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Query: HSPD1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HSPD1 0 2.992 1.020 -0.650 1.151 0.719 -0.757

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HSPD1 Phosphorylation S70 0.210 0.487 _TVIIEQSWGS(ph)PK_
HSPD1 Ubiquitylation K87 -0.005 0.292 _SIDLK(gl)DKYK_
HSPD1 Ubiquitylation K233 0.853 0.024 _GYISPYFINTSK(gl)GQK_
HSPD1 Ubiquitylation K130 -0.428 _EGFEK(gl)ISK_
HSPD1 Ubiquitylation K82 -0.300 _DGVTVAK(gl)SIDLK_
HSPD1 Ubiquitylation K292 0.339 _LK(gl)VGLQVVAVK_

Background Information for HSPD1:


Pubmed-HSPD1 »
Uniprot-HSPD1 »
Biogrid-HSPD1 »
ProteomicsDB-HSPD1 »

Tumorportal-HSPD1 »
COSMIC-HSPD1 »
GenomeRNAi-HSPD1 »
Genecards-HSPD1


Protein-protein Interactions for HSPD1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCOR Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDKN2AIP Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP170P1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CKAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCLRE1B Cat. description Hein, Mann, Cell 2015
Category members IP bait DDB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXO7 Cat. description Hein, Mann, Cell 2015
Category members IP bait GBA Cat. description Hein, Mann, Cell 2015
Category members IP bait GBAS Cat. description Hein, Mann, Cell 2015
Category members IP bait GNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HAX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HMG20A Cat. description Hein, Mann, Cell 2015
Category members IP bait LAMB3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NIPSNAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RFWD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SKA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA1C Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR5 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ALOXE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATP5F1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCAT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BPHL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C4orf29 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO17 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXRED1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLB1L3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GORASP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GSTK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTPBP5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTPBP8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HARS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IDH3G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait METTL17 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait METTL20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait METTL8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL37 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPS30 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NDUFS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NEU4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OXCT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OXNAD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRAMEF17 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait QTRT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASL10B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPUSD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIRT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIRT4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A43 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFB1M Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THBS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM43 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRUB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TTC39B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YARS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YBEY Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HSPD1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Chaprnin_Cpn60 IPR001844 0.33
Category members Cpn60/TCP-1 IPR002423 0.09
Category members GroEL-like_apical_dom IPR027409 0.09
Category members Chaperone_TCP-1 IPR017998 0.07


Protein complexes (CORUM database) featuring HSPD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2755 17S U2 snRNP Database 1.77


Categories featuring HSPD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0051087 chaperone binding Database 1.69
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005769 early endosome Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0042026 protein refolding Database 0.63
Category members GO Category GO:0006986 response to unfolded protein Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT 0 0.33
Category members GO Category GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex Database 0.3
Category members Pathway Pathway_310 KEGG_RNA_DEGRADATION 0 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0051131 chaperone-mediated protein complex assembly Database 0.24
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members GO Category GO:0050870 positive regulation of T cell activation Database 0.13
Category members GO Category GO:0030141 secretory granule Database 0.11
Category members GO Category GO:0003725 double-stranded RNA binding Database 0.1
Category members GO Category GO:0006458 'de novo' protein folding Database 0.08
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members GO Category GO:0032729 positive regulation of interferon-gamma production Database 0.08
Category members GO Category GO:0042100 B cell proliferation Database 0.08
Category members GO Category GO:0051604 protein maturation Database 0.06
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0032733 positive regulation of interleukin-10 production Database 0.04
Category members GO Category GO:0032755 positive regulation of interleukin-6 production Database 0.04
Category members GO Category GO:0042110 T cell activation Database 0.02
Category members Pathway Pathway_395 KEGG_TYPE_I_DIABETES_MELLITUS 0 0
Category members Pathway Pathway_850 PID_TOLL_ENDOGENOUS_PATHWAY 0 0
Category members GO Category GO:0001530 lipopolysaccharide binding Database 0
Category members GO Category GO:0002755 MyD88-dependent toll-like receptor signaling pathway Database 0
Category members GO Category GO:0003688 DNA replication origin binding Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0030135 coated vesicle Database 0
Category members GO Category GO:0032727 positive regulation of interferon-alpha production Database 0
Category members GO Category GO:0032735 positive regulation of interleukin-12 production Database 0
Category members GO Category GO:0042113 B cell activation Database 0
Category members GO Category GO:0043032 positive regulation of macrophage activation Database 0
Category members GO Category GO:0046696 lipopolysaccharide receptor complex Database 0


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