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Query: INPP5K

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
INPP5K 0 0.586 -0.690 1.160

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
INPP5K Ubiquitylation K248 -0.741 0.167 _LLFPPTYK(gl)FDR_

Background Information for INPP5K:


Pubmed-INPP5K »
Uniprot-INPP5K »
Biogrid-INPP5K »
ProteomicsDB-INPP5K »

Tumorportal-INPP5K »
COSMIC-INPP5K »
GenomeRNAi-INPP5K »
Genecards-INPP5K


Protein-protein Interactions for INPP5K
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AAMP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C10orf47 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INPP5K Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PVRL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDYHV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in INPP5K
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members IPPc IPR000300 0.1
Category members Endo/exonuclease/phosphatase IPR005135 0


Protein complexes (CORUM database) featuring INPP5K
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2639 HES1 promoter-Notch enhancer complex Database 0.45


Categories featuring INPP5K
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0046855 inositol phosphate dephosphorylation Database 0.58
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0046856 phosphatidylinositol dephosphorylation Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0001726 ruffle Database 0.33
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members Pathway Pathway_106 KEGG_INOSITOL_PHOSPHATE_METABOLISM 0 0.28
Category members GO Category GO:0005979 regulation of glycogen biosynthetic process Database 0.26
Category members GO Category GO:0033137 negative regulation of peptidyl-serine phosphorylation Database 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0034594 phosphatidylinositol trisphosphate phosphatase activity Database 0.18
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members GO Category GO:0005802 trans-Golgi network Database 0.13
Category members GO Category GO:0043922 negative regulation by host of viral transcription Database 0.12
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0006661 phosphatidylinositol biosynthetic process Database 0.06
Category members GO Category GO:0001933 negative regulation of protein phosphorylation Database 0.04
Category members Pathway Pathway_103 REACTOME_PI_METABOLISM 0 0.04
Category members GO Category GO:0071356 cellular response to tumor necrosis factor Database 0.03
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_102 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_488 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 0
Category members GO Category GO:0004445 inositol-polyphosphate 5-phosphatase activity Database 0
Category members GO Category GO:0005000 vasopressin receptor activity Database 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0
Category members GO Category GO:0006644 phospholipid metabolic process Database 0
Category members GO Category GO:0010801 negative regulation of peptidyl-threonine phosphorylation Database 0
Category members GO Category GO:0010829 negative regulation of glucose transport Database 0
Category members GO Category GO:0016311 dephosphorylation Database 0
Category members GO Category GO:0032868 response to insulin Database 0
Category members GO Category GO:0032870 cellular response to hormone stimulus Database 0
Category members GO Category GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Database 0
Category members GO Category GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity Database 0
Category members GO Category GO:0035305 negative regulation of dephosphorylation Database 0
Category members GO Category GO:0035810 positive regulation of urine volume Database 0
Category members GO Category GO:0042577 lipid phosphatase activity Database 0
Category members GO Category GO:0043407 negative regulation of MAP kinase activity Database 0
Category members GO Category GO:0045719 negative regulation of glycogen biosynthetic process Database 0
Category members GO Category GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Database 0
Category members GO Category GO:0046627 negative regulation of insulin receptor signaling pathway Database 0
Category members GO Category GO:0051497 negative regulation of stress fiber assembly Database 0
Category members GO Category GO:0051898 negative regulation of protein kinase B signaling Database 0
Category members GO Category GO:0051926 negative regulation of calcium ion transport Database 0
Category members GO Category GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity Database 0
Category members GO Category GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Database 0
Category members GO Category GO:0071320 cellular response to cAMP Database 0
Category members GO Category GO:0071364 cellular response to epidermal growth factor stimulus Database 0


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