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Query: PTPN2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PTPN2 0 -1.514 1.210 -0.730

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PTPN2 Phosphorylation S304 -0.873 -0.641 _ELSKEDLSPAFDHS(ph)PNK_

Background Information for PTPN2:


Pubmed-PTPN2 »
Uniprot-PTPN2 »
Biogrid-PTPN2 »
ProteomicsDB-PTPN2 »

Tumorportal-PTPN2 »
COSMIC-PTPN2 »
GenomeRNAi-PTPN2 »
Genecards-PTPN2


Protein-protein Interactions for PTPN2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PSMC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMD14 Cat. description Hein, Mann, Cell 2015
Category members IP bait PTPN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ASGR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait B3GNT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C3AR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR77 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFSF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PTPN2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Tyr_Pase_rcpt/non-rcpt IPR000242 0
Category members Tyr/Dual-sp_Pase IPR000387 0
Category members Tyr_Pase_cat IPR003595 0
Category members Ptpn1/Ptpn2 IPR012265 0
Category members Prot-tyrosine_phosphatase-like IPR029021 0


Protein complexes (CORUM database) featuring PTPN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2435 ITGA1-ITGB1-PTPN2 complex Database 0


Categories featuring PTPN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members GO Category GO:0005793 endoplasmic reticulum-Golgi intermediate compartment Database 0.74
Category members GO Category GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Database 0.64
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members GO Category GO:0030218 erythrocyte differentiation Database 0.13
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members Pathway Pathway_537 PID_IFNG_PATHWAY 0 0.11
Category members GO Category GO:0070373 negative regulation of ERK1 and ERK2 cascade Database 0.1
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members GO Category GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein Database 0.08
Category members GO Category GO:0060334 regulation of interferon-gamma-mediated signaling pathway Database 0.07
Category members GO Category GO:0019905 syntaxin binding Database 0.05
Category members GO Category GO:0010888 negative regulation of lipid storage Database 0.04
Category members GO Category GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein Database 0.02
Category members Pathway Pathway_906 REACTOME_REGULATION_OF_IFNG_SIGNALING 0 0.01
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_898 REACTOME_INTERFERON_GAMMA_SIGNALING 0 0
Category members Disease phenotype Juvenile_rheumatoid_factor-negative_polyarthritis Juvenile rheumatoid factor-negative polyarthritis Database 0
Category members Disease phenotype Oligoarticular_juvenile_arthritis Oligoarticular juvenile arthritis Database 0
Category members GO Category GO:0004725 protein tyrosine phosphatase activity Database 0
Category members GO Category GO:0004726 non-membrane spanning protein tyrosine phosphatase activity Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway Database 0
Category members GO Category GO:0016311 dephosphorylation Database 0
Category members GO Category GO:0016791 phosphatase activity Database 0
Category members GO Category GO:0030183 B cell differentiation Database 0
Category members GO Category GO:0030217 T cell differentiation Database 0
Category members GO Category GO:0030971 receptor tyrosine kinase binding Database 0
Category members GO Category GO:0035335 peptidyl-tyrosine dephosphorylation Database 0
Category members GO Category GO:0045650 negative regulation of macrophage differentiation Database 0
Category members GO Category GO:0045722 positive regulation of gluconeogenesis Database 0
Category members GO Category GO:0046627 negative regulation of insulin receptor signaling pathway Database 0
Category members GO Category GO:0050728 negative regulation of inflammatory response Database 0
Category members GO Category GO:0050860 negative regulation of T cell receptor signaling pathway Database 0
Category members GO Category GO:0050922 negative regulation of chemotaxis Database 0
Category members GO Category GO:0060333 interferon-gamma-mediated signaling pathway Database 0
Category members GO Category GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway Database 0
Category members GO Category GO:0060339 negative regulation of type I interferon-mediated signaling pathway Database 0
Category members GO Category GO:0070104 negative regulation of interleukin-6-mediated signaling pathway Database 0


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