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Query: EGLN3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EGLN3 0 1.289 -1.310 1.790

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EGLN3 Ubiquitylation K48 -0.501 _VK(gl)QLHCTGALR_
EGLN3 Ubiquitylation K111 -0.831 _LGK(gl)YYVK_

Background Information for EGLN3:


Pubmed-EGLN3 »
Uniprot-EGLN3 »
Biogrid-EGLN3 »
ProteomicsDB-EGLN3 »

Tumorportal-EGLN3 »
COSMIC-EGLN3 »
GenomeRNAi-EGLN3 »
Genecards-EGLN3


Protein-protein Interactions for EGLN3
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in EGLN3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Oxoglu/Fe-dep_dioxygenase IPR005123 0
Category members Pro_4_hyd_alph IPR006620 0


Protein complexes (CORUM database) featuring EGLN3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5277 HIF1A-OS9-EGLN3 complex Database 0


Categories featuring EGLN3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_753 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN 0 0.35
Category members GO Category GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia Database 0.32
Category members Pathway Pathway_762 PID_HIF2PATHWAY 0 0.23
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Database 0.05
Category members GO Category GO:0005506 iron ion binding Database 0.04
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members Pathway Pathway_821 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_976 PID_HIF1A_PATHWAY 0 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Database 0
Category members GO Category GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline Database 0
Category members GO Category GO:0031418 L-ascorbic acid binding Database 0
Category members GO Category GO:0043523 regulation of neuron apoptotic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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