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Query: PRKCA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRKCA 0 0.985 0.750 -0.690
PRKCA 0 0.985 0.750 -0.690 0.349 0.585

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRKCA Phosphorylation S226 0.693 0.415 _STLNPQWNES(ph)FTFK_
PRKCA Phosphorylation S13 -1.038 0.335 _(ac)ADVFPGNDSTAS(ph)QDVANR_
PRKCA Phosphorylation S10 -0.650 0.036 _(ac)ADVFPGNDS(ph)TASQDVANR_
PRKCA Ubiquitylation K316 -0.522 -0.535 _LGPAGNK(gl)VISPSEDR_

Background Information for PRKCA:


Pubmed-PRKCA »
Uniprot-PRKCA »
Biogrid-PRKCA »
ProteomicsDB-PRKCA »

Tumorportal-PRKCA »
COSMIC-PRKCA »
GenomeRNAi-PRKCA »
Genecards-PRKCA


Protein-protein Interactions for PRKCA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CYP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKCA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAS2R7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRKCA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PE/DAG-bd IPR002219 0.63
Category members DAG/PE-bd IPR020454 0.18
Category members Kinase-like_dom IPR011009 0.03
Category members C2_dom IPR000008 0
Category members Prot_kinase_dom IPR000719 0
Category members AGC-kinase_C IPR000961 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Protein_kinase_C_a/b/g IPR014375 0
Category members Pkinase_C IPR017892 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring PRKCA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2537 PKC-alpha-PLD1-PLC-gamma-2 signaling complex, lacritin stimulated Database 0


Categories featuring PRKCA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members Pathway Pathway_366 BIOCARTA_TEL_PATHWAY 0 1.44
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_240 BIOCARTA_PAR1_PATHWAY 0 1.11
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_662 PID_IL8_CXCR2_PATHWAY 0 0.62
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_677 BIOCARTA_MYOSIN_PATHWAY 0 0.53
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members Pathway Pathway_1026 KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 0 0.45
Category members Pathway Pathway_187 KEGG_VIBRIO_CHOLERAE_INFECTION 0 0.44
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members Pathway Pathway_286 KEGG_LONG_TERM_DEPRESSION 0 0.31
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members Pathway Pathway_1093 PID_SYNDECAN_4_PATHWAY 0 0.28
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0007603 phototransduction, visible light Database 0.25
Category members Pathway Pathway_964 BIOCARTA_CHEMICAL_PATHWAY 0 0.24
Category members Pathway Pathway_228 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS 0 0.24
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0002159 desmosome assembly Database 0.21
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members Pathway Pathway_232 KEGG_LONG_TERM_POTENTIATION 0 0.21
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members GO Category GO:0045766 positive regulation of angiogenesis Database 0.19
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_428 PID_THROMBIN_PAR1_PATHWAY 0 0.18
Category members Pathway Pathway_1011 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 0 0.18
Category members Pathway Pathway_705 PID_CD8_TCR_PATHWAY 0 0.17
Category members Pathway Pathway_686 BIOCARTA_BCR_PATHWAY 0 0.16
Category members Pathway Pathway_685 PID_RAS_PATHWAY 0 0.14
Category members Pathway Pathway_1067 BIOCARTA_CBL_PATHWAY 0 0.14
Category members GO Category GO:0002062 chondrocyte differentiation Database 0.13
Category members Pathway Pathway_1155 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS 0 0.13
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members Pathway Pathway_233 KEGG_CALCIUM_SIGNALING_PATHWAY 0 0.13
Category members Pathway Pathway_681 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE 0 0.13
Category members Pathway Pathway_698 BIOCARTA_CALCINEURIN_PATHWAY 0 0.11
Category members Pathway Pathway_525 BIOCARTA_CXCR4_PATHWAY 0 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members Pathway Pathway_499 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 0 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0043536 positive regulation of blood vessel endothelial cell migration Database 0.09
Category members Pathway Pathway_626 PID_A6B1_A6B4_INTEGRIN_PATHWAY 0 0.09
Category members Pathway Pathway_270 REACTOME_REGULATION_OF_INSULIN_SECRETION 0 0.09
Category members GO Category GO:0004697 protein kinase C activity Database 0.09
Category members Pathway Pathway_578 BIOCARTA_EGF_PATHWAY 0 0.09
Category members Pathway Pathway_584 BIOCARTA_TPO_PATHWAY 0 0.08
Category members GO Category GO:0050930 induction of positive chemotaxis Database 0.08
Category members Pathway Pathway_687 PID_TCR_PATHWAY 0 0.08
Category members GO Category GO:0050729 positive regulation of inflammatory response Database 0.08
Category members Pathway Pathway_1029 BIOCARTA_SRCRPTP_PATHWAY 0 0.08
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members GO Category GO:0050796 regulation of insulin secretion Database 0.06
Category members Pathway Pathway_1003 PID_TCR_RAS_PATHWAY 0 0.05
Category members Pathway Pathway_680 BIOCARTA_SPPA_PATHWAY 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members GO Category GO:0045931 positive regulation of mitotic cell cycle Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_523 BIOCARTA_CCR3_PATHWAY 0 0.04
Category members GO Category GO:0001933 negative regulation of protein phosphorylation Database 0.04
Category members GO Category GO:0010613 positive regulation of cardiac muscle hypertrophy Database 0.04
Category members GO Category GO:0045785 positive regulation of cell adhesion Database 0.04
Category members GO Category GO:0016056 rhodopsin mediated signaling pathway Database 0.04
Category members Pathway Pathway_543 BIOCARTA_TCR_PATHWAY 0 0.03
Category members Pathway Pathway_690 BIOCARTA_CCR5_PATHWAY 0 0.03
Category members Pathway Pathway_630 BIOCARTA_PDGF_PATHWAY 0 0.03
Category members GO Category GO:0070555 response to interleukin-1 Database 0.02
Category members Pathway Pathway_251 REACTOME_DAG_AND_IP3_SIGNALING 0 0.02
Category members Pathway Pathway_663 PID_IL8_CXCR1_PATHWAY 0 0.01
Category members GO Category GO:0034351 negative regulation of glial cell apoptotic process Database 0.01
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0022400 regulation of rhodopsin mediated signaling pathway Database 0
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1051 PID_NFKAPPAB_CANONICAL_PATHWAY 0 0
Category members Pathway Pathway_1094 BIOCARTA_ARENRF2_PATHWAY 0 0
Category members Pathway Pathway_1113 REACTOME_REGULATION_OF_KIT_SIGNALING 0 0
Category members Pathway Pathway_1144 BIOCARTA_MEF2D_PATHWAY 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_176 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 0 0
Category members Pathway Pathway_216 BIOCARTA_EDG1_PATHWAY 0 0
Category members Pathway Pathway_218 BIOCARTA_GPCR_PATHWAY 0 0
Category members Pathway Pathway_222 REACTOME_CA_DEPENDENT_EVENTS 0 0
Category members Pathway Pathway_227 REACTOME_PLC_BETA_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_234 PID_ENDOTHELIN_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_249 BIOCARTA_CREB_PATHWAY 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_261 REACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_421 BIOCARTA_NOS1_PATHWAY 0 0
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0
Category members Pathway Pathway_430 PID_TXA2PATHWAY 0 0
Category members Pathway Pathway_431 PID_VEGFR1_PATHWAY 0 0
Category members Pathway Pathway_436 KEGG_VEGF_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_487 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 0 0
Category members Pathway Pathway_488 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 0
Category members Pathway Pathway_530 KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_556 BIOCARTA_TRKA_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_616 BIOCARTA_GH_PATHWAY 0 0
Category members Pathway Pathway_638 BIOCARTA_EIF4_PATHWAY 0 0
Category members Pathway Pathway_643 PID_RET_PATHWAY 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_682 BIOCARTA_CDMAC_PATHWAY 0 0
Category members Pathway Pathway_691 BIOCARTA_CARDIACEGF_PATHWAY 0 0
Category members Pathway Pathway_693 BIOCARTA_PYK2_PATHWAY 0 0
Category members Pathway Pathway_704 BIOCARTA_BIOPEPTIDES_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_897 PID_CD8_TCR_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_946 PID_RETINOIC_ACID_PATHWAY 0 0
Category members Pathway Pathway_993 BIOCARTA_AGPCR_PATHWAY 0 0
Category members Pathway Pathway_998 BIOCARTA_AT1R_PATHWAY 0 0
Category members GO Category GO:0000188 inactivation of MAPK activity Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001750 photoreceptor outer segment Database 0
Category members GO Category GO:0001938 positive regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0002026 regulation of the force of heart contraction Database 0
Category members GO Category GO:0004698 calcium-dependent protein kinase C activity Database 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0
Category members GO Category GO:0006874 cellular calcium ion homeostasis Database 0
Category members GO Category GO:0006937 regulation of muscle contraction Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007190 activation of adenylate cyclase activity Database 0
Category members GO Category GO:0007194 negative regulation of adenylate cyclase activity Database 0
Category members GO Category GO:0007202 activation of phospholipase C activity Database 0
Category members GO Category GO:0010595 positive regulation of endothelial cell migration Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0030593 neutrophil chemotaxis Database 0
Category members GO Category GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway Database 0
Category members GO Category GO:0031966 mitochondrial membrane Database 0
Category members GO Category GO:0035403 histone kinase activity (H3-T6 specific) Database 0
Category members GO Category GO:0035408 histone H3-T6 phosphorylation Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0036289 peptidyl-serine autophosphorylation Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0045651 positive regulation of macrophage differentiation Database 0
Category members GO Category GO:0046325 negative regulation of glucose import Database 0
Category members GO Category GO:0046627 negative regulation of insulin receptor signaling pathway Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050730 regulation of peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0071322 cellular response to carbohydrate stimulus Database 0


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