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REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION
(Pathway_808)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
RPS27A 4 -1.330 2.560 -0.309 0.131 -0.009
UBA52 3 -1.260 2.180 -0.309 0.131 -0.009
UBA52 3 -1.260 2.180
CDK9 2 -1.000 1.130 2.047 1.362 1.840 1.146 0.280
RBL1 1 0.270 -0.950
CCNT2 1 -1.850 3.910
HDAC1 1 -1.980 4.450
HDAC1 1 -1.980 4.450 -0.122 0.307 0.969 0.094 0.191
CCNC 0 0.760 -0.860
CCNT1 0 0.720 -0.430 1.355 1.434
MEN1 0 1.080 -1.150 0.101 0.684 -0.063
MEN1 0 1.080 -1.150 0.395
MEN1 0 1.080 -1.150
MYC 0 0.170 0.550 -2.443 -0.949 -0.454 -1.290
SMAD4 0 0.420 -0.390 0.020 0.556 -0.485
SMAD3 0 -1.560 1.800
SMAD3 0 0.270 -0.340
JUNB 0 0.350 -0.410
SMAD2 0
SP1 0 0.404 0.333 0.650
TFDP1 0 -0.430 0.060 -1.111 0.446 -1.279 -0.496
E2F4 0 0.930 -0.810

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
CCNC Ubiquitylation K117 0.126 _LIAAATSVLK(gl)TR_
CCNT2 Phosphorylation S480 -0.420 _QGQSQAASSSSVTS(ph)PIK_
CCNT2 Phosphorylation S601 -0.068 0.175 _S(ph)PVGLSSDGISSSSSSSR_
CDK9 Ubiquitylation K35 -0.042 _IGQGTFGEVFK(gl)AR_
CDK9 Ubiquitylation K151 -0.345 _DMK(gl)AANVLITR_
CDK9 Ubiquitylation K178 -0.409 -1.058 _AFSLAK(gl)NSQPNR_
CDK9 Ubiquitylation K269 -1.874 _LELVK(gl)GQK_
E2F4 Phosphorylation T14 -2.100 _(ac)AEAGPQAPPPPGT(ph)PSR_
E2F4 Phosphorylation S16 -2.158 -1.655 _(ac)AEAGPQAPPPPGTPS(ph)R_
HDAC1 Ubiquitylation K50 0.036 _K(gl)MEIYRPHK_
HDAC1 Ubiquitylation K66 -0.593 _ANAEEMTK(gl)YHSDDYIK_
HDAC1 Ubiquitylation K74 0.620 -1.473 _YHSDDYIK(gl)FLR_
HDAC1 Ubiquitylation K89 0.749 -0.241 _SIRPDNMSEYSK(gl)QMQR_
HDAC1 Phosphorylation S393 -1.133 -1.144 _M(ox)LPHAPGVQM(ox)QAIPEDAIPEES(ph)GDEDEDDPDKR_
HDAC1 Phosphorylation S409 1.326 1.144 _ISICS(ph)SDKR_
HDAC1 Phosphorylation S410 1.326 1.144 _ISICS(ph)SDKR_
HDAC1 Ubiquitylation K412 0.642 -0.744 _ISICSSDK(gl)R_
JUNB Phosphorylation T255 -0.205 _DAT(ph)PPVS(ph)PINMEDQER_
JUNB Phosphorylation S259 -0.205 _DAT(ph)PPVS(ph)PINMEDQER_
MEN1 Ubiquitylation K8 -1.132 0.088 _AAQK(gl)TLFPLR_
MEN1 Phosphorylation S218 -0.820 _RES(ph)KPEEPPPPK_
MYC Phosphorylation S20 -1.444 -1.145 _PLNVS(ph)FTNR_
MYC Phosphorylation T72 -1.699 -1.813 _FELLPT(ph)PPLS(ph)PSRR_
MYC Phosphorylation S76 -1.777 -1.435 _FELLPTPPLS(ph)PSR_
MYC Phosphorylation S81 0.459 _S(ph)GLCSPSYVAVTPFSLR_
MYC Phosphorylation S85 0.199 0.073 _SGLCS(ph)PSYVAVTPFSLR_
MYC Ubiquitylation K162 -2.475 -1.259 _LVSEK(gl)LASYQAAR_
MYC Phosphorylation S295 -0.903 _SESGS(ph)PSAGGHSKPPHSPLVLK_
MYC Phosphorylation S307 -1.486 _SES(ph)GSPSAGGHSKPPHS(ph)PLVLK_
MYC Ubiquitylation K340 -2.449 _VK(gl)LDSVR_
MYC Ubiquitylation K403 -3.432 _DQIPELENNEK(gl)APK_
RBL1 Phosphorylation S640 -0.916 -1.810 _DMQPLS(ph)PISVHER_
RBL1 Phosphorylation S749 0.935 1.566 _VKS(ph)PVSLTAHSLIGASPK_
RBL1 Ubiquitylation K885 -0.844 _SVLLK(gl)SIPR_
RPS27A Ubiquitylation K6 1.066 0.995 _MQIFVK(gl)TLTGK_
RPS27A Ubiquitylation K11 -0.488 -0.081 _TLTGK(gl)TITLEVEPSDTIENVKAK(gl)_
RPS27A Ubiquitylation K27 -0.882 -0.159 _TLTGK(gl)TITLEVEPSDTIENVK(gl)AK_
RPS27A Ubiquitylation K29 -1.087 -1.029 _AK(gl)IQDK(gl)EGIPPDQQR_
RPS27A Ubiquitylation K33 -0.736 -0.407 _IQDK(gl)EGIPPDQQR_
RPS27A Ubiquitylation K48 -0.062 0.315 _LIFAGK(gl)QLEDGRTLSDYNIQK_
RPS27A Phosphorylation S57 1.909 0.548 _TLS(ph)DYNIQK_
RPS27A Ubiquitylation K63 0.276 0.299 _TLSDYNIQK(gl)ESTLHLVLR_
RPS27A Ubiquitylation K99 0.109 2.111 _VK(gl)LAVLK_
RPS27A Ubiquitylation K104 0.674 2.102 _LAVLK(gl)YYK_
RPS27A Ubiquitylation K107 2.949 3.611 _YYK(gl)VDENGK(gl)ISR_
RPS27A Ubiquitylation K113 1.572 3.672 _YYK(gl)VDENGK(gl)ISR_
RPS27A Ubiquitylation K152 4.747 4.970 _CCLTYCFNK(gl)PEDK_
RPS27A Ubiquitylation K156 4.809 _CCLTYCFNKPEDK(gl)_
SMAD2 Phosphorylation T8 -0.896 -0.885 _(ac)SSILPFT(ph)PPVVK_
SMAD2 Ubiquitylation K13 -0.058 _(ac)SSILPFTPPVVK(gl)R_
SMAD3 Ubiquitylation K13 -0.704 _(ac)SSILPFTPPIVK(gl)R_
SP1 Phosphorylation S2 0.834 1.114 _(ac)S(ph)DQDHSMDEMTAVVK_
SP1 Phosphorylation S7 0.586 0.217 _(ac)SDQDHS(ph)MDEMTAVVK_
SP1 Phosphorylation S56 -0.154 _SSSTGSSSSTGGGGQES(ph)QPSPLALLAATCSR_
SP1 Phosphorylation S59 -0.217 -0.135 _SSSTGSSSSTGGGGQESQPS(ph)PLALLAATCSR_
TFDP1 Phosphorylation S23 -0.667 -0.353 _VFIDQNLS(ph)PGK_
TFDP1 Ubiquitylation K320 -0.549 0.052 _MGMACGLESGSCSAEDLK(gl)MAR_
UBA52 Ubiquitylation K6 1.066 0.995 _MQIFVK(gl)TLTGK_
UBA52 Ubiquitylation K11 -0.488 -0.081 _TLTGK(gl)TITLEVEPSDTIENVKAK(gl)_
UBA52 Ubiquitylation K27 -0.882 -0.159 _TLTGK(gl)TITLEVEPSDTIENVK(gl)AK_
UBA52 Ubiquitylation K29 -1.087 -1.029 _AK(gl)IQDK(gl)EGIPPDQQR_
UBA52 Ubiquitylation K33 -0.736 -0.407 _IQDK(gl)EGIPPDQQR_
UBA52 Ubiquitylation K48 -0.062 0.315 _LIFAGK(gl)QLEDGRTLSDYNIQK_
UBA52 Phosphorylation S57 1.909 0.548 _TLS(ph)DYNIQK_
UBA52 Ubiquitylation K63 0.276 0.299 _TLSDYNIQK(gl)ESTLHLVLR_
UBA52 Ubiquitylation K93 0.181 2.418 _YNCDK(gl)MICR_
UBA52 Ubiquitylation K99 0.109 2.111 _VK(gl)LAVLK_
UBA52 Ubiquitylation K104 0.674 2.102 _LAVLK(gl)YYK_
UBA52 Ubiquitylation K107 2.949 3.611 _YYK(gl)VDENGK(gl)ISR_
UBA52 Ubiquitylation K113 1.572 3.672 _YYK(gl)VDENGK(gl)ISR_
UBA52 Ubiquitylation K152 4.747 4.970 _CCLTYCFNK(gl)PEDK_
UBA52 Ubiquitylation K156 4.809 _CCLTYCFNKPEDK(gl)_


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