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Query: PRKCZ

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRKCZ 0 -2.152 -0.290 0.310

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRKCZ Phosphorylation T560 -0.884 -1.578 _KQALPPFQPQITDDYGLDNFDTQFTSEPVQLT(ph)PDDEDAIKR_

Background Information for PRKCZ:


Pubmed-PRKCZ »
Uniprot-PRKCZ »
Biogrid-PRKCZ »
ProteomicsDB-PRKCZ »

Tumorportal-PRKCZ »
COSMIC-PRKCZ »
GenomeRNAi-PRKCZ »
Genecards-PRKCZ


Protein-protein Interactions for PRKCZ
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PARD6B Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKCZ Cat. description Hein, Mann, Cell 2015
Category members IP bait PARD6B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRKCZ
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PE/DAG-bd IPR002219 0.63
Category members DAG/PE-bd IPR020454 0.18
Category members Kinase-like_dom IPR011009 0.03
Category members OPR_PB1 IPR000270 0
Category members Prot_kinase_dom IPR000719 0
Category members AGC-kinase_C IPR000961 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members PKC_zeta IPR012233 0
Category members Pkinase_C IPR017892 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring PRKCZ
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2226 MutS-alpha-PK-zeta complex Database 0.13


Categories featuring PRKCZ
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031252 cell leading edge Database 2.52
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_455 PID_INSULIN_GLUCOSE_PATHWAY 0 1.7
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0030010 establishment of cell polarity Database 0.91
Category members Pathway Pathway_63 BIOCARTA_PTDINS_PATHWAY 0 0.91
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_792 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION 0 0.75
Category members GO Category GO:0005923 tight junction Database 0.69
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0000226 microtubule cytoskeleton organization Database 0.5
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_603 PID_IGF1_PATHWAY 0 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0031532 actin cytoskeleton reorganization Database 0.29
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members Pathway Pathway_957 PID_AMB2_NEUTROPHILS_PATHWAY 0 0.2
Category members GO Category GO:0047496 vesicle transport along microtubule Database 0.19
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members Pathway Pathway_555 PID_NEPHRIN_NEPH1_PATHWAY 0 0.17
Category members Pathway Pathway_685 PID_RAS_PATHWAY 0 0.14
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0007166 cell surface receptor signaling pathway Database 0.1
Category members Pathway Pathway_417 PID_WNT_NONCANONICAL_PATHWAY 0 0.09
Category members GO Category GO:0004697 protein kinase C activity Database 0.09
Category members GO Category GO:0046628 positive regulation of insulin receptor signaling pathway Database 0.08
Category members GO Category GO:0035748 myelin sheath abaxonal region Database 0.06
Category members GO Category GO:0007616 long-term memory Database 0.06
Category members GO Category GO:0034613 cellular protein localization Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Pathway Pathway_644 PID_TRKR_PATHWAY 0 0.04
Category members GO Category GO:0043560 insulin receptor substrate binding Database 0.03
Category members Pathway Pathway_642 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE 0 0.02
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation Database 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_430 PID_TXA2PATHWAY 0 0
Category members Pathway Pathway_571 PID_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_585 PID_IL2_PI3K_PATHWAY 0 0
Category members Pathway Pathway_631 PID_IL1_PATHWAY 0 0
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members Pathway Pathway_734 PID_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Pathway Pathway_97 KEGG_TYPE_II_DIABETES_MELLITUS 0 0
Category members GO Category GO:0001954 positive regulation of cell-matrix adhesion Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0015459 potassium channel regulator activity Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0031333 negative regulation of protein complex assembly Database 0
Category members GO Category GO:0031584 activation of phospholipase D activity Database 0
Category members GO Category GO:0032148 activation of protein kinase B activity Database 0
Category members GO Category GO:0032753 positive regulation of interleukin-4 production Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0043274 phospholipase binding Database 0
Category members GO Category GO:0045179 apical cortex Database 0
Category members GO Category GO:0045630 positive regulation of T-helper 2 cell differentiation Database 0
Category members GO Category GO:0046326 positive regulation of glucose import Database 0
Category members GO Category GO:0046627 negative regulation of insulin receptor signaling pathway Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050806 positive regulation of synaptic transmission Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0051222 positive regulation of protein transport Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0
Category members GO Category GO:0051346 negative regulation of hydrolase activity Database 0
Category members GO Category GO:0051899 membrane depolarization Database 0
Category members GO Category GO:0060081 membrane hyperpolarization Database 0
Category members GO Category GO:0060291 long-term synaptic potentiation Database 0
Category members GO Category GO:0070528 protein kinase C signaling Database 0


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