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Query: SMAD2

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMAD2 0 -1.839

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMAD2 Phosphorylation T8 -0.896 -0.885 _(ac)SSILPFT(ph)PPVVK_
SMAD2 Ubiquitylation K13 -0.058 _(ac)SSILPFTPPVVK(gl)R_

Background Information for SMAD2:


Pubmed-SMAD2 »
Uniprot-SMAD2 »
Biogrid-SMAD2 »
ProteomicsDB-SMAD2 »

Tumorportal-SMAD2 »
COSMIC-SMAD2 »
GenomeRNAi-SMAD2 »
Genecards-SMAD2


Protein-protein Interactions for SMAD2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ALDH4A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C18orf1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMAD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMAD2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SMAD_FHA_domain IPR008984 0.86
Category members SMAD_dom_Dwarfin-type IPR001132 0
Category members MAD_homology1_Dwarfin-type IPR003619 0
Category members MAD_homology_MH1 IPR013019 0
Category members Interferon_reg_factor-3 IPR019471 0


Protein complexes (CORUM database) featuring SMAD2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3204 SMAD2-SKI-NCOR complex Database 0.76
Category members Corum 3198 SMAD2-SKI complex Database 0.33
Category members Corum 3729 SKI-SMAD2 hexameric complex Database 0.33
Category members Corum 3739 SKI-SMAD2-SMAD4 pentameric complex Database 0.33
Category members Corum 3749 CREBBP-SMAD2 hexameric complex Database 0.33
Category members Corum 3753 CREBBP-SMAD2-SMAD4 pentameric complex Database 0.33
Category members Corum 2829 RSmad complex Database 0.06
Category members Corum 1827 PML-SMAD2/3-SARA complex Database 0.01
Category members Corum 2830 TIF1gamma-SMAD2-SMAD3 complex Database 0
Category members Corum 2834 SMAD4-SMAD2-SMAD3 complex Database 0
Category members Corum 3038 SMAD2-SMAD4-FAST1 complex Database 0
Category members Corum 3039 SMAD2-FAST1 complex Database 0


Categories featuring SMAD2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0048589 developmental growth Database 0.45
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_794 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 0 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members Pathway Pathway_816 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 0 0.23
Category members GO Category GO:0060021 palate development Database 0.23
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members Pathway Pathway_802 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 0 0.17
Category members GO Category GO:0032924 activin receptor signaling pathway Database 0.17
Category members GO Category GO:0019902 phosphatase binding Database 0.16
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members GO Category GO:0009749 response to glucose Database 0.13
Category members GO Category GO:0010718 positive regulation of epithelial to mesenchymal transition Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0001707 mesoderm formation Database 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members GO Category GO:0001706 endoderm formation Database 0.08
Category members GO Category GO:0031053 primary miRNA processing Database 0.08
Category members GO Category GO:0023019 signal transduction involved in regulation of gene expression Database 0.08
Category members Pathway Pathway_808 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION 0 0.08
Category members GO Category GO:0034713 type I transforming growth factor beta receptor binding Database 0.08
Category members Pathway Pathway_823 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY 0 0.07
Category members GO Category GO:0009952 anterior/posterior pattern specification Database 0.06
Category members GO Category GO:0007492 endoderm development Database 0.06
Category members GO Category GO:0030513 positive regulation of BMP signaling pathway Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_1131 PID_SMAD2_3PATHWAY 0 0.04
Category members Pathway Pathway_1128 BIOCARTA_TGFB_PATHWAY 0 0.04
Category members GO Category GO:0070410 co-SMAD binding Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members GO Category GO:0031016 pancreas development Database 0.01
Category members GO Category GO:0048701 embryonic cranial skeleton morphogenesis Database 0.01
Category members Pathway Pathway_1210 REACTOME_SIGNALING_BY_NODAL 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_718 PID_GLYPICAN_1PATHWAY 0 0
Category members Disease phenotype Congenital_heart_disease Congenital heart disease Database 0
Category members GO Category GO:0001657 ureteric bud development Database 0
Category members GO Category GO:0005160 transforming growth factor beta receptor binding Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007182 common-partner SMAD protein phosphorylation Database 0
Category members GO Category GO:0007183 SMAD protein complex assembly Database 0
Category members GO Category GO:0007352 zygotic specification of dorsal/ventral axis Database 0
Category members GO Category GO:0007369 gastrulation Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0009880 embryonic pattern specification Database 0
Category members GO Category GO:0017015 regulation of transforming growth factor beta receptor signaling pathway Database 0
Category members GO Category GO:0030073 insulin secretion Database 0
Category members GO Category GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Database 0
Category members GO Category GO:0032444 activin responsive factor complex Database 0
Category members GO Category GO:0033613 activating transcription factor binding Database 0
Category members GO Category GO:0035265 organ growth Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0038092 nodal signaling pathway Database 0
Category members GO Category GO:0045165 cell fate commitment Database 0
Category members GO Category GO:0046332 SMAD binding Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048340 paraxial mesoderm morphogenesis Database 0
Category members GO Category GO:0048617 embryonic foregut morphogenesis Database 0
Category members GO Category GO:0051098 regulation of binding Database 0
Category members GO Category GO:0060039 pericardium development Database 0
Category members GO Category GO:0070411 I-SMAD binding Database 0
Category members GO Category GO:0070412 R-SMAD binding Database 0
Category members GO Category GO:0070723 response to cholesterol Database 0
Category members GO Category GO:0071141 SMAD protein complex Database 0


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