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Query: TERF1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TERF1 0 1.118 -1.080 1.620

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TERF1 Phosphorylation S11 -0.248 -0.254 _(ac)AEDVSSAAPS(ph)PR_

Background Information for TERF1:


Pubmed-TERF1 »
Uniprot-TERF1 »
Biogrid-TERF1 »
ProteomicsDB-TERF1 »

Tumorportal-TERF1 »
COSMIC-TERF1 »
GenomeRNAi-TERF1 »
Genecards-TERF1


Protein-protein Interactions for TERF1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DCLRE1B Cat. description Hein, Mann, Cell 2015
Category members IP bait HSP90AA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait POT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TERF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TINF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NAGK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PINX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TERF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TERF1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SANT/Myb IPR001005 2.18
Category members Myb-like_dom IPR017877 0.63
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring TERF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1204 Rap1 complex Database 0.04
Category members Corum 1197 TRF1-TIN2 complex Database 0
Category members Corum 1201 TRF1-TIN2 complex Database 0
Category members Corum 1202 TRF1 telomere length regulation complex Database 0
Category members Corum 1206 TRF-Rap1 complex I, 2MD Database 0
Category members Corum 1219 Tankyrin 1-tankyrin 2-TRF1 complex Database 0
Category members Corum 138 Telosome complex Database 0


Categories featuring TERF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Pathway Pathway_1312 REACTOME_PACKAGING_OF_TELOMERE_ENDS 0 4.09
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_366 BIOCARTA_TEL_PATHWAY 0 1.44
Category members GO Category GO:0042162 telomeric DNA binding Database 1.23
Category members GO Category GO:0007004 telomere maintenance via telomerase Database 0.98
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0007094 mitotic spindle assembly checkpoint Database 0.68
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0003691 double-stranded telomeric DNA binding Database 0.62
Category members GO Category GO:0000784 nuclear chromosome, telomeric region Database 0.61
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0000781 chromosome, telomeric region Database 0.16
Category members GO Category GO:0000783 nuclear telomere cap complex Database 0.11
Category members GO Category GO:0010834 telomere maintenance via telomere shortening Database 0.09
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members GO Category GO:0010521 telomerase inhibitor activity Database 0.08
Category members GO Category GO:0045931 positive regulation of mitotic cell cycle Database 0.04
Category members GO Category GO:0008156 negative regulation of DNA replication Database 0.03
Category members GO Category GO:0008301 DNA binding, bending Database 0
Category members GO Category GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process Database 0
Category members GO Category GO:0031116 positive regulation of microtubule polymerization Database 0
Category members GO Category GO:0032211 negative regulation of telomere maintenance via telomerase Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0045840 positive regulation of mitosis Database 0
Category members GO Category GO:0051260 protein homooligomerization Database 0
Category members GO Category GO:0051974 negative regulation of telomerase activity Database 0


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