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Query: AIFM1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AIFM1 1 2.289 1.570 0.130 0.210 0.652 -1.014 0.280 0.386

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AIFM1 Ubiquitylation K518 -0.545 -0.262 _ATAQDNPK(gl)SATEQSGTGIR_
AIFM1 Ubiquitylation K111 1.676 _ISGLGLTPEQKQK(gl)_

Background Information for AIFM1:


Pubmed-AIFM1 »
Uniprot-AIFM1 »
Biogrid-AIFM1 »
ProteomicsDB-AIFM1 »

Tumorportal-AIFM1 »
COSMIC-AIFM1 »
GenomeRNAi-AIFM1 »
Genecards-AIFM1


Protein-protein Interactions for AIFM1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AIFM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AMZ1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C17orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPTC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTPN12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SGPL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THAP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TOR1AIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AIFM1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Pyr_OxRdtase_NAD-bd_dom IPR001327 0.03
Category members FAD_pyr_nucl-diS_OxRdtase IPR013027 0
Category members FAD/NAD-linked_Rdtase_dimer IPR016156 0
Category members Pyr_nucl-diS_OxRdtase_FAD/NAD IPR023753 0


Protein complexes (CORUM database) featuring AIFM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5843 AIF-CYPA-DNA complex Database 0.32


Categories featuring AIFM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Database 0.91
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0005758 mitochondrial intermembrane space Database 0.33
Category members GO Category GO:0006309 apoptotic DNA fragmentation Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members GO Category GO:0050660 flavin adenine dinucleotide binding Database 0.12
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members GO Category GO:0016651 oxidoreductase activity, acting on NAD(P)H Database 0.05
Category members GO Category GO:0045454 cell redox homeostasis Database 0.05
Category members GO Category GO:0032981 mitochondrial respiratory chain complex I assembly Database 0.04
Category members GO Category GO:0009055 electron carrier activity Database 0.02
Category members Pathway Pathway_1012 BIOCARTA_MITOCHONDRIA_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_734 PID_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_737 BIOCARTA_CERAMIDE_PATHWAY 0 0
Category members GO Category GO:0006308 DNA catabolic process Database 0
Category members GO Category GO:0016174 NAD(P)H oxidase activity Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0030182 neuron differentiation Database 0
Category members GO Category GO:0030261 chromosome condensation Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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