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Query: ENPP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ENPP1 0 2.097 0.220 -0.270 -0.295 1.478 0.914

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for ENPP1:


Pubmed-ENPP1 »
Uniprot-ENPP1 »
Biogrid-ENPP1 »
ProteomicsDB-ENPP1 »

Tumorportal-ENPP1 »
COSMIC-ENPP1 »
GenomeRNAi-ENPP1 »
Genecards-ENPP1


Protein-protein Interactions for ENPP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATP6V0D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BZW1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF2B2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FANCE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FNTB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PON2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTCH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ENPP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Somatomedin_B_dom IPR001212 0
Category members DNA/RNA_non-sp_Endonuclease IPR001604 0
Category members Phosphodiest/P_Trfase IPR002591 0
Category members Alkaline_phosphatase_core IPR017850 0
Category members Somatomedin_B_chordata IPR020436 0
Category members Extracellular_endonuc_su_A IPR020821 0


Protein complexes (CORUM database) featuring ENPP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ENPP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0006955 immune response Database 1.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0006767 water-soluble vitamin metabolic process Database 0.27
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members GO Category GO:0006766 vitamin metabolic process Database 0.23
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members Pathway Pathway_279 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS 0 0.18
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0045599 negative regulation of fat cell differentiation Database 0.13
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0006796 phosphate-containing compound metabolic process Database 0.07
Category members Disease phenotype DIABETES_MELLITUS_NONINSULIN-DEPENDENT DIABETES MELLITUS NONINSULIN-DEPENDENT Database 0.05
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0004528 phosphodiesterase I activity Database 0.03
Category members Pathway Pathway_101 KEGG_RIBOFLAVIN_METABOLISM 0 0
Category members Pathway Pathway_280 KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS 0 0
Category members Pathway Pathway_281 KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM 0 0
Category members Pathway Pathway_60 KEGG_STARCH_AND_SUCROSE_METABOLISM 0 0
Category members Disease phenotype Autosomal_recessive_hypophosphatemic_rickets Autosomal recessive hypophosphatemic rickets Database 0
Category members Disease phenotype Generalized_arterial_calcification_of_infancy Generalized arterial calcification of infancy Database 0
Category members GO Category GO:0004551 nucleotide diphosphatase activity Database 0
Category members GO Category GO:0005044 scavenger receptor activity Database 0
Category members GO Category GO:0005158 insulin receptor binding Database 0
Category members GO Category GO:0006091 generation of precursor metabolites and energy Database 0
Category members GO Category GO:0006771 riboflavin metabolic process Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0009143 nucleoside triphosphate catabolic process Database 0
Category members GO Category GO:0030247 polysaccharide binding Database 0
Category members GO Category GO:0030279 negative regulation of ossification Database 0
Category members GO Category GO:0030500 regulation of bone mineralization Database 0
Category members GO Category GO:0030643 cellular phosphate ion homeostasis Database 0
Category members GO Category GO:0030730 sequestering of triglyceride Database 0
Category members GO Category GO:0031214 biomineral tissue development Database 0
Category members GO Category GO:0031953 negative regulation of protein autophosphorylation Database 0
Category members GO Category GO:0035529 NADH pyrophosphatase activity Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0045719 negative regulation of glycogen biosynthetic process Database 0
Category members GO Category GO:0046325 negative regulation of glucose import Database 0
Category members GO Category GO:0046627 negative regulation of insulin receptor signaling pathway Database 0
Category members GO Category GO:0046849 bone remodeling Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0047429 nucleoside-triphosphate diphosphatase activity Database 0
Category members GO Category GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process Database 0
Category members GO Category GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding Database 0


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