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Query: ADAM17

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ADAM17 0 -0.442 0.520 -0.620

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ADAM17 Phosphorylation S791 -0.594 0.152 _S(ph)FEDLTDHPVTR_

Background Information for ADAM17:


Pubmed-ADAM17 »
Uniprot-ADAM17 »
Biogrid-ADAM17 »
ProteomicsDB-ADAM17 »

Tumorportal-ADAM17 »
COSMIC-ADAM17 »
GenomeRNAi-ADAM17 »
Genecards-ADAM17


Protein-protein Interactions for ADAM17
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SGOL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADAM17 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INSL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LMAN2L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST8SIA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ADAM17
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peptidase_M12B_N IPR002870 0.08
Category members Blood-coag_inhib_Disintegrin IPR001762 0.07
Category members Peptidase_M12B IPR001590 0.04


Protein complexes (CORUM database) featuring ADAM17
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ADAM17
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0051272 positive regulation of cellular component movement Database 0.46
Category members GO Category GO:0032496 response to lipopolysaccharide Database 0.35
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0030165 PDZ domain binding Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members Pathway Pathway_1173 BIOCARTA_PS1_PATHWAY 0 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0051088 PMA-inducible membrane protein ectodomain proteolysis Database 0.26
Category members Pathway Pathway_188 KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0 0.24
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0030574 collagen catabolic process Database 0.2
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0005112 Notch binding Database 0.14
Category members GO Category GO:0006509 membrane protein ectodomain proteolysis Database 0.14
Category members GO Category GO:0022617 extracellular matrix disassembly Database 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members GO Category GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway Database 0.06
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0002446 neutrophil mediated immunity Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway Database 0.04
Category members Pathway Pathway_1159 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR 0 0.04
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members GO Category GO:0032717 negative regulation of interleukin-8 production Database 0.04
Category members GO Category GO:0045741 positive regulation of epidermal growth factor-activated receptor activity Database 0.03
Category members Pathway Pathway_815 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR 0 0.03
Category members GO Category GO:0033077 T cell differentiation in thymus Database 0.03
Category members Pathway Pathway_1134 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_609 PID_ERBB4_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Pathway Pathway_831 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 0 0
Category members Pathway Pathway_892 KEGG_NOTCH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_977 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 0 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0002467 germinal center formation Database 0
Category members GO Category GO:0002690 positive regulation of leukocyte chemotaxis Database 0
Category members GO Category GO:0004222 metalloendopeptidase activity Database 0
Category members GO Category GO:0005138 interleukin-6 receptor binding Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007220 Notch receptor processing Database 0
Category members GO Category GO:0008237 metallopeptidase activity Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010820 positive regulation of T cell chemotaxis Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0017124 SH3 domain binding Database 0
Category members GO Category GO:0030183 B cell differentiation Database 0
Category members GO Category GO:0030307 positive regulation of cell growth Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0031293 membrane protein intracellular domain proteolysis Database 0
Category members GO Category GO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Database 0
Category members GO Category GO:0032722 positive regulation of chemokine production Database 0
Category members GO Category GO:0033627 cell adhesion mediated by integrin Database 0
Category members GO Category GO:0035313 wound healing, spreading of epidermal cells Database 0
Category members GO Category GO:0048536 spleen development Database 0
Category members GO Category GO:0048870 cell motility Database 0
Category members GO Category GO:0055099 response to high density lipoprotein particle Database 0


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