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Query: CDK9

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDK9 2 7.354 -1.000 1.130 2.047 1.362 1.840 1.146 0.280

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDK9 Ubiquitylation K35 -0.042 _IGQGTFGEVFK(gl)AR_
CDK9 Ubiquitylation K151 -0.345 _DMK(gl)AANVLITR_
CDK9 Ubiquitylation K178 -0.409 -1.058 _AFSLAK(gl)NSQPNR_
CDK9 Ubiquitylation K269 -1.874 _LELVK(gl)GQK_

Background Information for CDK9:


Pubmed-CDK9 »
Uniprot-CDK9 »
Biogrid-CDK9 »
ProteomicsDB-CDK9 »

Tumorportal-CDK9 »
COSMIC-CDK9 »
GenomeRNAi-CDK9 »
Genecards-CDK9


Protein-protein Interactions for CDK9
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AFF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CENPA Cat. description Hein, Mann, Cell 2015
Category members IP bait CTR9 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait MLLT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait AFF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HEXIM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HEXIM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDK9
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring CDK9
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1191 RNA pol II containing coactivator complex Tat-SF Database 2.13
Category members Corum 2601 P-TEFb-BRD4-TRAP220 complex Database 1.23
Category members Corum 2599 POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex Database 0.75
Category members Corum 2603 Transcription elongation factor complex (SUPT5H, CDK9, CCNT1) Database 0.7
Category members Corum 2875 BRD4-P-TEFb complex Database 0.7
Category members Corum 2877 BRD4-P-TEFb complex Database 0.7
Category members Corum 2600 BRD4 complex Database 0.63
Category members Corum 2639 HES1 promoter-Notch enhancer complex Database 0.45
Category members Corum 2604 P-TEFb-SKP2 complex Database 0.35
Category members Corum 3229 Heterodimer complex (CDK9, IL6ST) Database 0.11
Category members Corum 2602 P-TEFb-7SKRNA-HEXIM1 complex Database 0.08
Category members Corum 2605 Heterotrimeric complex (CCNT1, CDK9, GRN) Database 0.08
Category members Corum 2873 P-TEFb-7SKRNA-HEXIM1 complex Database 0.08
Category members Corum 2878 P-TEFb-7SKRNA-HEXIM1 complex Database 0.08


Categories featuring CDK9
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0050434 positive regulation of viral transcription Database 4.8
Category members Pathway Pathway_360 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ 0 3.35
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members GO Category GO:0006368 transcription elongation from RNA polymerase II promoter Database 2.03
Category members Pathway Pathway_363 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 0 1.84
Category members Pathway Pathway_367 REACTOME_ELONGATION_ARREST_AND_RECOVERY 0 1.67
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0017069 snRNA binding Database 0.96
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity Database 0.42
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_802 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 0 0.17
Category members GO Category GO:0008024 positive transcription elongation factor complex b Database 0.16
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0031056 regulation of histone modification Database 0.09
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members Pathway Pathway_808 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION 0 0.08
Category members GO Category GO:0004693 cyclin-dependent protein serine/threonine kinase activity Database 0.08
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0006282 regulation of DNA repair Database 0
Category members GO Category GO:0008023 transcription elongation factor complex Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0071157 negative regulation of cell cycle arrest Database 0
Category members GO Category GO:0071345 cellular response to cytokine stimulus Database 0


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