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negative regulation of insulin receptor signaling pathway
(GO:0046627)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
GSK3A 2 -1.420 1.510 -1.128 1.091
GSK3A 2 -1.420 1.510
ANKRD26 1 1.060 -0.760
PRKCQ 0 0.410 0.020
PRKCZ 0 -0.290 0.310
GRB10 0 0.900 -0.860
KANK1 0 0.160 -0.720
RPS6KB1 0 0.850 -0.600
INPP5K 0 -0.690 1.160
PRKCA 0 0.750 -0.690 0.349 0.585
PRKCA 0 0.750 -0.690
PRKCD 0 0.250 0.070 0.578 0.427
INPPL1 0 1.690 -0.810
PRKCB 0 0.260 -0.530
PRKCB 0 0.260 -0.530 0.349 0.585
IRS1 0
RELA 0 -1.130 1.600 0.793
PTPN2 0 1.210 -0.730
PTPN1 0 -0.150 0.310 1.066 0.459 0.251 0.322 0.379
ENPP1 0 0.220 -0.270 -0.295 1.478 0.914

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ANKRD26 Phosphorylation S647 0.103 0.567 _ESVNS(ph)PVFGK_
ANKRD26 Ubiquitylation K1607 1.938 _LLVEK(gl)QQSR_
ANKRD26 Ubiquitylation K1674 2.185 _MQQELEK(gl)NITR_
ANKRD26 Ubiquitylation K1722 1.886 _EYVQVLKK(gl)_
GRB10 Phosphorylation S104 -0.985 -0.688 _SIQPQVS(ph)PR_
GSK3A Phosphorylation S9 -0.483 0.010 _TTS(ph)FAESCKPVQQPSAFGSMK_
GSK3A Phosphorylation S21 -0.406 _TSS(ph)FAEPGGGGGGGGGGPGGSASGPGGTGGGK_
GSK3A Ubiquitylation K85 -0.204 _LCDSGELVAIK(gl)K_
GSK3A Ubiquitylation K86 -0.204 _LCDSGELVAIK(gl)K_
GSK3A Ubiquitylation K148 0.396 _ELVAIK(gl)K_
GSK3A Phosphorylation S215 0.296 0.477 _GEPNVS(ph)YICSR_
GSK3A Phosphorylation Y216 0.356 0.376 _GEPNVSY(ph)ICSR_
GSK3A Phosphorylation T390 2.800 2.527 _IQAAAST(ph)PTNATAASDANTGDR_
INPP5K Ubiquitylation K248 -0.741 0.167 _LLFPPTYK(gl)FDR_
INPPL1 Phosphorylation S1003 -1.290 _NSFNNPAYYVLEGVPHQLLPPEPPS(ph)PAR_
IRS1 Phosphorylation S1101 -0.078 _HSS(ph)ETFSSTPSATR_
KANK1 Phosphorylation S325 0.481 0.652 _SYS(ph)AGNASQLEQLSR_
PRKCA Phosphorylation S10 -0.650 0.036 _(ac)ADVFPGNDS(ph)TASQDVANR_
PRKCA Phosphorylation S13 -1.038 0.335 _(ac)ADVFPGNDSTAS(ph)QDVANR_
PRKCA Phosphorylation S226 0.693 0.415 _STLNPQWNES(ph)FTFK_
PRKCA Ubiquitylation K316 -0.522 -0.535 _LGPAGNK(gl)VISPSEDR_
PRKCB Phosphorylation S10 -0.650 0.036 _(ac)ADVFPGNDS(ph)TASQDVANR_
PRKCB Phosphorylation S13 -1.038 0.335 _(ac)ADVFPGNDSTAS(ph)QDVANR_
PRKCB Phosphorylation S226 0.693 0.415 _STLNPQWNES(ph)FTFK_
PRKCB Ubiquitylation K315 0.213 0.518 _ISQGTK(gl)VPEEK_
PRKCD Ubiquitylation K138 -0.141 _SEDEAK(gl)FPTMNR_
PRKCD Ubiquitylation K222 0.185 0.658 _DTIFQK(gl)ER_
PRKCD Phosphorylation S302 -0.240 -0.222 _S(ph)DSASSEPVGIYQGFEK_
PRKCD Phosphorylation S304 0.378 0.289 _RSDS(ph)ASSEPVGIYQGFEK_
PRKCD Phosphorylation S506 -0.213 0.200 _AS(ph)TFCGTPDYIAPEILQGLK_
PRKCD Phosphorylation T507 -0.149 0.240 _AS(ph)TFCGTPDYIAPEILQGLK_
PRKCD Ubiquitylation K641 -2.000 _DYSNFDQEFLNEK(gl)AR_
PRKCD Phosphorylation S645 0.577 0.832 _ARLS(ph)YSDK_
PRKCD Phosphorylation S647 0.886 0.853 _ARLSYS(ph)DK_
PRKCQ Phosphorylation S685 0.911 _ALINS(ph)MDQNMFR_
PRKCZ Phosphorylation T560 -0.884 -1.578 _KQALPPFQPQITDDYGLDNFDTQFTSEPVQLT(ph)PDDEDAIKR_
PTPN1 Phosphorylation S352 0.032 _GS(ph)PLNAAPYGIESMSQDTEVR_
PTPN1 Phosphorylation S365 -0.247 0.956 _GSPLNAAPYGIESMS(ph)QDTEVR_
PTPN1 Phosphorylation S378 1.462 1.262 _VVGGS(ph)LR_
PTPN2 Phosphorylation S304 -0.873 -0.641 _ELSKEDLSPAFDHS(ph)PNK_
RPS6KB1 Ubiquitylation K99 -0.316 _VLGK(gl)GGYGK_
RPS6KB1 Phosphorylation S447 -0.525 -0.458 _TPVS(ph)PVKFSPGDFWGR_


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