RNAi screen result	RNAPII IP (MG132)	CSB IP	CSB IP (MG132)	Chrom.	Chrom. (MG132)	Ubi /Phospo	Ubi /Phospho (MG132)
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Gene name	MGoogle Score	RNAi high	RNAi low	RNAPII-IP (MG132)	CSB-IP	CSB-IP (MG132)	Chrom.	Chrom. (MG132)
JUN	3	-0.930	0.930			-0.126
MAPK14	2	-0.160	-0.350
FYN	1	1.080	-1.100
FYN	1	1.080	-1.100
MAPK9	1	0.110	-0.490
PPP2R5D	1	-0.110	0.620
PPP2R5D	1	-0.110	0.620				-0.455	-0.019
RAF1	1	2.020	-1.230
KRAS	1	-0.510	0.620				1.031	0.887
KRAS	1	-0.510	0.620				0.246	-0.346
MAP2K1	1	-1.590	2.780
NRAS	1	1.810	-0.720				0.246	-0.346
RHOA	0	-0.510	1.370	-0.485			0.532	0.279
MAPK3	0
STAM2	0	-0.510	0.650
STAT1	0	-0.550	0.170
SOS1	0	0.500	-0.620	-0.570
PIK3CA	0
CDK2	0	-0.040	-0.300				-0.578	-0.797
CDK2	0	-0.040	-0.300	-0.202	-0.884	-0.107	-0.097	-0.501
MAP2K2	0	-0.610	0.080
MAP2K2	0	-0.610	0.080
MYC	0	0.170	0.550	-2.443	-0.949	-0.454		-1.290
PIK3R1	0	1.910	-1.220				-0.441	0.147
IKZF3	0	0.290	-0.100
JAK1	0	0.190	-0.100		-1.504	-0.381		-0.438
PRKCB	0	0.260	-0.530
PRKCB	0	0.260	-0.530				0.349	0.585
STAT3	0	0.200	-1.270					0.334
IRS1	0
BCL2	0	0.910	-0.740
STAT5B	0	0.670	-0.960
HRAS	0	1.470	-0.520
GRB2	0	-0.240	0.300		-1.021	0.057	0.906
PTPN11	0	-0.210	-0.400	0.644			1.053	0.451
LCK	0	-0.490	1.390				0.295	0.576
IRS2	0	-0.190	-0.130

Gene name	PTM type	PTM site	UV	UV (MG132)	Sequence
BCL2	Ubiquitylation	K22	1.480		_YIHYK(gl)LSQR_
CDK2	Ubiquitylation	K6	-0.130	-0.399	_(ac)MENFQK(gl)VEK_
CDK2	Ubiquitylation	K6	0.011	-0.784	_(ac)M(ox)EDYTK(gl)IEK_
CDK2	Phosphorylation	T14	0.429		_IGEGT(ph)YGVVYK_
CDK2	Phosphorylation	Y15	0.697	0.743	_IGEGTY(ph)GVVYK_
CDK2	Ubiquitylation	K20		0.272	_IGEGTYGVVYK(gl)AR_
CDK2	Ubiquitylation	K20	-0.327	-0.270	_IGEGTYGVVYK(gl)GR_
CDK2	Ubiquitylation	K24	0.366		_NK(gl)LTGEVVALKK_
CDK2	Ubiquitylation	K33		0.033	_NKLTGEVVALK(gl)K_
CDK2	Ubiquitylation	K33	0.736	0.239	_TTGQVVAMK(gl)K_
CDK2	Ubiquitylation	K34		0.542	_LTGEVVALKK(gl)_
CDK2	Ubiquitylation	K34		-0.306	_TTGQVVAMKK(gl)_
CDK2	Ubiquitylation	K58	0.312	-0.262	_EISLLK(gl)ELR_
CDK2	Ubiquitylation	K136		-0.468	_DLK(gl)PQNLLIDDK(gl)GTIK_
CDK2	Ubiquitylation	K145	0.161	-0.954	_DLKPQNLLIDDK(gl)GTIK_
CDK2	Ubiquitylation	K149		-0.038	_GTIK(gl)LADFGLAR_
CDK2	Ubiquitylation	K251	-0.047	-1.236	_WK(gl)PGSLASHVK_
CDK2	Ubiquitylation	K280	0.179	-1.210	_MLIYDPAK(gl)R_
CDK2	Ubiquitylation	K298	-1.907	-2.380	_QDFSK(gl)VVPPLDEDGR_
FYN	Ubiquitylation	K13	0.286		_DKEATK(gl)LTEER_
FYN	Phosphorylation	S21	0.373	0.731	_DGS(ph)LNQSSGYR_
FYN	Ubiquitylation	K259		0.921	_LTDLSVK(gl)TK_
FYN	Ubiquitylation	K261	0.099		_LTDLSVKTK(gl)_
FYN	Ubiquitylation	K273	6.025		_SLCLEKK(gl)_
FYN	Ubiquitylation	K275	-0.521		_ESLQLIK(gl)R_
GRB2	Ubiquitylation	K10	0.146		_YDFK(gl)ATADDELSFK_
GRB2	Ubiquitylation	K20	-0.078		_ATADDELSFK(gl)R_
GRB2	Ubiquitylation	K69	-0.362	0.641	_AK(gl)AEEMLSK_
GRB2	Ubiquitylation	K76	0.754		_AEEMLSK(gl)QR_
GRB2	Ubiquitylation	K109	0.381	-0.002	_FGNDVQHFK(gl)VLR_
HRAS	Ubiquitylation	K170	-1.005		_K(gl)LNPPDESGPGCMSCK_
IKZF3	Phosphorylation	S378		0.119	_GLS(ph)PNNSGHDSTDTDSNHEER_
IRS1	Phosphorylation	S1101	-0.078		_HSS(ph)ETFSSTPSATR_
IRS2	Phosphorylation	S308	-0.079	-0.510	_SKS(ph)QSSGSSATHPISVPGAR_
IRS2	Phosphorylation	T365	0.641	0.852	_T(ph)ASEGDGGAAAGAAAAGAR_
IRS2	Phosphorylation	S367	0.757	0.612	_TAS(ph)EGDGGAAAGAAAAGAR_
IRS2	Phosphorylation	S393	-1.580	-1.221	_PVSVAGSPLS(ph)PGPVR_
IRS2	Phosphorylation	S520	0.359	-1.006	_S(ph)NTPESIAETPPAR_
IRS2	Phosphorylation	T522	-1.103	-0.770	_SNT(ph)PESIAETPPAR_
IRS2	Phosphorylation	T529	0.230	0.164	_S(ph)NTPESIAET(ph)PPAR_
IRS2	Phosphorylation	S562	-0.026	0.439	_RVS(ph)GDAAQDLDR_
IRS2	Phosphorylation	S579	0.542	0.362	_RTYS(ph)LTTPAR_
IRS2	Phosphorylation	S621		-0.190	_LCPSCPAS(ph)SPK_
IRS2	Phosphorylation	S622	-0.195		_LCPSCPASS(ph)PK_
IRS2	Phosphorylation	S681	0.409		_SDDYM(ox)PM(ox)S(ph)PASVSAPK_
IRS2	Phosphorylation	S732	-1.089		_AS(ph)SPAESSPEDSGYM(ox)R_
IRS2	Phosphorylation	S733	-1.027	0.522	_ASS(ph)PAESSPEDSGYM(ox)R_
IRS2	Phosphorylation	S738		0.522	_ASS(ph)PAESS(ph)PEDSGYMR_
IRS2	Phosphorylation	S917	-0.592	-1.025	_S(ph)PGEYINIDFGEPGAR_
IRS2	Phosphorylation	S1164		-0.499	_HSSETFSSTTTVTPVS(ph)PSFAHNPK_
IRS2	Phosphorylation	S1178	0.766	0.277	_HNSAS(ph)VENVSLR_
IRS2	Phosphorylation	T1204		-0.454	_SSEGGVGVGPGGGDEPPT(ph)SPR_
IRS2	Phosphorylation	S1205	-0.291		_SSEGGVGVGPGGGDEPPTS(ph)PR_
JAK1	Ubiquitylation	K227	-0.405		_YIPETLNK(gl)SIR_
JAK1	Ubiquitylation	K249	0.116	0.771	_DFLK(gl)EFNNK_
JAK1	Ubiquitylation	K559	-0.478		_EISNLLVATK(gl)K_
JUN	Phosphorylation	S58	-0.167	-1.247	_AKNS(ph)DLLTSPDVGLLK_
JUN	Phosphorylation	T62	2.545	1.674	_NSDLLT(ph)SPDVGLLK_
JUN	Phosphorylation	S63	2.030	1.458	_NSDLLTS(ph)PDVGLLK_
JUN	Ubiquitylation	K70	9.213		_NSDLLTSPDVGLLK(gl)_
JUN	Phosphorylation	S73	1.499	0.845	_LAS(ph)PELER_
JUN	Phosphorylation	S243	-0.642	-1.399	_LQALKEEPQTVPEMPGETPPLS(ph)PIDMESQER_
JUN	Ubiquitylation	K309	1.034	0.155	_EQVAQLK(gl)QK_
KRAS	Ubiquitylation	K128	1.528	1.433	_TVDTK(gl)QAHELAK_
KRAS	Ubiquitylation	K235	0.591	0.087	_TVDTK(gl)QAQDLAR_
KRAS	Ubiquitylation	K254	-0.450	-0.156	_SYGIPFIETSAK(gl)TR_
LCK	Phosphorylation	T37		-0.435	_YRPENTPEPVSTSVSHYGAEPT(ph)TVSPCPSSSAK_
LCK	Ubiquitylation	K191	-0.112	0.264	_ESETTK(gl)GAYSLSIR_
LCK	Ubiquitylation	K235	0.323		_AQFDTLQK(gl)LVK_
LCK	Ubiquitylation	K259		-1.613	_LTTVCPTVK(gl)PQTQGLAK_
MAP2K1	Ubiquitylation	K192	-0.205	-0.241	_DVK(gl)PSNILVNSR_
MAP2K1	Phosphorylation	S385		0.066	_RSDAEEVDFAGWLCSTIGLNQPS(ph)TPTHAAGV_
MAP2K1	Phosphorylation	T386		0.377	_RSDAEEVDFAGWLCSTIGLNQPST(ph)PTHAAGV_
MAP2K2	Phosphorylation	S23	0.873	0.258	_RKPVLPALTINPTIAEGPS(ph)PTSEGASEANLVDLQK_
MAP2K2	Phosphorylation	T25		0.439	_RKPVLPALTINPTIAEGPSPT(ph)SEGASEANLVDLQK_
MAP2K2	Ubiquitylation	K192	-0.205	-0.241	_DVK(gl)PSNILVNSR_
MAP2K2	Phosphorylation	S293		-0.361	_ELEAIFGRPVVDGEEGEPHS(ph)ISPR_
MAP2K2	Phosphorylation	S295	-0.234	0.026	_ELEAIFGRPVVDGEEGEPHSIS(ph)PR_
MAP2K2	Phosphorylation	T394	0.570	0.158	_LNQPGT(ph)PTR_
MAPK14	Phosphorylation	S2	3.221	3.623	_(ac)S(ph)QERPTFYR_
MAPK14	Phosphorylation	T180	0.958	1.087	_HTDDEM(ox)T(ph)GYVATR_
MAPK14	Phosphorylation	Y182	1.388	1.374	_HTDDEM(ox)TGY(ph)VATR_
MAPK14	Ubiquitylation	K249	0.073	-1.380	_LVGTPGAELLKK(gl)_
MAPK3	Phosphorylation	Y204	-0.807	-2.487	_IADPEHDHTGFLTEY(ph)VATR_
MAPK3	Ubiquitylation	K289		-0.608	_NYLQSLPSKTK(gl)_
MAPK9	Phosphorylation	Y185		3.533	_TACTNFMMTPY(ph)VVTR_
MYC	Phosphorylation	S20	-1.444	-1.145	_PLNVS(ph)FTNR_
MYC	Phosphorylation	T72	-1.699	-1.813	_FELLPT(ph)PPLS(ph)PSRR_
MYC	Phosphorylation	S76	-1.777	-1.435	_FELLPTPPLS(ph)PSR_
MYC	Phosphorylation	S81		0.459	_S(ph)GLCSPSYVAVTPFSLR_
MYC	Phosphorylation	S85	0.199	0.073	_SGLCS(ph)PSYVAVTPFSLR_
MYC	Ubiquitylation	K162	-2.475	-1.259	_LVSEK(gl)LASYQAAR_
MYC	Phosphorylation	S295		-0.903	_SESGS(ph)PSAGGHSKPPHSPLVLK_
MYC	Phosphorylation	S307		-1.486	_SES(ph)GSPSAGGHSKPPHS(ph)PLVLK_
MYC	Ubiquitylation	K340		-2.449	_VK(gl)LDSVR_
MYC	Ubiquitylation	K403		-3.432	_DQIPELENNEK(gl)APK_
NRAS	Ubiquitylation	K128	1.528	1.433	_TVDTK(gl)QAHELAK_
PIK3CA	Ubiquitylation	K864	0.390	0.588	_NSHTIM(ox)QIQCK(gl)GGLK_
PIK3CA	Ubiquitylation	K868	0.204	0.651	_NSHTIM(ox)QIQCKGGLK(gl)_
PIK3CA	Ubiquitylation	K974	-0.273		_GAQECTK(gl)TREFER_
PPP2R5D	Phosphorylation	T63		-1.449	_RPSNST(ph)PPPTQLSK_
PPP2R5D	Ubiquitylation	K232	-0.302		_FLESPDFQPNIAK(gl)K_
PPP2R5D	Ubiquitylation	K233	-0.302	0.665	_FLESPDFQPNIAKK(gl)_
PPP2R5D	Ubiquitylation	K409		-0.010	_QLAK(gl)CVSSPHFQVAER_
PPP2R5D	Phosphorylation	S573	0.524	0.357	_RKS(ph)ELPQDVYTIK_
PPP2R5D	Phosphorylation	S598	-0.317	1.858	_RAEEFLTAS(ph)QEAL_
PRKCB	Phosphorylation	S10	-0.650	0.036	_(ac)ADVFPGNDS(ph)TASQDVANR_
PRKCB	Phosphorylation	S13	-1.038	0.335	_(ac)ADVFPGNDSTAS(ph)QDVANR_
PRKCB	Phosphorylation	S226	0.693	0.415	_STLNPQWNES(ph)FTFK_
PRKCB	Ubiquitylation	K315	0.213	0.518	_ISQGTK(gl)VPEEK_
PTPN11	Ubiquitylation	K124	0.562		_EAEK(gl)LLTEK_
RAF1	Phosphorylation	S29	0.028	-0.571	_DAVFDGSSCIS(ph)PTIVQQFGYQR_
RAF1	Phosphorylation	T31	0.028	-0.669	_DAVFDGSSCIS(ph)PTIVQQFGYQR_
RAF1	Phosphorylation	S244		0.053	_YSTPHAFTFNTSS(ph)PSSEGSLSQR_
RAF1	Phosphorylation	S259	-0.069	0.054	_STS(ph)TPNVHM(ox)VSTTLPVDSR_
RAF1	Phosphorylation	S301		-0.651	_SHSESASPSALSSSPNNLS(ph)PTGWSQPK_
RAF1	Phosphorylation	T303		-0.664	_SHSESASPSALSSSPNNLSPT(ph)GWSQPK_
RAF1	Phosphorylation	S497		-0.449	_SRWS(ph)GSQQVEQPTGSVLWMAPEVIR_
RAF1	Phosphorylation	S621	0.212	0.271	_SAS(ph)EPSLHR_
RAF1	Phosphorylation	S642	-0.197	0.463	_AAHTEDINACTLTTS(ph)PR_
RHOA	Ubiquitylation	K6	0.708		_K(gl)KLVIVGDGACGK_
RHOA	Ubiquitylation	K7	0.708		_K(gl)KLVIVGDGACGK_
RHOA	Ubiquitylation	K118	-0.408		_HFCPNVPIILVGNK(gl)K_
RHOA	Ubiquitylation	K119	-0.408		_HFCPNVPIILVGNK(gl)K_
RHOA	Ubiquitylation	K135	-0.528	-0.796	_MK(gl)QEPVKPEEGRDMANR_
RHOA	Ubiquitylation	K162	0.345	0.453	_IGAFGYMECSAK(gl)TK_
SOS1	Phosphorylation	S1082	0.278		_IPESETESTASAPNS(ph)PR_
SOS1	Phosphorylation	S1166	0.097	-0.094	_RPESAPAES(ph)SPSK_
STAM2	Ubiquitylation	K182	-0.024	-0.067	_AIELSLQEQK(gl)QQHTETK_
STAM2	Ubiquitylation	K189	-0.345	-0.068	_QQHTETK(gl)SLYPSSEIQLNNK_
STAM2	Ubiquitylation	K202	-0.516	-0.231	_SLYPSSEIQLNNK(gl)VAR_
STAT1	Phosphorylation	S727	1.377	0.974	_LQTTDNLLPMS(ph)PEEFDEVSR_
STAT3	Ubiquitylation	K177	0.957		_VVENLQDDFDFNYK(gl)TLK_
STAT3	Ubiquitylation	K180	1.179		_TLK(gl)SQGDMQDLNGNNQSVTR_
STAT3	Ubiquitylation	K244	0.262		_TLTDEELADWK(gl)R_
STAT3	Phosphorylation	T714		-0.338	_FICVT(ph)PTTCSNTIDLPMS(ph)PR_
STAT3	Phosphorylation	S727	-0.079	0.156	_FICVTPTTCSNTIDLPMS(ph)PR_
STAT5B	Phosphorylation	S194		0.270	_IQAQFGPLAQLS(ph)PQER_