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activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
HSPE1 2 0.080 -0.480 2.561 -2.441 0.905 0.679
PPP1R9A 2 -1.750 3.750 0.672 0.569
VCP 2 1.650 -0.640 -0.182 0.578 -0.596 0.007 -0.036
BAK1 1 0.710 0.160 -0.419 2.039
MAPK9 1 0.110 -0.490
CASP8 1 1.120 -1.090
TRAF2 1 -0.570 0.540
TRAF2 1 -0.570 0.540
PML 1 -0.420 0.350 -0.244 0.322
RPS3 1 -0.940 1.360 0.247 -0.394 0.032 -0.254 -0.093
AIFM1 1 1.570 0.130 0.210 0.652 -1.014 0.280 0.386
GNB2L1 1 1.000 -0.100 0.279 1.704
GNB2L1 1 1.000 -0.100 -0.278 -0.107 -0.424
BAD 0 -0.660 1.190
FAS 0 1.380 -1.070
FAS 0 1.380 -1.070
SENP1 0 -1.070 0.900 0.519 0.698
BAX 0 1.590 -1.170 0.811 0.359
NLRP1 0 -0.960 0.730
BCL2L13 0 0.130 0.000 -0.277 0.159
DNAJA3 0 -0.010 -0.240 0.786 0.226 -0.161 -0.800 -0.347
TPD52L1 0 -1.170 1.190
DAP 0 0.240 -0.420
FAM162A 0 -0.790 0.840 -0.398 -0.477
IFT57 0 -0.190 0.050
TNFRSF10B 0 -0.030 -0.780
EGLN3 0 -1.310 1.790
RIPK1 0 -0.190 0.440
MTCH1 0 0.480 -0.130 -0.093 0.168
PMAIP1 0 0.570 -0.670
S100A8 0 -0.880 1.550 -3.285 -4.740
HSPD1 0 1.020 -0.650 1.151 0.719 -0.757
TERF1 0 -1.080 1.620
CDKN2A 0 -0.080 -0.260 -0.556 -1.080 -3.270 -1.110
S100A9 0 -1.350 2.240 -4.360
DLC1 0 -0.650 0.390
MOAP1 0 -0.480 1.070
MOAP1 0 -0.050 0.360
SMAD3 0 -1.560 1.800
SMAD3 0 0.270 -0.340
PRELID1 0 -0.400 0.060
ROBO1 0 -0.180 -0.120
SPATA5L1 0 0.670 -0.420 -0.864 -0.304
EIF2AK3 0 0.010 0.340
F2R 0 0.220 0.110
LCK 0 -0.490 1.390 0.295 0.576
DIABLO 0 0.740 -0.290 0.517 0.500
DIABLO 0 0.740 -0.290 -0.061
RPS27L 0 0.340 -0.190 0.820 -0.329 -0.404
MAP3K5 0 0.710 -0.770
PDCD6 0 -1.230 2.040 -0.156 -0.537 0.910 -0.243 -0.371

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
AIFM1 Ubiquitylation K111 1.676 _ISGLGLTPEQKQK(gl)_
AIFM1 Ubiquitylation K518 -0.545 -0.262 _ATAQDNPK(gl)SATEQSGTGIR_
BAD Phosphorylation S74 -0.904 -0.452 _HS(ph)SYPAGTEDDEGM(ox)GEEPSPFR_
BAD Phosphorylation S75 -0.914 -0.660 _HSS(ph)YPAGTEDDEGMGEEPSPFR_
BAD Phosphorylation S97 0.056 _S(ph)RSAPPNLWAAQR_
BAD Phosphorylation S99 -0.299 0.161 _S(ph)APPNLWAAQR_
BAD Phosphorylation S118 1.277 1.089 _RM(ox)S(ph)DEFVDSFKK_
BAX Ubiquitylation K57 -1.174 _MGGEAPELALDPVPQDASTK(gl)K_
BAX Ubiquitylation K58 -1.718 -1.174 _MGGEAPELALDPVPQDASTKK(gl)_
BAX Ubiquitylation K64 0.708 1.306 _LSECLK(gl)R_
BCL2L13 Phosphorylation S370 0.684 0.261 _S(ph)SPATSLFVELDEEEVK_
BCL2L13 Phosphorylation S371 0.881 0.261 _S(ph)SPATSLFVELDEEEVK_
BCL2L13 Phosphorylation S420 0.033 _EES(ph)LVEELS(ph)PASEK_
BCL2L13 Phosphorylation S426 1.045 1.136 _EESLVEELS(ph)PASEK_
CASP8 Ubiquitylation K183 1.917 _IINDYEEFSK(gl)ER_
CASP8 Ubiquitylation K461 -2.031 _NMGK(gl)QMPQPTFTLR_
DAP Phosphorylation S2 -0.404 1.136 _(ac)S(ph)SPPEGKLETK_
DAP Phosphorylation S3 -0.404 1.254 _(ac)SS(ph)PPEGKLETK_
DAP Phosphorylation S51 -0.968 0.151 _DKDDQEWESPS(ph)PPKPTVFISGVIAR_
DLC1 Phosphorylation S842 -0.139 _TGS(ph)FHGPGHISLR_
DLC1 Phosphorylation S946 -0.497 _FSDEGDSDSALDSVSPCPSS(ph)PK_
EGLN3 Ubiquitylation K48 -0.501 _VK(gl)QLHCTGALR_
EGLN3 Ubiquitylation K111 -0.831 _LGK(gl)YYVK_
EIF2AK3 Phosphorylation S715 0.832 _EHIEIIAPS(ph)PQR_
F2R Ubiquitylation K421 0.836 0.568 _MDTCSSNLNNSIYK(gl)K_
FAM162A Ubiquitylation K144 -0.327 _LK(gl)EEAAMK_
FAS Phosphorylation S236 -0.027 _ENQGS(ph)HESPTLNPETVAINLSDVDLSK_
FAS Phosphorylation S239 0.266 _ENQGSHES(ph)PTLNPETVAINLSDVDLSK_
FAS Ubiquitylation K343 1.126 _IQTIILK(gl)DITSDSENSNFR_
GNB2L1 Ubiquitylation K38 -0.238 0.350 _DK(gl)TIIMWK_
GNB2L1 Ubiquitylation K106 -0.290 _RFVGHTK(gl)DVLSVAFSSDNR_
GNB2L1 Ubiquitylation K130 0.632 _TIK(gl)LWNTLGVCK_
GNB2L1 Ubiquitylation K175 -0.554 -0.015 _LVK(gl)VWNLANCK_
GNB2L1 Ubiquitylation K183 -0.161 -0.282 _VWNLANCK(gl)_
GNB2L1 Ubiquitylation K185 -0.061 -0.249 _VWNLANCKLK(gl)_
GNB2L1 Ubiquitylation K257 -0.288 _YWLCAATGPSIK(gl)_
GNB2L1 Ubiquitylation K271 0.756 -0.007 _IIVDELK(gl)QEVISTSSK_
HSPD1 Phosphorylation S70 0.210 0.487 _TVIIEQSWGS(ph)PK_
HSPD1 Ubiquitylation K82 -0.300 _DGVTVAK(gl)SIDLK_
HSPD1 Ubiquitylation K87 -0.005 0.292 _SIDLK(gl)DKYK_
HSPD1 Ubiquitylation K130 -0.428 _EGFEK(gl)ISK_
HSPD1 Ubiquitylation K233 0.853 0.024 _GYISPYFINTSK(gl)GQK_
HSPD1 Ubiquitylation K292 0.339 _LK(gl)VGLQVVAVK_
HSPE1 Ubiquitylation K28 -0.993 _SAAETVTK(gl)GGIMLPEK_
HSPE1 Ubiquitylation K36 0.065 2.612 _GGIMLPEK(gl)SQGK_
HSPE1 Ubiquitylation K40 1.037 _GGIMLPEKSQGK(gl)_
IFT57 Ubiquitylation K360 -0.753 _AAQAQLSEAK(gl)ER_
LCK Phosphorylation T37 -0.435 _YRPENTPEPVSTSVSHYGAEPT(ph)TVSPCPSSSAK_
LCK Ubiquitylation K191 -0.112 0.264 _ESETTK(gl)GAYSLSIR_
LCK Ubiquitylation K235 0.323 _AQFDTLQK(gl)LVK_
LCK Ubiquitylation K259 -1.613 _LTTVCPTVK(gl)PQTQGLAK_
MAP3K5 Phosphorylation S1066 -1.241 _SISLPVPVLVEDTSSSSEYGSVS(ph)PDTELKVDPFSFK_
MAP3K5 Phosphorylation S1113 -1.408 -0.562 _TLFLGIPDENFEDHSAPPS(ph)PEEK_
MAPK9 Phosphorylation Y185 3.533 _TACTNFMMTPY(ph)VVTR_
MOAP1 Ubiquitylation K85 -0.296 _EIPGK(gl)GGIWR_
MOAP1 Ubiquitylation K94 -1.573 _VIFK(gl)PPDPDNTFLSR_
MOAP1 Ubiquitylation K202 0.257 _AWQVPDVEK(gl)R_
MOAP1 Ubiquitylation K253 0.067 _ELQVK(gl)YLTTYQKDEEK_
MOAP1 Ubiquitylation K260 0.209 _YLTTYQK(gl)DEEK_
MOAP1 Ubiquitylation K278 -0.026 _LEPLLQK(gl)LVQR_
MOAP1 Ubiquitylation K305 0.289 _LDQVIAGAVHK(gl)TIR_
NLRP1 Ubiquitylation K297 -1.598 _SQDPLVK(gl)R_
PDCD6 Ubiquitylation K112 0.803 -0.435 _TYDRDNSGMIDK(gl)NELK_
PMAIP1 Ubiquitylation K35 -1.475 0.286 _RFGDK(gl)LNFR_
PMAIP1 Ubiquitylation K41 -1.597 0.340 _QK(gl)LLNLISK_
PMAIP1 Ubiquitylation K48 -2.007 -0.586 _LLNLISK(gl)_
PML Ubiquitylation K394 0.515 0.360 _LQDLSSCITQGK(gl)DAAVSKK_
PML Phosphorylation S403 3.141 _KAS(ph)PEAASTPRDPIDVDLPEEAER_
PML Ubiquitylation K476 -0.403 -0.735 _GPSYGEDVSNTTTAQK(gl)R_
PML Phosphorylation S504 -0.198 -0.109 _S(ph)SPEQPRPSTSK_
PML Phosphorylation S505 -0.198 -0.109 _S(ph)SPEQPRPSTSK_
PML Phosphorylation S518 -1.632 -1.605 _AVS(ph)PPHLDGPPS(ph)PR_
PML Phosphorylation S527 -1.392 -1.605 _AVS(ph)PPHLDGPPS(ph)PR_
PML Phosphorylation S530 0.466 0.093 _S(ph)PVIGSEVFLPNSNHVASGAGEAEER_
PML Ubiquitylation K623 -0.784 _IDNETQK(gl)ISQLAAVNR_
PPP1R9A Phosphorylation S160 0.025 _SVHESGQNNRYS(ph)PK_
PPP1R9A Phosphorylation S187 0.567 1.830 _GSTDS(ph)LDSLSSR_
PPP1R9A Phosphorylation S199 0.448 0.288 _TEAVS(ph)PTVSQLSAVFENTDSPSAIISEK_
PPP1R9A Phosphorylation T201 0.540 _TEAVSPT(ph)VSQLSAVFENTDSPSAIISEK_
PPP1R9A Phosphorylation S338 -0.032 0.111 _SEIPS(ph)PQSQLLEDAEANLVGR_
PPP1R9A Phosphorylation T861 0.994 0.737 _RT(ph)SLGEVSK_
PPP1R9A Phosphorylation S862 1.096 1.033 _RTS(ph)LGEVSK_
PRELID1 Ubiquitylation K49 -3.032 0.473 _EVTPDQK(gl)LLSR_
PRELID1 Ubiquitylation K176 -0.493 _LQGEAPSK(gl)TLVETAK_
RIPK1 Ubiquitylation K642 -0.431 _EGIK(gl)GATVGK_
ROBO1 Phosphorylation S944 -0.471 -0.191 _KVPS(ph)FTFTPTVTYQR_
ROBO1 Phosphorylation T946 0.115 0.428 _KVPSFT(ph)FTPTVTYQR_
ROBO1 Phosphorylation T948 0.436 _KVPSFTFT(ph)PTVTYQR_
ROBO1 Phosphorylation T1244 -0.163 _MYLQQDELEEEEDERGPT(ph)PPVR_
RPS27L Ubiquitylation K34 -0.620 _DLLHPSLEEEKKK(gl)_
RPS3 Ubiquitylation K7 -0.351 0.640 _(ac)AVQISK(gl)K(gl)R_
RPS3 Ubiquitylation K8 -0.271 0.892 _(ac)AVQISK(gl)K(gl)R_
RPS3 Ubiquitylation K10 -0.280 0.954 _K(gl)FVADGIFK_
RPS3 Ubiquitylation K62 0.377 1.170 _TQNVLGEK(gl)GRR_
RPS3 Ubiquitylation K75 0.306 0.997 _IRELTAVVQK(gl)R_
RPS3 Ubiquitylation K90 0.875 0.887 _FGFPEGSVELYAEK(gl)VATR_
RPS3 Ubiquitylation K132 2.406 1.406 _FIMESGAK(gl)GCEVVVSGK_
RPS3 Ubiquitylation K141 0.299 1.362 _GCEVVVSGK(gl)LR_
RPS3 Ubiquitylation K185 1.424 _QGVLGIK(gl)VK_
RPS3 Ubiquitylation K197 -0.785 0.209 _IMLPWDPTGK(gl)_
RPS3 Ubiquitylation K202 -0.633 _K(gl)PLPDHVSIVEPK_
RPS3 Phosphorylation T220 -0.052 -0.022 _DEILPT(ph)TPISEQK_
RPS3 Phosphorylation T221 -0.107 0.074 _DEILPTT(ph)PISEQK_
RPS3 Ubiquitylation K230 1.186 -0.281 _GGK(gl)PEPPAM(ox)PQPVPTA_
SENP1 Ubiquitylation K231 -0.099 _NTLK(gl)DSLFK_
SMAD3 Ubiquitylation K13 -0.704 _(ac)SSILPFTPPIVK(gl)R_
SPATA5L1 Ubiquitylation K372 -1.127 _EVVIGTPTLK(gl)QR_
SPATA5L1 Ubiquitylation K477 -1.832 _LK(gl)QSIEWPLK_
SPATA5L1 Ubiquitylation K511 -0.655 _GVLLYGPPGCAK(gl)TTLVR_
SPATA5L1 Ubiquitylation K577 -0.866 _SASK(gl)TGCDVQER_
SPATA5L1 Ubiquitylation K663 -0.274 _LSILK(gl)VCTK_
TERF1 Phosphorylation S11 -0.248 -0.254 _(ac)AEDVSSAAPS(ph)PR_
TNFRSF10B Ubiquitylation K369 -0.724 _KLGLMDNEIK(gl)VAK_
TPD52L1 Phosphorylation T146 0.503 _NSPT(ph)FKSFEER_
TPD52L1 Phosphorylation S149 0.484 0.646 _NSPTFKS(ph)FEER_
TRAF2 Phosphorylation T7 -0.822 -1.190 _(ac)AAASVT(ph)PPGSLELLQPGFSK_
TRAF2 Ubiquitylation K27 -0.253 2.194 _TLLGTK(gl)LEAK_
TRAF2 Ubiquitylation K119 0.519 _GTLK(gl)EYESCHEGR_
TRAF2 Ubiquitylation K176 -1.233 1.022 _APCCGADVK(gl)AHHEVCPK_
TRAF2 Ubiquitylation K207 0.147 0.918 _FQDHVK(gl)TCGK_
TRAF2 Ubiquitylation K481 -0.507 0.417 _MEAK(gl)NSYVR_
VCP Phosphorylation S3 0.795 1.142 _(ac)AS(ph)GADSKGDDLSTAILK_
VCP Phosphorylation S7 0.312 0.941 _(ac)ASGADS(ph)KGDDLSTAILK_
VCP Ubiquitylation K8 -0.439 -0.154 _(ac)ASGADSK(gl)GDDLSTAILK_
VCP Ubiquitylation K18 -0.452 0.181 _GDDLSTAILK(gl)QK_
VCP Ubiquitylation K20 -0.512 0.529 _(ac)ASGADSKGDDLSTAILKQK(gl)_
VCP Ubiquitylation K60 0.678 0.493 _GDTVLLK(gl)GKK_
VCP Ubiquitylation K81 0.084 _EAVCIVLSDDTCSDEK(gl)IR_
VCP Ubiquitylation K109 -0.847 -0.260 _LGDVISIQPCPDVK(gl)YGK(gl)R_
VCP Ubiquitylation K112 -0.736 -0.276 _LGDVISIQPCPDVK(gl)YGK(gl)R_
VCP Ubiquitylation K148 -0.262 -0.087 _K(gl)GDIFLVR_
VCP Ubiquitylation K211 1.383 0.902 _K(gl)QLAQIK_
VCP Ubiquitylation K236 -0.526 -0.178 _AIGVK(gl)PPR_
VCP Ubiquitylation K251 -0.110 _GILLYGPPGTGK(gl)TLIAR_
VCP Ubiquitylation K336 0.522 _IVSQLLTLMDGLK(gl)QR_
VCP Ubiquitylation K386 1.339 0.706 _LEILQIHTK(gl)NM(ox)K_
VCP Ubiquitylation K389 0.568 1.195 _LEILQIHTKNMK(gl)_
VCP Ubiquitylation K505 0.377 0.794 _FLK(gl)FGMTPSK_
VCP Ubiquitylation K524 -0.528 _GVLFYGPPGCGK(gl)TLLAK_
VCP Ubiquitylation K529 -0.250 _GVLFYGPPGCGKTLLAK(gl)_
VCP Ubiquitylation K565 0.645 0.689 _EIFDK(gl)AR_
VCP Ubiquitylation K615 1.209 1.270 _VINQILTEMDGMSTKK(gl)_
VCP Ubiquitylation K651 -1.709 -0.719 _LDQLIYIPLPDEK(gl)SR_
VCP Ubiquitylation K658 0.362 0.711 _VAILK(gl)ANLR_
VCP Ubiquitylation K663 -0.839 _K(gl)SPVAKDVDLEFLAK_
VCP Ubiquitylation K668 -0.536 0.265 _SPVAK(gl)DVDLEFLAK_
VCP Ubiquitylation K696 1.574 1.691 _ACK(gl)LAIR_
VCP Ubiquitylation K754 0.510 0.939 _K(gl)YEMFAQTLQQSR_


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