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Query: IGF2R

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IGF2R 1 0.644 2.250 -1.150 -0.107 0.125

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IGF2R Ubiquitylation K2352 -0.372 0.420 _SSNVSYK(gl)YSK_
IGF2R Ubiquitylation K2394 -0.020 0.221 _EGQENGHITTK(gl)SVK_
IGF2R Phosphorylation S2409 0.107 0.119 _ALSSLHGDDQDS(ph)EDEVLTIPEVK_

Background Information for IGF2R:


Pubmed-IGF2R »
Uniprot-IGF2R »
Biogrid-IGF2R »
ProteomicsDB-IGF2R »

Tumorportal-IGF2R »
COSMIC-IGF2R »
GenomeRNAi-IGF2R »
Genecards-IGF2R


Protein-protein Interactions for IGF2R
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BUB1B Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015
Category members IP bait SPIRE2 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC5 Cat. description Hein, Mann, Cell 2015


Protein Domains in IGF2R
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Man6P_isomerase_rcpt-bd_dom IPR009011 0.25
Category members FN_type2_col-bd IPR000562 0.05
Category members Kringle-like IPR013806 0


Protein complexes (CORUM database) featuring IGF2R
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5280 RAB9-TIP47-MPRI complex Database 0


Categories featuring IGF2R
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0004930 G-protein coupled receptor activity Database 2.1
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_520 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 0 0.78
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0051219 phosphoprotein binding Database 0.33
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0030118 clathrin coat Database 0.12
Category members GO Category GO:0005770 late endosome Database 0.09
Category members GO Category GO:0005537 mannose binding Database 0.07
Category members GO Category GO:0048009 insulin-like growth factor receptor signaling pathway Database 0.04
Category members GO Category GO:0030140 trans-Golgi network transport vesicle Database 0.03
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members Pathway Pathway_74 KEGG_LYSOSOME 0 0
Category members GO Category GO:0001948 glycoprotein binding Database 0
Category members GO Category GO:0001965 G-protein alpha-subunit binding Database 0
Category members GO Category GO:0001972 retinoic acid binding Database 0
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0005010 insulin-like growth factor-activated receptor activity Database 0
Category members GO Category GO:0005215 transporter activity Database 0
Category members GO Category GO:0005520 insulin-like growth factor binding Database 0
Category members GO Category GO:0005641 nuclear envelope lumen Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0006898 receptor-mediated endocytosis Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0030139 endocytic vesicle Database 0
Category members GO Category GO:0031995 insulin-like growth factor II binding Database 0
Category members GO Category GO:0032526 response to retinoic acid Database 0


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