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Query: IRS1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IRS1 0 -0.078

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IRS1 Phosphorylation S1101 -0.078 _HSS(ph)ETFSSTPSATR_

Background Information for IRS1:


Pubmed-IRS1 »
Uniprot-IRS1 »
Biogrid-IRS1 »
ProteomicsDB-IRS1 »

Tumorportal-IRS1 »
COSMIC-IRS1 »
GenomeRNAi-IRS1 »
Genecards-IRS1


Protein-protein Interactions for IRS1
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in IRS1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PH_domain IPR001849 0.14
Category members Insln_rcpt_S1 IPR002404 0


Protein complexes (CORUM database) featuring IRS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2577 Sam68-p85 P13K-IRS-1-IR signaling complex Database 0.04


Categories featuring IRS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members Pathway Pathway_509 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 0 0.62
Category members Pathway Pathway_1078 PID_S1P_S1P2_PATHWAY 0 0.62
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_603 PID_IGF1_PATHWAY 0 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_604 REACTOME_PI3K_AKT_ACTIVATION 0 0.32
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members GO Category GO:0034504 protein localization to nucleus Database 0.15
Category members GO Category GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity Database 0.1
Category members Pathway Pathway_601 PID_IL2_1PATHWAY 0 0.1
Category members GO Category GO:0046628 positive regulation of insulin receptor signaling pathway Database 0.08
Category members Disease phenotype DIABETES_MELLITUS_NONINSULIN-DEPENDENT DIABETES MELLITUS NONINSULIN-DEPENDENT Database 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway Database 0.04
Category members GO Category GO:0010907 positive regulation of glucose metabolic process Database 0.04
Category members Pathway Pathway_1115 REACTOME_SOS_MEDIATED_SIGNALLING 0 0.04
Category members GO Category GO:0048009 insulin-like growth factor receptor signaling pathway Database 0.04
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members Pathway Pathway_521 PID_AVB3_INTEGRIN_PATHWAY 0 0.03
Category members Pathway Pathway_1058 REACTOME_SIGNAL_ATTENUATION 0 0
Category members Pathway Pathway_1134 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING 0 0
Category members Pathway Pathway_176 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 0 0
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_212 BIOCARTA_IGF1R_PATHWAY 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_40 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_419 PID_IL4_2PATHWAY 0 0
Category members Pathway Pathway_432 PID_SHP2_PATHWAY 0 0
Category members Pathway Pathway_571 PID_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_577 BIOCARTA_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_591 BIOCARTA_IL2RB_PATHWAY 0 0
Category members Pathway Pathway_602 PID_PTP1B_PATHWAY 0 0
Category members Pathway Pathway_616 BIOCARTA_GH_PATHWAY 0 0
Category members Pathway Pathway_632 BIOCARTA_IGF1_PATHWAY 0 0
Category members Pathway Pathway_633 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 0 0
Category members Pathway Pathway_638 BIOCARTA_EIF4_PATHWAY 0 0
Category members Pathway Pathway_643 PID_RET_PATHWAY 0 0
Category members Pathway Pathway_97 KEGG_TYPE_II_DIABETES_MELLITUS 0 0
Category members Pathway Pathway_989 BIOCARTA_IL4_PATHWAY 0 0
Category members GO Category GO:0002053 positive regulation of mesenchymal cell proliferation Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity Database 0
Category members GO Category GO:0005158 insulin receptor binding Database 0
Category members GO Category GO:0005159 insulin-like growth factor receptor binding Database 0
Category members GO Category GO:0005899 insulin receptor complex Database 0
Category members GO Category GO:0005901 caveola Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0014065 phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0016042 lipid catabolic process Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0030879 mammary gland development Database 0
Category members GO Category GO:0032000 positive regulation of fatty acid beta-oxidation Database 0
Category members GO Category GO:0032868 response to insulin Database 0
Category members GO Category GO:0042169 SH2 domain binding Database 0
Category members GO Category GO:0043434 response to peptide hormone Database 0
Category members GO Category GO:0043491 protein kinase B signaling Database 0
Category members GO Category GO:0043548 phosphatidylinositol 3-kinase binding Database 0
Category members GO Category GO:0045725 positive regulation of glycogen biosynthetic process Database 0
Category members GO Category GO:0046326 positive regulation of glucose import Database 0
Category members GO Category GO:0046627 negative regulation of insulin receptor signaling pathway Database 0
Category members GO Category GO:0046676 negative regulation of insulin secretion Database 0


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