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Query: JUN

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
JUN 3 14.391 -0.930 0.930 -0.126

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
JUN Phosphorylation T62 2.545 1.674 _NSDLLT(ph)SPDVGLLK_
JUN Phosphorylation S63 2.030 1.458 _NSDLLTS(ph)PDVGLLK_
JUN Phosphorylation S73 1.499 0.845 _LAS(ph)PELER_
JUN Ubiquitylation K309 1.034 0.155 _EQVAQLK(gl)QK_
JUN Phosphorylation S58 -0.167 -1.247 _AKNS(ph)DLLTSPDVGLLK_
JUN Phosphorylation S243 -0.642 -1.399 _LQALKEEPQTVPEMPGETPPLS(ph)PIDMESQER_
JUN Ubiquitylation K70 9.213 _NSDLLTSPDVGLLK(gl)_

Background Information for JUN:


Pubmed-JUN »
Uniprot-JUN »
Biogrid-JUN »
ProteomicsDB-JUN »

Tumorportal-JUN »
COSMIC-JUN »
GenomeRNAi-JUN »
Genecards-JUN


Protein-protein Interactions for JUN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FOS Cat. description Hein, Mann, Cell 2015
Category members IP bait FOSL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUN Cat. description Hein, Mann, Cell 2015
Category members IP bait AHCYL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARHGAP22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARIH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BATF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC67 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC97 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNDBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLEC3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CREB5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOSL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait JUNB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MLLT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCKIPSD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RALBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RFWD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPM3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in JUN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Leuzip_Jun IPR002112 0.11
Category members JNK IPR005643 0.11
Category members bZIP IPR004827 0
Category members TF_DNA-bd IPR008917 0


Protein complexes (CORUM database) featuring JUN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2708 SMAD3-SMAD4-cJUN complex Database 0.11
Category members Corum 2699 ER-alpha-GRIP1-c-Jun complex Database 0.07
Category members Corum 1816 JUN-TCF4-CTNNB1 complex Database 0.06
Category members Corum 2692 SMAD3-SMAD4-cJun-cFos complex Database 0
Category members Corum 2693 NFAT-JUN-FOS DNA-protein complex Database 0
Category members Corum 2694 ERG-JUN-FOS DNA-protein complex Database 0
Category members Corum 2695 ETS2-FOS-JUN complex Database 0
Category members Corum 2700 ER-alpha-c-Jun complex Database 0


Categories featuring JUN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members Pathway Pathway_962 BIOCARTA_FAS_PATHWAY 0 1.75
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_237 PID_LYSOPHOSPHOLIPID_PATHWAY 0 1.09
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members Pathway Pathway_669 PID_RAC1_PATHWAY 0 0.68
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_1078 PID_S1P_S1P2_PATHWAY 0 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0001889 liver development Database 0.51
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members Pathway Pathway_980 BIOCARTA_ATM_PATHWAY 0 0.46
Category members GO Category GO:0030224 monocyte differentiation Database 0.45
Category members Pathway Pathway_963 BIOCARTA_TNFR1_PATHWAY 0 0.44
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0032496 response to lipopolysaccharide Database 0.35
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0001102 RNA polymerase II activating transcription factor binding Database 0.31
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members GO Category GO:0043923 positive regulation by host of viral transcription Database 0.27
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_188 KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0 0.24
Category members Pathway Pathway_891 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION 0 0.24
Category members GO Category GO:0048661 positive regulation of smooth muscle cell proliferation Database 0.24
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0009612 response to mechanical stimulus Database 0.23
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members Pathway Pathway_1001 REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 0 0.2
Category members Pathway Pathway_648 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.19
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0042542 response to hydrogen peroxide Database 0.19
Category members Pathway Pathway_534 BIOCARTA_GLEEVEC_PATHWAY 0 0.18
Category members GO Category GO:0001836 release of cytochrome c from mitochondria Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_555 PID_NEPHRIN_NEPH1_PATHWAY 0 0.17
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members Pathway Pathway_686 BIOCARTA_BCR_PATHWAY 0 0.16
Category members GO Category GO:0005719 nuclear euchromatin Database 0.15
Category members Pathway Pathway_1041 BIOCARTA_AGR_PATHWAY 0 0.13
Category members Pathway Pathway_532 PID_ERBB2_ERBB3_PATHWAY 0 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0043922 negative regulation by host of viral transcription Database 0.12
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members Pathway Pathway_601 PID_IL2_1PATHWAY 0 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_997 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS 0 0.09
Category members Pathway Pathway_578 BIOCARTA_EGF_PATHWAY 0 0.09
Category members Pathway Pathway_584 BIOCARTA_TPO_PATHWAY 0 0.08
Category members Pathway Pathway_113 REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 0 0.08
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members GO Category GO:0007184 SMAD protein import into nucleus Database 0.08
Category members GO Category GO:0035497 cAMP response element binding Database 0.08
Category members GO Category GO:0009314 response to radiation Database 0.07
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0048146 positive regulation of fibroblast proliferation Database 0.05
Category members Pathway Pathway_996 REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 0 0.05
Category members GO Category GO:0045657 positive regulation of monocyte differentiation Database 0.05
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members Pathway Pathway_653 BIOCARTA_MET_PATHWAY 0 0.04
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members GO Category GO:0034146 toll-like receptor 5 signaling pathway Database 0.04
Category members GO Category GO:0034166 toll-like receptor 10 signaling pathway Database 0.04
Category members Pathway Pathway_1059 PID_TCR_JNK_PATHWAY 0 0.04
Category members GO Category GO:0034162 toll-like receptor 9 signaling pathway Database 0.04
Category members Pathway Pathway_543 BIOCARTA_TCR_PATHWAY 0 0.03
Category members Pathway Pathway_690 BIOCARTA_CCR5_PATHWAY 0 0.03
Category members Pathway Pathway_630 BIOCARTA_PDGF_PATHWAY 0 0.03
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members GO Category GO:0051090 regulation of sequence-specific DNA binding transcription factor activity Database 0.02
Category members Pathway Pathway_517 ST_GRANULE_CELL_SURVIVAL_PATHWAY 0 0.02
Category members GO Category GO:0043392 negative regulation of DNA binding Database 0.01
Category members GO Category GO:0034134 toll-like receptor 2 signaling pathway Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1021 ST_TUMOR_NECROSIS_FACTOR_PATHWAY 0 0
Category members Pathway Pathway_1046 BIOCARTA_STRESS_PATHWAY 0 0
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1054 BIOCARTA_IL1R_PATHWAY 0 0
Category members Pathway Pathway_1077 BIOCARTA_IL2_PATHWAY 0 0
Category members Pathway Pathway_1079 BIOCARTA_IL6_PATHWAY 0 0
Category members Pathway Pathway_1094 BIOCARTA_ARENRF2_PATHWAY 0 0
Category members Pathway Pathway_1097 BIOCARTA_ETS_PATHWAY 0 0
Category members Pathway Pathway_186 PID_HNF3A_PATHWAY 0 0
Category members Pathway Pathway_21 ST_JNK_MAPK_PATHWAY 0 0
Category members Pathway Pathway_218 BIOCARTA_GPCR_PATHWAY 0 0
Category members Pathway Pathway_234 PID_ENDOTHELIN_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_359 BIOCARTA_DREAM_PATHWAY 0 0
Category members Pathway Pathway_407 BIOCARTA_HIF_PATHWAY 0 0
Category members Pathway Pathway_422 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_424 KEGG_LEISHMANIA_INFECTION 0 0
Category members Pathway Pathway_440 PID_FRA_PATHWAY 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_445 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 0 0
Category members Pathway Pathway_489 PID_NFAT_TFPATHWAY 0 0
Category members Pathway Pathway_500 PID_FCER1_PATHWAY 0 0
Category members Pathway Pathway_531 PID_PDGFRA_PATHWAY 0 0
Category members Pathway Pathway_540 PID_BCR_5PATHWAY 0 0
Category members Pathway Pathway_564 PID_AVB3_OPN_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_577 BIOCARTA_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_597 BIOCARTA_FCER1_PATHWAY 0 0
Category members Pathway Pathway_612 KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_627 BIOCARTA_NGF_PATHWAY 0 0
Category members Pathway Pathway_631 PID_IL1_PATHWAY 0 0
Category members Pathway Pathway_632 BIOCARTA_IGF1_PATHWAY 0 0
Category members Pathway Pathway_643 PID_RET_PATHWAY 0 0
Category members Pathway Pathway_652 PID_IL6_7_PATHWAY 0 0
Category members Pathway Pathway_657 PID_FGF_PATHWAY 0 0
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members Pathway Pathway_682 BIOCARTA_CDMAC_PATHWAY 0 0
Category members Pathway Pathway_691 BIOCARTA_CARDIACEGF_PATHWAY 0 0
Category members Pathway Pathway_693 BIOCARTA_PYK2_PATHWAY 0 0
Category members Pathway Pathway_700 BIOCARTA_EPO_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_725 ST_GA12_PATHWAY 0 0
Category members Pathway Pathway_732 PID_TCR_CALCIUM_PATHWAY 0 0
Category members Pathway Pathway_897 PID_CD8_TCR_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_901 BIOCARTA_IL12_PATHWAY 0 0
Category members Pathway Pathway_902 BIOCARTA_41BB_PATHWAY 0 0
Category members Pathway Pathway_904 PID_IL12_STAT4_PATHWAY 0 0
Category members Pathway Pathway_937 BIOCARTA_TOLL_PATHWAY 0 0
Category members Pathway Pathway_966 BIOCARTA_D4GDI_PATHWAY 0 0
Category members Pathway Pathway_986 PID_CD40_PATHWAY 0 0
Category members Pathway Pathway_998 BIOCARTA_AT1R_PATHWAY 0 0
Category members Pathway Pathway_999 SA_B_CELL_RECEPTOR_COMPLEXES 0 0
Category members GO Category GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001774 microglial cell activation Database 0
Category members GO Category GO:0001938 positive regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0002755 MyD88-dependent toll-like receptor signaling pathway Database 0
Category members GO Category GO:0003151 outflow tract morphogenesis Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0005100 Rho GTPase activator activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0007612 learning Database 0
Category members GO Category GO:0007623 circadian rhythm Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009987 cellular process Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0031103 axon regeneration Database 0
Category members GO Category GO:0031953 negative regulation of protein autophosphorylation Database 0
Category members GO Category GO:0032321 positive regulation of Rho GTPase activity Database 0
Category members GO Category GO:0034097 response to cytokine Database 0
Category members GO Category GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway Database 0
Category members GO Category GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway Database 0
Category members GO Category GO:0043525 positive regulation of neuron apoptotic process Database 0
Category members GO Category GO:0045740 positive regulation of DNA replication Database 0
Category members GO Category GO:0051403 stress-activated MAPK cascade Database 0
Category members GO Category GO:0051591 response to cAMP Database 0
Category members GO Category GO:0051899 membrane depolarization Database 0
Category members GO Category GO:0060395 SMAD protein signal transduction Database 0
Category members GO Category GO:0070412 R-SMAD binding Database 0
Category members GO Category GO:0071277 cellular response to calcium ion Database 0


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