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PID_ERBB4_PATHWAY
(Pathway_609)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
FYN 1 1.080 -1.100
FYN 1 1.080 -1.100
ITCH 1 1.000 -0.610 -0.346 0.023 0.613
PIK3R2 1 2.740 -1.180 0.269 0.348
WWP1 1 -1.400 1.340
WWP1 1 0.850 -1.030
WWP1 1 -1.400 1.340 -0.346 0.023 0.613
WWP1 1 0.850 -1.030 -0.346 0.023 0.613
DLG4 1 -0.020 0.320 1.552 0.102 0.488
WWOX 1 2.850 -1.200
PIK3CB 0 -1.390 2.350
PIK3CB 0 -0.710 1.450
TAB2 0 -0.030 -0.580
NEDD4 0 -1.320 1.730
MAPK3 0
PIK3R3 0 -0.140 -0.480
PIK3R3 0 -0.140 -0.480 -0.441 0.147
PIK3CA 0
CBFA2T3 0 -0.750 1.120
MDM2 0 -0.210 0.080
YAP1 0 1.010 -0.370
NCOR1 0 -0.820 1.130 -0.827 -0.215 0.037
ERBB2 0 -1.310 1.360
LRIG1 0 -1.220 1.350
PIK3R1 0 1.910 -1.220 -0.441 0.147
ADAM17 0 0.520 -0.620
STAT5B 0 0.670 -0.960
GRB2 0 -0.240 0.300 -1.021 0.057 0.906
ERBB4 0
ERBB4 0

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ADAM17 Phosphorylation S791 -0.594 0.152 _S(ph)FEDLTDHPVTR_
CBFA2T3 Ubiquitylation K489 0.393 _K(gl)AEEAVNEVK_
DLG4 Phosphorylation S102 -1.455 _SKPSEPIQPVNTWEISSLPSSTVTSETLPSSLS(ph)PSVEK_
DLG4 Phosphorylation T115 -0.707 -1.378 _YQDEDT(ph)PPQEHISPQITNEVIGPELVHVSEK_
DLG4 Phosphorylation S122 -1.073 _YQDEDTPPQEHIS(ph)PQITNEVIGPELVHVSEK_
DLG4 Phosphorylation S158 0.773 _NLSEIENVHGFVSHSHIS(ph)PIK_
DLG4 Ubiquitylation K321 1.264 1.435 _IMEIK(gl)LIK_
DLG4 Ubiquitylation K361 0.180 _IIEGGAAHK(gl)DGK_
DLG4 Ubiquitylation K452 -0.704 _YSPVSK(gl)AVLGDDEITREPR_
DLG4 Ubiquitylation K556 0.105 _FEAK(gl)IHDLR_
DLG4 Phosphorylation S573 0.697 _EQM(ox)M(ox)NSSISSGS(ph)GSLR_
DLG4 Phosphorylation S575 0.255 0.729 _EQMMNSSISSGSGS(ph)LR_
DLG4 Ubiquitylation K843 1.259 _SMENIMEMNK(gl)R_
ERBB2 Ubiquitylation K200 -2.073 _ACHPCSPMCK(gl)GSR_
ERBB2 Ubiquitylation K369 -0.742 _AVTSANIQEFAGCKK(gl)_
ERBB2 Ubiquitylation K747 -0.505 -0.019 _GIWIPDGENVK(gl)IPVAIK_
ERBB2 Ubiquitylation K854 -0.859 _NVLVK(gl)SPNHVK_
ERBB2 Phosphorylation S1054 -0.476 -0.706 _S(ph)GGGDLTLGLEPSEEEAPR_
ERBB4 Ubiquitylation K714 0.078 _ILK(gl)ETELKR_
ERBB4 Ubiquitylation K745 -0.474 0.342 _GIWVPEGETVK(gl)IPVAIK_
ERBB4 Ubiquitylation K854 -0.859 _NVLVK(gl)SPNHVK_
FYN Ubiquitylation K13 0.286 _DKEATK(gl)LTEER_
FYN Phosphorylation S21 0.373 0.731 _DGS(ph)LNQSSGYR_
FYN Ubiquitylation K259 0.921 _LTDLSVK(gl)TK_
FYN Ubiquitylation K261 0.099 _LTDLSVKTK(gl)_
FYN Ubiquitylation K273 6.025 _SLCLEKK(gl)_
FYN Ubiquitylation K275 -0.521 _ESLQLIK(gl)R_
GRB2 Ubiquitylation K10 0.146 _YDFK(gl)ATADDELSFK_
GRB2 Ubiquitylation K20 -0.078 _ATADDELSFK(gl)R_
GRB2 Ubiquitylation K69 -0.362 0.641 _AK(gl)AEEMLSK_
GRB2 Ubiquitylation K76 0.754 _AEEMLSK(gl)QR_
GRB2 Ubiquitylation K109 0.381 -0.002 _FGNDVQHFK(gl)VLR_
ITCH Ubiquitylation K66 -0.890 _WK(gl)QPLTVIVTPVSK_
ITCH Ubiquitylation K350 0.049 0.396 _VYYVDHVEK(gl)R_
ITCH Ubiquitylation K446 -1.514 -1.539 _EFDPLGPLPPGWEK(gl)R_
ITCH Ubiquitylation K478 -1.265 _SQGQLNEK(gl)PLPEGWEMR_
ITCH Ubiquitylation K513 -0.564 1.593 _TGK(gl)SALDNGPQIAYVR_
ITCH Ubiquitylation K861 -0.810 0.596 _VGK(gl)ENWLPR_
LRIG1 Phosphorylation S1069 -0.682 _ACDAS(ph)PESTPLTGQLPGK_
MAPK3 Phosphorylation Y204 -0.807 -2.487 _IADPEHDHTGFLTEY(ph)VATR_
MAPK3 Ubiquitylation K289 -0.608 _NYLQSLPSKTK(gl)_
MDM2 Phosphorylation S166 0.576 1.068 _AIS(ph)ETEENSDELSGER_
MDM2 Ubiquitylation K334 -0.872 _ENWLPEDK(gl)GK_
MDM2 Ubiquitylation K336 -0.872 _ENWLPEDK(gl)GK_
MDM2 Ubiquitylation K363 0.883 _LENSTQAEEGFDVPDCK(gl)K_
MDM2 Ubiquitylation K364 0.883 _LENSTQAEEGFDVPDCK(gl)K_
MDM2 Ubiquitylation K473 0.806 _NK(gl)PCPVCR_
NCOR1 Phosphorylation S1195 -0.029 0.716 _MPIEDS(ph)SPEKGREEAASK_
NCOR1 Phosphorylation S1196 0.087 0.141 _MPIEDSS(ph)PEKGR_
NCOR1 Phosphorylation S1472 0.700 0.536 _AQLS(ph)PGIYDDTSAR_
NCOR1 Phosphorylation S1977 -0.959 -0.974 _YETPSDAIEVIS(ph)PASSPAPPQEK_
NCOR1 Ubiquitylation K1998 -2.086 _LQTYQPEVVK(gl)ANQAENDPTR_
NCOR1 Phosphorylation S2120 0.148 0.154 _VS(ph)PENLVDK_
NCOR1 Phosphorylation S2151 -1.006 -0.922 _SHVSSEPYEPIS(ph)PPQVPVVHEK_
NCOR1 Phosphorylation S2184 0.120 0.226 _S(ph)PGSISYLPSFFTK_
NCOR1 Phosphorylation S2187 0.396 _SPGS(ph)ISYLPSFFTK_
NEDD4 Phosphorylation Y751 -0.924 _RGSLQAY(ph)TFEEQPTLPVLLPTSSGLPPGWEEK_
NEDD4 Ubiquitylation K874 0.127 _LK(gl)IPAHLR_
NEDD4 Ubiquitylation K882 -0.919 0.114 _GK(gl)TSLDTSNDLGPLPPGWEER_
PIK3CA Ubiquitylation K864 0.390 0.588 _NSHTIM(ox)QIQCK(gl)GGLK_
PIK3CA Ubiquitylation K868 0.204 0.651 _NSHTIM(ox)QIQCKGGLK(gl)_
PIK3CA Ubiquitylation K974 -0.273 _GAQECTK(gl)TREFER_
PIK3CB Ubiquitylation K1044 0.990 _SEEEALKQFKQK(gl)_
PIK3R2 Phosphorylation S262 -2.237 _APPPPS(ph)SPPPGGAPDGSEPSPDFPALLVEK_
PIK3R2 Phosphorylation S263 -2.237 _APPPPS(ph)SPPPGGAPDGSEPSPDFPALLVEK_
PIK3R2 Ubiquitylation K500 -0.189 _IFEEQGQTQEK(gl)CSK_
PIK3R2 Ubiquitylation K541 -0.609 _TK(gl)LEQQLR_
PIK3R2 Ubiquitylation K564 -0.431 -1.022 _MNSLK(gl)PDLMQLR_
PIK3R3 Ubiquitylation K226 -0.376 _YQQDQLVKEDNIDAVGKK(gl)_
PIK3R3 Ubiquitylation K320 0.385 _LGEIHDSK(gl)MR_
STAT5B Phosphorylation S194 0.270 _IQAQFGPLAQLS(ph)PQER_
TAB2 Phosphorylation S580 -0.075 _S(ph)NSISQIPSLEEMQQLR_
TAB2 Phosphorylation S582 0.331 _SNS(ph)ISQIPSLEEMQQLR_
TAB2 Ubiquitylation K653 -0.519 -0.200 _SIIK(gl)TPK_
WWOX Ubiquitylation K100 -1.048 -0.703 _LAFTVDDNPTK(gl)PTTR_
WWP1 Ubiquitylation K66 -0.890 _WK(gl)QPLTVIVTPVSK_
WWP1 Ubiquitylation K328 -0.364 0.487 _SSSAFEAAK(gl)SR_
WWP1 Ubiquitylation K350 0.049 0.396 _VYYVDHVEK(gl)R_
WWP1 Ubiquitylation K446 -1.514 -1.539 _EFDPLGPLPPGWEK(gl)R_
WWP1 Ubiquitylation K478 -1.265 _SQGQLNEK(gl)PLPEGWEMR_
WWP1 Ubiquitylation K513 -0.564 1.593 _TGK(gl)SALDNGPQIAYVR_
WWP1 Ubiquitylation K536 -1.895 1.126 _SSVTK(gl)GGPQIAYER_
WWP1 Ubiquitylation K861 -0.810 0.596 _VGK(gl)ENWLPR_
YAP1 Phosphorylation S61 -0.064 0.017 _GDS(ph)ETDLEALFNAVMNPK_
YAP1 Phosphorylation T63 -0.159 -0.257 _GDSET(ph)DLEALFNAVM(ox)NPK_
YAP1 Phosphorylation T110 0.467 _QAST(ph)DAGTAGALTPQHVR_
YAP1 Phosphorylation S127 -1.544 _AHS(ph)SPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLR_
YAP1 Phosphorylation S131 -1.256 -1.096 _AHSSPAS(ph)LQLGAVSPGTLTPTGVVSGPAATPTAQHLR_
YAP1 Ubiquitylation K315 -0.002 _LQQLQMEK(gl)ER_
YAP1 Ubiquitylation K321 -1.043 _LK(gl)QQELLR_
YAP1 Ubiquitylation K342 -0.589 _NINPSTANSPK(gl)CQELALR_
YAP1 Phosphorylation S367 0.272 _SQLPTLEQDGGTQNPVSS(ph)PGMSQELR_
YAP1 Phosphorylation S397 -0.200 _DES(ph)TDSGLSM(ox)SSYSVPR_


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