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insulin-like growth factor receptor signaling pathway
(GO:0048009)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
TSC2 1 0.810 -0.710
TSC2 1 0.810 -0.710 -0.715
IGF1R 1 -0.490 0.750 1.476 0.714
IGF2R 1 2.250 -1.150 -0.107 0.125
GRB10 0 0.900 -0.860
AKT1 0 -0.050 0.700
AKT1 0 0.860 -0.040
PIK3R1 0 1.910 -1.220 -0.441 0.147
GIGYF1 0 0.890 -1.070
IRS1 0
EIF2AK3 0 0.010 0.340
PLCB1 0 -0.300 -0.220
GIGYF2 0 -0.660 0.630
GIGYF2 0 -0.660 0.630 -0.833 -0.034 -0.175

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
AKT1 Phosphorylation S124 0.252 0.311 _SGS(ph)PSDNSGAEEMEVSLAKPK_
AKT1 Phosphorylation S126 -0.241 _SGSPS(ph)DNSGAEEM(ox)EVSLAK_
AKT1 Ubiquitylation K301 0.988 _EGIK(gl)DGATMK_
EIF2AK3 Phosphorylation S715 0.832 _EHIEIIAPS(ph)PQR_
GIGYF1 Phosphorylation S406 -0.134 _GIQLS(ph)PGVGSSAGPPGDLEDDEGLK_
GIGYF1 Phosphorylation S638 1.005 0.769 _SLS(ph)VPDSGR_
GIGYF1 Phosphorylation S862 0.120 0.978 _S(ph)SPSLSDSYSHLSGRPIR_
GIGYF1 Phosphorylation S863 0.120 0.978 _S(ph)SPSLSDSYSHLSGRPIR_
GIGYF2 Phosphorylation S20 1.394 0.572 _ALSS(ph)GGSITS(ph)PPLSPALPK_
GIGYF2 Phosphorylation T25 -1.198 -0.724 _ALSSGGSIT(ph)SPPLSPALPK_
GIGYF2 Phosphorylation S26 -1.157 -0.630 _ALSSGGSITS(ph)PPLSPALPK_
GIGYF2 Phosphorylation S30 -1.557 -1.373 _ALSSGGSITS(ph)PPLS(ph)PALPK_
GIGYF2 Phosphorylation T404 -0.311 -0.134 _PGT(ph)PSDHQSQEASQFER_
GIGYF2 Ubiquitylation K1007 0.724 -1.404 _ALQQQQQQQQQK(gl)LSGWGNVSKPSGTTK_
GIGYF2 Ubiquitylation K1016 -0.562 _LSGWGNVSK(gl)PSGTTK_
GIGYF2 Ubiquitylation K1106 0.994 _NSNMGFWDDAVK(gl)EVGPR_
GIGYF2 Ubiquitylation K1125 0.915 -0.414 _NNASLSK(gl)SVGVSNR_
GRB10 Phosphorylation S104 -0.985 -0.688 _SIQPQVS(ph)PR_
IGF1R Ubiquitylation K47 1.146 _NDYQQLK(gl)R_
IGF1R Ubiquitylation K1033 5.779 _VAIK(gl)TVNEAASMR_
IGF1R Ubiquitylation K1168 0.191 _K(gl)GGKGLLPVR_
IGF1R Ubiquitylation K1171 0.232 _GGK(gl)GLLPVR_
IGF2R Ubiquitylation K2352 -0.372 0.420 _SSNVSYK(gl)YSK_
IGF2R Ubiquitylation K2394 -0.020 0.221 _EGQENGHITTK(gl)SVK_
IGF2R Phosphorylation S2409 0.107 0.119 _ALSSLHGDDQDS(ph)EDEVLTIPEVK_
IRS1 Phosphorylation S1101 -0.078 _HSS(ph)ETFSSTPSATR_
PLCB1 Phosphorylation S1199 -0.494 _TPS(ph)SEELGGDIPGKEFDTPL_
PLCB1 Phosphorylation S1200 -0.483 _TPSS(ph)EELGGDIPGKEFDTPL_
TSC2 Ubiquitylation K3 -1.397 _(ac)AK(gl)PTSKDSGLK_
TSC2 Ubiquitylation K14 -1.297 _DSGLKEK(gl)FK_
TSC2 Ubiquitylation K69 0.051 _MIGQICEVAK(gl)TK_
TSC2 Ubiquitylation K71 -0.157 _MIGQICEVAKTK(gl)_
TSC2 Ubiquitylation K258 -0.278 _ELCEPCWK(gl)LMR_
TSC2 Ubiquitylation K634 1.610 _LGLPNK(gl)DGVVR_
TSC2 Phosphorylation S950 -0.152 -0.529 _STS(ph)LNERPK_
TSC2 Phosphorylation S1064 -0.927 _SLLGLDSGELQSGPESSSS(ph)PGVHVR_
TSC2 Phosphorylation S1248 -0.604 _SNTDSAVVMEEGS(ph)PGEVPVLVEPPGLEDVEAALGMDRR_
TSC2 Phosphorylation S1329 -0.120 _S(ph)SSSPELQTLQDILGDPGDK_
TSC2 Phosphorylation S1331 -0.262 _SSS(ph)SPELQTLQDILGDPGDKADVGR_
TSC2 Phosphorylation S1332 -0.063 _SSSS(ph)PELQTLQDILGDPGDK_
TSC2 Phosphorylation S1355 0.174 0.351 _ADVGRLS(ph)PEVK_
TSC2 Phosphorylation S1362 0.859 _S(ph)QSGTLDGESAAWSASGEDSR_
TSC2 Phosphorylation S1364 0.522 0.550 _SQS(ph)GTLDGESAAWSASGEDSR_
TSC2 Phosphorylation T1366 0.137 _SQSGT(ph)LDGESAAWSASGEDSR_
TSC2 Phosphorylation S1396 0.498 _S(ph)PSGLRPR_
TSC2 Phosphorylation S1743 0.596 _RLISS(ph)VEDFTEFV_


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