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Query: ITCH

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ITCH 1 1.932 1.000 -0.610 -0.346 0.023 0.613

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ITCH Ubiquitylation K513 -0.564 1.593 _TGK(gl)SALDNGPQIAYVR_
ITCH Ubiquitylation K861 -0.810 0.596 _VGK(gl)ENWLPR_
ITCH Ubiquitylation K350 0.049 0.396 _VYYVDHVEK(gl)R_
ITCH Ubiquitylation K446 -1.514 -1.539 _EFDPLGPLPPGWEK(gl)R_
ITCH Ubiquitylation K66 -0.890 _WK(gl)QPLTVIVTPVSK_
ITCH Ubiquitylation K478 -1.265 _SQGQLNEK(gl)PLPEGWEMR_

Background Information for ITCH:


Pubmed-ITCH »
Uniprot-ITCH »
Biogrid-ITCH »
ProteomicsDB-ITCH »

Tumorportal-ITCH »
COSMIC-ITCH »
GenomeRNAi-ITCH »
Genecards-ITCH


Protein-protein Interactions for ITCH
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARRDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARRDC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C18orf1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPSF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM189A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM189B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM70A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ILDR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPG20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM171 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM51 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM66 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM92 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ITCH
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WW_dom IPR001202 1.15
Category members HECT IPR000569 0.04
Category members C2_dom IPR000008 0


Protein complexes (CORUM database) featuring ITCH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1769 CPSF6-ITCH-NUDT21-POLR2A complex Database 0.85
Category members Corum 1767 CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex Database 0.43
Category members Corum 1768 CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex Database 0.23
Category members Corum 783 ITCH-FAM/USP9x complex Database 0


Categories featuring ITCH
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_208 PID_TAP63_PATHWAY 0 0.52
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process Database 0.27
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway Database 0.09
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0046718 viral entry into host cell Database 0.04
Category members GO Category GO:0032088 negative regulation of NF-kappaB transcription factor activity Database 0.04
Category members GO Category GO:0050687 negative regulation of defense response to virus Database 0.03
Category members Pathway Pathway_209 PID_DELTA_NP63_PATHWAY 0 0
Category members Pathway Pathway_489 PID_NFAT_TFPATHWAY 0 0
Category members Pathway Pathway_609 PID_ERBB4_PATHWAY 0 0
Category members GO Category GO:0001558 regulation of cell growth Database 0
Category members GO Category GO:0002669 positive regulation of T cell anergy Database 0
Category members GO Category GO:0016874 ligase activity Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0032480 negative regulation of type I interferon production Database 0
Category members GO Category GO:0035519 protein K29-linked ubiquitination Database 0
Category members GO Category GO:0043021 ribonucleoprotein complex binding Database 0
Category members GO Category GO:0045236 CXCR chemokine receptor binding Database 0
Category members GO Category GO:0045732 positive regulation of protein catabolic process Database 0
Category members GO Category GO:0046329 negative regulation of JNK cascade Database 0
Category members GO Category GO:0046642 negative regulation of alpha-beta T cell proliferation Database 0
Category members GO Category GO:0070534 protein K63-linked ubiquitination Database 0
Category members GO Category GO:0070936 protein K48-linked ubiquitination Database 0


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