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Query: DLC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DLC1 0 0.251 -0.650 0.390

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DLC1 Phosphorylation S842 -0.139 _TGS(ph)FHGPGHISLR_
DLC1 Phosphorylation S946 -0.497 _FSDEGDSDSALDSVSPCPSS(ph)PK_

Background Information for DLC1:


Pubmed-DLC1 »
Uniprot-DLC1 »
Biogrid-DLC1 »
ProteomicsDB-DLC1 »

Tumorportal-DLC1 »
COSMIC-DLC1 »
GenomeRNAi-DLC1 »
Genecards-DLC1


Protein-protein Interactions for DLC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DLC1 Cat. description Hein, Mann, Cell 2015


Protein Domains in DLC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Rho_GTPase_activation_prot IPR008936 0.53
Category members RhoGAP_dom IPR000198 0
Category members START_lipid-bd_dom IPR002913 0
Category members SAM_2 IPR011510 0


Protein complexes (CORUM database) featuring DLC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DLC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members GO Category GO:0030336 negative regulation of cell migration Database 0.85
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0032956 regulation of actin cytoskeleton organization Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members GO Category GO:0048041 focal adhesion assembly Database 0.1
Category members Pathway Pathway_1172 PID_RHOA_REG_PATHWAY 0 0.09
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members GO Category GO:0035024 negative regulation of Rho protein signal transduction Database 0.06
Category members Pathway Pathway_519 REACTOME_SIGNALING_BY_RHO_GTPASES 0 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0003007 heart morphogenesis Database 0
Category members GO Category GO:0005100 Rho GTPase activator activity Database 0
Category members GO Category GO:0005901 caveola Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0008289 lipid binding Database 0
Category members GO Category GO:0008360 regulation of cell shape Database 0
Category members GO Category GO:0021575 hindbrain morphogenesis Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0032321 positive regulation of Rho GTPase activity Database 0
Category members GO Category GO:0035307 positive regulation of protein dephosphorylation Database 0
Category members GO Category GO:0042169 SH2 domain binding Database 0
Category members GO Category GO:0051497 negative regulation of stress fiber assembly Database 0


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