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Query: EIF2AK3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF2AK3 0 1.172 0.010 0.340

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF2AK3 Phosphorylation S715 0.832 _EHIEIIAPS(ph)PQR_

Background Information for EIF2AK3:


Pubmed-EIF2AK3 »
Uniprot-EIF2AK3 »
Biogrid-EIF2AK3 »
ProteomicsDB-EIF2AK3 »

Tumorportal-EIF2AK3 »
COSMIC-EIF2AK3 »
GenomeRNAi-EIF2AK3 »
Genecards-EIF2AK3


Protein-protein Interactions for EIF2AK3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACCN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ACCN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARSG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait B3GNT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C17orf101 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHRNA9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHRND Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DLK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLT8D2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRIA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-DRA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-DRB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCEH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P2RX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDH20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHA12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHB11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHGB4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCN3B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SFTPC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TGIF2LY Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMPRSS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF2AK3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Quinonprotein_ADH-like_supfam IPR011047 0.56
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring EIF2AK3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EIF2AK3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0006987 activation of signaling protein activity involved in unfolded protein response Database 1.26
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members GO Category GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Database 0.91
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members Pathway Pathway_392 REACTOME_PERK_REGULATED_GENE_EXPRESSION 0 0.64
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0017148 negative regulation of translation Database 0.34
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members Pathway Pathway_1174 BIOCARTA_EIF2_PATHWAY 0 0.22
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity Database 0.17
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members GO Category GO:0034976 response to endoplasmic reticulum stress Database 0.06
Category members GO Category GO:0030282 bone mineralization Database 0.06
Category members GO Category GO:0007029 endoplasmic reticulum organization Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0048009 insulin-like growth factor receptor signaling pathway Database 0.04
Category members GO Category GO:0002063 chondrocyte development Database 0.04
Category members GO Category GO:0031642 negative regulation of myelination Database 0.03
Category members GO Category GO:0031016 pancreas development Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0001503 ossification Database 0
Category members GO Category GO:0005623 cell Database 0
Category members GO Category GO:0006926 virus-infected cell apoptotic process Database 0
Category members GO Category GO:0006983 ER overload response Database 0
Category members GO Category GO:0007595 lactation Database 0
Category members GO Category GO:0009967 positive regulation of signal transduction Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0019217 regulation of fatty acid metabolic process Database 0
Category members GO Category GO:0019722 calcium-mediated signaling Database 0
Category members GO Category GO:0030073 insulin secretion Database 0
Category members GO Category GO:0031018 endocrine pancreas development Database 0
Category members GO Category GO:0032055 negative regulation of translation in response to stress Database 0
Category members GO Category GO:0032057 negative regulation of translational initiation in response to stress Database 0
Category members GO Category GO:0032092 positive regulation of protein binding Database 0
Category members GO Category GO:0032933 SREBP signaling pathway Database 0
Category members GO Category GO:0045444 fat cell differentiation Database 0
Category members GO Category GO:0051260 protein homooligomerization Database 0


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