featuring MDM2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 98 p300-MDM2-p53 protein complex Database 0.1
Category members Corum 2670 Er-alpha-p53-hdm2 complex Database 0
Category members Corum 3172 NUMB-TP53-MDM2 complex Database 0
Category members Corum 5331 YY1-MDM2-p53 complex Database 0


Categories featuring MDM2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members GO Category GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Database 1.39
Category members Pathway Pathway_1254 PID_RANBP2_PATHWAY 0 1.33
Category members Pathway Pathway_549 REACTOME_GAB1_SIGNALOSOME 0 1.25
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_830 REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE 0 0.93
Category members GO Category GO:0042176 regulation of protein catabolic process Database 0.91
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_708 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING 0 0.61
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_991 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members Pathway Pathway_208 PID_TAP63_PATHWAY 0 0.52
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members Pathway Pathway_980 BIOCARTA_ATM_PATHWAY 0 0.46
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members GO Category GO:0030163 protein catabolic process Database 0.38
Category members Pathway Pathway_590 REACTOME_PI_3K_CASCADE 0 0.37
Category members Pathway Pathway_607 REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 0 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_985 PID_AURORA_A_PATHWAY 0 0.34
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members Pathway Pathway_604 REACTOME_PI3K_AKT_ACTIVATION 0 0.32
Category members Pathway Pathway_614 REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 0 0.32
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process Database 0.27
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_982 BIOCARTA_G2_PATHWAY 0 0.24
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process Database 0.24
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members Pathway Pathway_871 BIOCARTA_P53_PATHWAY 0 0.19
Category members Pathway Pathway_1011 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 0 0.18
Category members Pathway Pathway_759 BIOCARTA_P53HYPOXIA_PATHWAY 0 0.18
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members Pathway Pathway_388 KEGG_BLADDER_CANCER 0 0.16
Category members GO Category GO:0032026 response to magnesium ion Database 0.15
Category members GO Category GO:0034504 protein localization to nucleus Database 0.15
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0071391 cellular response to estrogen stimulus Database 0.12
Category members Pathway Pathway_347 BIOCARTA_ARF_PATHWAY 0 0.12
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0048545 response to steroid hormone Database 0.11
Category members GO Category GO:0045184 establishment of protein localization Database 0.1
Category members GO Category GO:0046677 response to antibiotic Database 0.08
Category members GO Category GO:0030666 endocytic vesicle membrane Database 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0045202 synapse Database 0.06
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0042975 peroxisome proliferator activated receptor binding Database 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0045787 positive regulation of cell cycle Database 0.04
Category members GO Category GO:0045931 positive regulation of mitotic cell cycle Database 0.04
Category members Disease phenotype Li-Fraumeni_syndrome Li-Fraumeni syndrome Database 0.04
Category members GO Category GO:0071229 cellular response to acid Database 0.04
Category members GO Category GO:0007089 traversing start control point of mitotic cell cycle Database 0.04
Category members GO Category GO:0016604 nuclear body Database 0.04
Category members GO Category GO:0046827 positive regulation of protein export from nucleus Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0071312 cellular response to alkaloid Database 0.01
Category members GO Category GO:0070301 cellular response to hydrogen peroxide Database 0
Category members Pathway Pathway_1164 SA_G1_AND_S_PHASES 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_209 PID_DELTA_NP63_PATHWAY 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_609 PID_ERBB4_PATHWAY 0 0
Category members Pathway Pathway_637 BIOCARTA_CTCF_PATHWAY 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Disease phenotype Dedifferentiated_liposarcoma Dedifferentiated liposarcoma Database 0
Category members Disease phenotype Well-differentiated_liposarcoma Well-differentiated liposarcoma Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009636 response to toxic substance Database 0
Category members GO Category GO:0009743 response to carbohydrate Database 0
Category members GO Category GO:0010039 response to iron ion Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0010955 negative regulation of protein processing Database 0
Category members GO Category GO:0018205 peptidyl-lysine modification Database 0
Category members GO Category GO:0031648 protein destabilization Database 0
Category members GO Category GO:0042220 response to cocaine Database 0
Category members GO Category GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0043278 response to morphine Database 0
Category members GO Category GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator Database 0
Category members GO Category GO:0045472 response to ether Database 0
Category members GO Category GO:0071157 negative regulation of cell cycle arrest Database 0
Category members GO Category GO:0071236 cellular response to antibiotic Database 0
Category members GO Category GO:0071310 cellular response to organic substance Database 0
Category members GO Category GO:0071363 cellular response to growth factor stimulus Database 0
Category members GO Category GO:0071375 cellular response to peptide hormone stimulus Database 0
Category members GO Category GO:0071407 cellular response to organic cyclic compound Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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