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Query: SMAD3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMAD3 0 1.096 -1.560 1.800
SMAD3 0 1.096 0.270 -0.340

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMAD3 Ubiquitylation K13 -0.704 _(ac)SSILPFTPPIVK(gl)R_

Background Information for SMAD3:


Pubmed-SMAD3 »
Uniprot-SMAD3 »
Biogrid-SMAD3 »
ProteomicsDB-SMAD3 »

Tumorportal-SMAD3 »
COSMIC-SMAD3 »
GenomeRNAi-SMAD3 »
Genecards-SMAD3


Protein-protein Interactions for SMAD3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SMAD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait C18orf1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMAD3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SMAD_FHA_domain IPR008984 0.86
Category members SMAD_dom_Dwarfin-type IPR001132 0
Category members MAD_homology1_Dwarfin-type IPR003619 0
Category members MAD_homology_MH1 IPR013019 0
Category members Interferon_reg_factor-3 IPR019471 0


Protein complexes (CORUM database) featuring SMAD3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2707 SMAD3-SMAD4-FOXO3-FOXG1 complex Database 0.32
Category members Corum 2706 SMAD3-SMAD4-SP1 complex Database 0.11
Category members Corum 2708 SMAD3-SMAD4-cJUN complex Database 0.11
Category members Corum 2754 JUND-FOSB-SMAD3-SMAD4 complex Database 0.11
Category members Corum 2760 SMAD3-SMAD4-FOXO3 complex Database 0.11
Category members Corum 2813 BRCA1-SMAD3 complex Database 0.11
Category members Corum 3205 SMAD3-SKI-NCOR complex Database 0.09
Category members Corum 3961 SMAD3-cSKI-SIN3A-HDAC1 complex Database 0.08
Category members Corum 1831 PIAS3-SMAD3-P300 complex Database 0.07
Category members Corum 2829 RSmad complex Database 0.06
Category members Corum 2761 SMAD3-SMAD4-FOXO1 complex Database 0.05
Category members Corum 2189 Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) Database 0.04
Category members Corum 2762 SMAD3-SMAD4-FOXO4 complex Database 0.04
Category members Corum 1827 PML-SMAD2/3-SARA complex Database 0.01
Category members Corum 1474 SMAD3/4-E2F4/5-p107-DP1 complex Database 0
Category members Corum 1826 SMAD3-HEF1-APC10-CDH1 complex Database 0
Category members Corum 1828 TGF-beta receptor I-Axin-SMAD3 complex Database 0
Category members Corum 2692 SMAD3-SMAD4-cJun-cFos complex Database 0
Category members Corum 2705 SMAD3-SMAD4-CTCF protein-DNA complex Database 0
Category members Corum 2830 TIF1gamma-SMAD2-SMAD3 complex Database 0
Category members Corum 2834 SMAD4-SMAD2-SMAD3 complex Database 0
Category members Corum 2975 SMAD3-E2F4/5-p107-DP1 complex Database 0
Category members Corum 3199 SMAD3-SKI complex Database 0
Category members Corum 3733 SKI-SMAD3 hexameric complex Database 0
Category members Corum 3740 SKI-SMAD3-SMAD4 pentameric complex Database 0
Category members Corum 3750 CREBBP-SMAD3 hexameric complex Database 0
Category members Corum 3754 CREBBP-SMAD3-SMAD4 pentameric complex Database 0
Category members Corum 3959 SMAD3-SMAD4-cSKI, TGF(beta)-dependent Database 0
Category members Corum 3972 SMURF2-SMAD3-SnoN complex, TGF(beta)-dependent Database 0
Category members Corum 5735 TGF-beta receptor-SMAD3 complex Database 0


Categories featuring SMAD3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0005637 nuclear inner membrane Database 1.98
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006955 immune response Database 1.22
Category members GO Category GO:0043130 ubiquitin binding Database 1.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0010694 positive regulation of alkaline phosphatase activity Database 0.65
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members GO Category GO:0001889 liver development Database 0.51
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0048589 developmental growth Database 0.45
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0001102 RNA polymerase II activating transcription factor binding Database 0.31
Category members Disease phenotype COLORECTAL_CANCER COLORECTAL CANCER Database 0.29
Category members GO Category GO:0045668 negative regulation of osteoblast differentiation Database 0.29
Category members Pathway Pathway_794 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 0 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_816 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 0 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0001836 release of cytochrome c from mitochondria Database 0.18
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_802 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 0 0.17
Category members GO Category GO:0032924 activin receptor signaling pathway Database 0.17
Category members GO Category GO:0019902 phosphatase binding Database 0.16
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members GO Category GO:0010718 positive regulation of epithelial to mesenchymal transition Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0070306 lens fiber cell differentiation Database 0.13
Category members GO Category GO:0002076 osteoblast development Database 0.13
Category members GO Category GO:0001707 mesoderm formation Database 0.11
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0045216 cell-cell junction organization Database 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members GO Category GO:0031053 primary miRNA processing Database 0.08
Category members GO Category GO:0001947 heart looping Database 0.08
Category members GO Category GO:0023019 signal transduction involved in regulation of gene expression Database 0.08
Category members Pathway Pathway_808 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION 0 0.08
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members GO Category GO:0032731 positive regulation of interleukin-1 beta production Database 0.08
Category members Pathway Pathway_823 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY 0 0.07
Category members GO Category GO:0007492 endoderm development Database 0.06
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0043235 receptor complex Database 0.04
Category members Pathway Pathway_1131 PID_SMAD2_3PATHWAY 0 0.04
Category members GO Category GO:0001933 negative regulation of protein phosphorylation Database 0.04
Category members Pathway Pathway_1128 BIOCARTA_TGFB_PATHWAY 0 0.04
Category members GO Category GO:0070410 co-SMAD binding Database 0.03
Category members GO Category GO:0035413 positive regulation of catenin import into nucleus Database 0.02
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0042110 T cell activation Database 0.02
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members GO Category GO:0005518 collagen binding Database 0.02
Category members GO Category GO:0045930 negative regulation of mitotic cell cycle Database 0.01
Category members GO Category GO:0048701 embryonic cranial skeleton morphogenesis Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_1044 BIOCARTA_NTHI_PATHWAY 0 0
Category members Pathway Pathway_1210 REACTOME_SIGNALING_BY_NODAL 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_903 BIOCARTA_TOB1_PATHWAY 0 0
Category members Disease phenotype Familial_thoracic_aortic_aneurysm_and_aortic_dissection Familial thoracic aortic aneurysm and aortic dissection Database 0
Category members GO Category GO:0000987 core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0000988 protein binding transcription factor activity Database 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0001649 osteoblast differentiation Database 0
Category members GO Category GO:0001657 ureteric bud development Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001756 somitogenesis Database 0
Category members GO Category GO:0002520 immune system development Database 0
Category members GO Category GO:0005160 transforming growth factor beta receptor binding Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007183 SMAD protein complex assembly Database 0
Category members GO Category GO:0007369 gastrulation Database 0
Category members GO Category GO:0009880 embryonic pattern specification Database 0
Category members GO Category GO:0016202 regulation of striated muscle tissue development Database 0
Category members GO Category GO:0017015 regulation of transforming growth factor beta receptor signaling pathway Database 0
Category members GO Category GO:0019049 evasion or tolerance of host defenses by virus Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0030501 positive regulation of bone mineralization Database 0
Category members GO Category GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Database 0
Category members GO Category GO:0030878 thyroid gland development Database 0
Category members GO Category GO:0031490 chromatin DNA binding Database 0
Category members GO Category GO:0032332 positive regulation of chondrocyte differentiation Database 0
Category members GO Category GO:0032909 regulation of transforming growth factor beta2 production Database 0
Category members GO Category GO:0033689 negative regulation of osteoblast proliferation Database 0
Category members GO Category GO:0038092 nodal signaling pathway Database 0
Category members GO Category GO:0042060 wound healing Database 0
Category members GO Category GO:0042177 negative regulation of protein catabolic process Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0042993 positive regulation of transcription factor import into nucleus Database 0
Category members GO Category GO:0046332 SMAD binding Database 0
Category members GO Category GO:0048340 paraxial mesoderm morphogenesis Database 0
Category members GO Category GO:0048617 embryonic foregut morphogenesis Database 0
Category members GO Category GO:0050678 regulation of epithelial cell proliferation Database 0
Category members GO Category GO:0050728 negative regulation of inflammatory response Database 0
Category members GO Category GO:0050776 regulation of immune response Database 0
Category members GO Category GO:0050927 positive regulation of positive chemotaxis Database 0
Category members GO Category GO:0051098 regulation of binding Database 0
Category members GO Category GO:0051496 positive regulation of stress fiber assembly Database 0
Category members GO Category GO:0051894 positive regulation of focal adhesion assembly Database 0
Category members GO Category GO:0060039 pericardium development Database 0
Category members GO Category GO:0060290 transdifferentiation Database 0
Category members GO Category GO:0061045 negative regulation of wound healing Database 0
Category members GO Category GO:0070412 R-SMAD binding Database 0
Category members GO Category GO:0071141 SMAD protein complex Database 0


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