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Query: INPPL1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
INPPL1 0 -1.290 1.690 -0.810

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
INPPL1 Phosphorylation S1003 -1.290 _NSFNNPAYYVLEGVPHQLLPPEPPS(ph)PAR_

Background Information for INPPL1:


Pubmed-INPPL1 »
Uniprot-INPPL1 »
Biogrid-INPPL1 »
ProteomicsDB-INPPL1 »

Tumorportal-INPPL1 »
COSMIC-INPPL1 »
GenomeRNAi-INPPL1 »
Genecards-INPPL1


Protein-protein Interactions for INPPL1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACOT12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ALKBH3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARFGAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATP6V0D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BHMT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C17orf60 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPYSL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EEF1G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRINL1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAP3K13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NARFL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCYT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLIN5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPM1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRM2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SAMD4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC22A9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM184B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPD52L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in INPPL1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members IPPc IPR000300 0.1
Category members SH2 IPR000980 0.05
Category members SAM IPR001660 0
Category members Endo/exonuclease/phosphatase IPR005135 0
Category members SAM_2 IPR011510 0
Category members SAM/pointed IPR013761 0
Category members SAM_type1 IPR021129 0


Protein complexes (CORUM database) featuring INPPL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring INPPL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members Pathway Pathway_509 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 0 0.62
Category members GO Category GO:0046856 phosphatidylinositol dephosphorylation Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members Pathway Pathway_510 SIG_CHEMOTAXIS 0 0.28
Category members Pathway Pathway_106 KEGG_INOSITOL_PHOSPHATE_METABOLISM 0 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members Pathway Pathway_508 BIOCARTA_IGF1MTOR_PATHWAY 0 0.25
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members Pathway Pathway_503 REACTOME_IL_RECEPTOR_SHC_SIGNALING 0 0.08
Category members GO Category GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway Database 0.08
Category members GO Category GO:0007015 actin filament organization Database 0.08
Category members GO Category GO:0006661 phosphatidylinositol biosynthetic process Database 0.06
Category members GO Category GO:0030175 filopodium Database 0.05
Category members Disease phenotype DIABETES_MELLITUS_NONINSULIN-DEPENDENT DIABETES MELLITUS NONINSULIN-DEPENDENT Database 0.05
Category members Pathway Pathway_511 PID_EPHA2_FWD_PATHWAY 0 0.05
Category members GO Category GO:0001958 endochondral ossification Database 0.04
Category members GO Category GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding Database 0.04
Category members GO Category GO:0010977 negative regulation of neuron projection development Database 0.04
Category members Pathway Pathway_103 REACTOME_PI_METABOLISM 0 0.04
Category members GO Category GO:0008156 negative regulation of DNA replication Database 0.03
Category members GO Category GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway Database 0.01
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_102 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_488 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 0
Category members Pathway Pathway_502 PID_PI3KCI_PATHWAY 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_506 REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 0 0
Category members Pathway Pathway_512 REACTOME_IL_2_SIGNALING 0 0
Category members GO Category GO:0004445 inositol-polyphosphate 5-phosphatase activity Database 0
Category members GO Category GO:0006644 phospholipid metabolic process Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0017124 SH3 domain binding Database 0
Category members GO Category GO:0032868 response to insulin Database 0
Category members GO Category GO:0032957 inositol trisphosphate metabolic process Database 0
Category members GO Category GO:0042169 SH2 domain binding Database 0
Category members GO Category GO:0043407 negative regulation of MAP kinase activity Database 0
Category members GO Category GO:0043647 inositol phosphate metabolic process Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0046627 negative regulation of insulin receptor signaling pathway Database 0


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