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Query: GRB10

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GRB10 0 -1.673 0.900 -0.860

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GRB10 Phosphorylation S104 -0.985 -0.688 _SIQPQVS(ph)PR_

Background Information for GRB10:


Pubmed-GRB10 »
Uniprot-GRB10 »
Biogrid-GRB10 »
ProteomicsDB-GRB10 »

Tumorportal-GRB10 »
COSMIC-GRB10 »
GenomeRNAi-GRB10 »
Genecards-GRB10


Protein-protein Interactions for GRB10
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait WDR59 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GRB10
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members PH_domain IPR001849 0.14
Category members BPS-dom IPR015042 0.1
Category members SH2 IPR000980 0.05
Category members Ras-assoc IPR000159 0


Protein complexes (CORUM database) featuring GRB10
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GRB10
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members GO Category GO:0042327 positive regulation of phosphorylation Database 0.52
Category members GO Category GO:0042326 negative regulation of phosphorylation Database 0.5
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members Pathway Pathway_603 PID_IGF1_PATHWAY 0 0.39
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0048009 insulin-like growth factor receptor signaling pathway Database 0.04
Category members Pathway Pathway_1058 REACTOME_SIGNAL_ATTENUATION 0 0
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_522 PID_KIT_PATHWAY 0 0
Category members Pathway Pathway_571 PID_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_643 PID_RET_PATHWAY 0 0
Category members GO Category GO:0005070 SH3/SH2 adaptor activity Database 0
Category members GO Category GO:0005158 insulin receptor binding Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0030178 negative regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0032868 response to insulin Database 0
Category members GO Category GO:0045719 negative regulation of glycogen biosynthetic process Database 0
Category members GO Category GO:0046325 negative regulation of glucose import Database 0
Category members GO Category GO:0046627 negative regulation of insulin receptor signaling pathway Database 0


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