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Query: FYN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FYN 1 8.050 1.080 -1.100

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FYN Ubiquitylation K259 0.921 _LTDLSVK(gl)TK_
FYN Phosphorylation S21 0.373 0.731 _DGS(ph)LNQSSGYR_
FYN Ubiquitylation K273 6.025 _SLCLEKK(gl)_
FYN Ubiquitylation K13 0.286 _DKEATK(gl)LTEER_
FYN Ubiquitylation K261 0.099 _LTDLSVKTK(gl)_
FYN Ubiquitylation K275 -0.521 _ESLQLIK(gl)R_

Background Information for FYN:


Pubmed-FYN »
Uniprot-FYN »
Biogrid-FYN »
ProteomicsDB-FYN »

Tumorportal-FYN »
COSMIC-FYN »
GenomeRNAi-FYN »
Genecards-FYN


Protein-protein Interactions for FYN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait OSGEP Cat. description Hein, Mann, Cell 2015
Category members IP bait PMS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SOD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM132A Cat. description Hein, Mann, Cell 2015
Category members IP bait TSNAX Cat. description Hein, Mann, Cell 2015
Category members IP bait ZNFX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACBD7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FYN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GJB7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HOXB5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRIQ1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MTUS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHGC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRUNE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC4A8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM185A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FYN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH3_2 IPR011511 0.08
Category members SH2 IPR000980 0.05
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members SH3_domain IPR001452 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring FYN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2351 ITGB6-FYN-FN1 complex Database 0.04
Category members Corum 2563 FGFR2-c-Cbl-Lyn-Fyn complex Database 0.02
Category members Corum 2564 p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated Database 0.02
Category members Corum 2565 CD20-LCK-LYN-FYN-p75/80 complex, (Raji human B cell line) Database 0.02
Category members Corum 2321 ITGA6-ITGB4-FYN complex Database 0
Category members Corum 2879 CD20-LCK-FYN-p75/80 complex Database 0
Category members Corum 5641 PSD95-FYN-NR2A complex Database 0


Categories featuring FYN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members Pathway Pathway_1147 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION 0 1.89
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members Pathway Pathway_611 PID_ECADHERIN_KERATINOCYTE_PATHWAY 0 1.34
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members Pathway Pathway_672 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION 0 0.88
Category members Pathway Pathway_194 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS 0 0.83
Category members GO Category GO:0015631 tubulin binding Database 0.83
Category members Pathway Pathway_936 REACTOME_CTLA4_INHIBITORY_SIGNALING 0 0.77
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0042493 response to drug Database 0.66
Category members Pathway Pathway_1074 PID_SYNDECAN_3_PATHWAY 0 0.65
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0050690 regulation of defense response to virus by virus Database 0.49
Category members Pathway Pathway_563 REACTOME_NEPHRIN_INTERACTIONS 0 0.49
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members Pathway Pathway_1026 KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 0 0.45
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0046875 ephrin receptor binding Database 0.3
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_536 BIOCARTA_ECM_PATHWAY 0 0.25
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0048813 dendrite morphogenesis Database 0.23
Category members Pathway Pathway_957 PID_AMB2_NEUTROPHILS_PATHWAY 0 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_1036 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY 0 0.18
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members Pathway Pathway_555 PID_NEPHRIN_NEPH1_PATHWAY 0 0.17
Category members Pathway Pathway_705 PID_CD8_TCR_PATHWAY 0 0.17
Category members Pathway Pathway_1282 REACTOME_CRMPS_IN_SEMA3A_SIGNALING 0 0.17
Category members Pathway Pathway_1033 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING 0 0.14
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_622 REACTOME_CD28_CO_STIMULATION 0 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_601 PID_IL2_1PATHWAY 0 0.1
Category members GO Category GO:0007166 cell surface receptor signaling pathway Database 0.1
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members Pathway Pathway_1158 BIOCARTA_EPHA4_PATHWAY 0 0.08
Category members Pathway Pathway_687 PID_TCR_PATHWAY 0 0.08
Category members Pathway Pathway_405 PID_ALPHA_SYNUCLEIN_PATHWAY 0 0.08
Category members GO Category GO:0007631 feeding behavior Database 0.07
Category members Pathway Pathway_620 REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 0 0.06
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members Pathway Pathway_600 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 0 0.05
Category members GO Category GO:0010976 positive regulation of neuron projection development Database 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_434 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 0 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members GO Category GO:0070851 growth factor receptor binding Database 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members Pathway Pathway_695 REACTOME_PECAM1_INTERACTIONS 0 0.04
Category members GO Category GO:0042610 CD8 receptor binding Database 0.04
Category members Pathway Pathway_543 BIOCARTA_TCR_PATHWAY 0 0.03
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members Pathway Pathway_1235 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN 0 0.02
Category members Pathway Pathway_642 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE 0 0.02
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_558 PID_REELIN_PATHWAY 0 0.01
Category members Pathway Pathway_665 PID_EPHA_FWDPATHWAY 0 0.01
Category members Pathway Pathway_1010 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 0 0
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1039 PID_P38_ALPHA_BETA_PATHWAY 0 0
Category members Pathway Pathway_1113 REACTOME_REGULATION_OF_KIT_SIGNALING 0 0
Category members Pathway Pathway_1283 BIOCARTA_TCRA_PATHWAY 0 0
Category members Pathway Pathway_430 PID_TXA2PATHWAY 0 0
Category members Pathway Pathway_500 PID_FCER1_PATHWAY 0 0
Category members Pathway Pathway_502 PID_PI3KCI_PATHWAY 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_506 REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 0 0
Category members Pathway Pathway_530 KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_547 PID_EPHRINB_REV_PATHWAY 0 0
Category members Pathway Pathway_551 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING 0 0
Category members Pathway Pathway_576 REACTOME_REGULATION_OF_SIGNALING_BY_CBL 0 0
Category members Pathway Pathway_582 BIOCARTA_IL7_PATHWAY 0 0
Category members Pathway Pathway_602 PID_PTP1B_PATHWAY 0 0
Category members Pathway Pathway_609 PID_ERBB4_PATHWAY 0 0
Category members Pathway Pathway_640 PID_NETRIN_PATHWAY 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_659 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS 0 0
Category members Pathway Pathway_692 REACTOME_NETRIN1_SIGNALING 0 0
Category members Pathway Pathway_704 BIOCARTA_BIOPEPTIDES_PATHWAY 0 0
Category members Pathway Pathway_718 PID_GLYPICAN_1PATHWAY 0 0
Category members Pathway Pathway_883 KEGG_PRION_DISEASES 0 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0001948 glycoprotein binding Database 0
Category members GO Category GO:0004715 non-membrane spanning protein tyrosine kinase activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0006816 calcium ion transport Database 0
Category members GO Category GO:0007612 learning Database 0
Category members GO Category GO:0008360 regulation of cell shape Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0014069 postsynaptic density Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0031295 T cell costimulation Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0042177 negative regulation of protein catabolic process Database 0
Category members GO Category GO:0042608 T cell receptor binding Database 0
Category members GO Category GO:0042609 CD4 receptor binding Database 0
Category members GO Category GO:0043548 phosphatidylinositol 3-kinase binding Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050798 activated T cell proliferation Database 0
Category members GO Category GO:0050966 detection of mechanical stimulus involved in sensory perception of pain Database 0
Category members GO Category GO:0051428 peptide hormone receptor binding Database 0
Category members GO Category GO:0071363 cellular response to growth factor stimulus Database 0
Category members GO Category GO:0071375 cellular response to peptide hormone stimulus Database 0


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