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Query: FAS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FAS 0 1.392 1.380 -1.070

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FAS Ubiquitylation K343 1.126 _IQTIILK(gl)DITSDSENSNFR_
FAS Phosphorylation S236 -0.027 _ENQGS(ph)HESPTLNPETVAINLSDVDLSK_
FAS Phosphorylation S239 0.266 _ENQGSHES(ph)PTLNPETVAINLSDVDLSK_

Background Information for FAS:


Pubmed-FAS »
Uniprot-FAS »
Biogrid-FAS »
ProteomicsDB-FAS »

Tumorportal-FAS »
COSMIC-FAS »
GenomeRNAi-FAS »
Genecards-FAS


Protein-protein Interactions for FAS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FAS Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FAS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DEATH-like_dom IPR011029 1.15
Category members Death_domain IPR000488 0.08
Category members TNFR/NGFR_Cys_rich_reg IPR001368 0
Category members Fas_rcpt IPR008063 0


Protein complexes (CORUM database) featuring FAS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5473 FAS-FADD-CASP8 complex Database 0
Category members Corum 5799 Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced Database 0
Category members Corum 5800 Death-inducing signaling complex DISC (type I cells associated), stimulated Database 0
Category members Corum 5859 FAS-FADD-CASP8-CASP10 complex Database 0
Category members Corum 5860 FAS-FADD-CASP8 complex Database 0
Category members Corum 5861 FAS-FADD-CASP10 complex Database 0


Categories featuring FAS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members Pathway Pathway_962 BIOCARTA_FAS_PATHWAY 0 1.75
Category members GO Category GO:0006955 immune response Database 1.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members Pathway Pathway_208 PID_TAP63_PATHWAY 0 0.52
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0019900 kinase binding Database 0.45
Category members GO Category GO:0003014 renal system process Database 0.35
Category members GO Category GO:0045637 regulation of myeloid cell differentiation Database 0.32
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0009986 cell surface Database 0.17
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members Pathway Pathway_1082 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS 0 0.16
Category members GO Category GO:0006924 activation-induced cell death of T cells Database 0.16
Category members GO Category GO:0004888 transmembrane signaling receptor activity Database 0.15
Category members Pathway Pathway_1015 PID_HIV_NEF_PATHWAY 0 0.15
Category members Pathway Pathway_894 KEGG_GRAFT_VERSUS_HOST_DISEASE 0 0.12
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members Pathway Pathway_1062 BIOCARTA_PML_PATHWAY 0 0.06
Category members GO Category GO:0051384 response to glucocorticoid Database 0.04
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members Pathway Pathway_446 KEGG_AUTOIMMUNE_THYROID_DISEASE 0 0
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members Pathway Pathway_1017 BIOCARTA_HSP27_PATHWAY 0 0
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1080 BIOCARTA_CTL_PATHWAY 0 0
Category members Pathway Pathway_1081 BIOCARTA_TCAPOPTOSIS_PATHWAY 0 0
Category members Pathway Pathway_1083 BIOCARTA_ASBCELL_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_307 SA_FAS_SIGNALING 0 0
Category members Pathway Pathway_395 KEGG_TYPE_I_DIABETES_MELLITUS 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_591 BIOCARTA_IL2RB_PATHWAY 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_650 PID_FAS_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_905 KEGG_ALLOGRAFT_REJECTION 0 0
Category members Pathway Pathway_959 SA_CASPASE_CASCADE 0 0
Category members Disease phenotype AUTOIMMUNE_LYMPHOPROLIFERATIVE_SYNDROME AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME Database 0
Category members Disease phenotype Juvenile_rheumatoid_factor-negative_polyarthritis Juvenile rheumatoid factor-negative polyarthritis Database 0
Category members Disease phenotype Oligoarticular_juvenile_arthritis Oligoarticular juvenile arthritis Database 0
Category members GO Category GO:0002377 immunoglobulin production Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0006925 inflammatory cell apoptotic process Database 0
Category members GO Category GO:0006927 transformed cell apoptotic process Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors Database 0
Category members GO Category GO:0009636 response to toxic substance Database 0
Category members GO Category GO:0010940 positive regulation of necrotic cell death Database 0
Category members GO Category GO:0019724 B cell mediated immunity Database 0
Category members GO Category GO:0031264 death-inducing signaling complex Database 0
Category members GO Category GO:0031265 CD95 death-inducing signaling complex Database 0
Category members GO Category GO:0032464 positive regulation of protein homooligomerization Database 0
Category members GO Category GO:0043029 T cell homeostasis Database 0
Category members GO Category GO:0045060 negative thymic T cell selection Database 0
Category members GO Category GO:0045619 regulation of lymphocyte differentiation Database 0
Category members GO Category GO:0048536 spleen development Database 0
Category members GO Category GO:0050869 negative regulation of B cell activation Database 0
Category members GO Category GO:0051260 protein homooligomerization Database 0
Category members GO Category GO:0071260 cellular response to mechanical stimulus Database 0
Category members GO Category GO:0071285 cellular response to lithium ion Database 0
Category members GO Category GO:0071455 cellular response to hyperoxia Database 0


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