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BIOCARTA_TGFB_PATHWAY
(Pathway_1128)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
TAB1 1 1.890 -0.670
TAB1 1 1.890 -0.670 1.657
MAP2K1 1 -1.590 2.780
CREBBP 0 0.840 -0.950 -3.889 -1.071
CDH1 0 0.150 0.280 -0.623
EP300 0 -1.210 1.320 -1.089 -1.694 -0.723
MAPK3 0
TGFB1 0 -0.550 1.050
TGFBR1 0 -0.260 0.020
TGFB3 0 0.900 -0.540
MAP3K7 0 -1.120 1.140 -1.048
SMAD4 0 0.420 -0.390 0.020 0.556 -0.485
ZFYVE9 0 -0.930 0.760
SMAD3 0 -1.560 1.800
SMAD3 0 0.270 -0.340
SMAD2 0

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
CREBBP Phosphorylation S2093 0.037 0.097 _SIS(ph)PSALQDLLR_
EP300 Phosphorylation S1038 -0.672 -0.349 _TEIKEEEDQPSTSATQSS(ph)PAPGQSK_
EP300 Phosphorylation S1726 0.994 0.627 _LGLGLDDESNNQQAAATQS(ph)PGDSRR_
EP300 Phosphorylation S2328 -1.092 0.725 _PQSQPPHSSPS(ph)PR_
MAP2K1 Ubiquitylation K192 -0.205 -0.241 _DVK(gl)PSNILVNSR_
MAP2K1 Phosphorylation S385 0.066 _RSDAEEVDFAGWLCSTIGLNQPS(ph)TPTHAAGV_
MAP2K1 Phosphorylation T386 0.377 _RSDAEEVDFAGWLCSTIGLNQPST(ph)PTHAAGV_
MAP3K7 Phosphorylation S374 0.149 -0.337 _GS(ph)SVESLPPTSEGK_
MAP3K7 Phosphorylation S375 0.171 -0.087 _GSS(ph)VESLPPTSEGK_
MAP3K7 Phosphorylation S389 1.072 1.445 _RMS(ph)ADMSEIEAR_
MAP3K7 Phosphorylation S439 0.246 0.198 _S(ph)IQDLTVTGTEPGQVSSR_
MAP3K7 Ubiquitylation K474 -0.385 -0.242 _MITTSGPTSEK(gl)PTR_
MAP3K7 Ubiquitylation K589 -0.104 _SLSTYYQQCK(gl)K_
MAP3K7 Ubiquitylation K590 -0.551 0.560 _K(gl)QLEVIR_
MAPK3 Phosphorylation Y204 -0.807 -2.487 _IADPEHDHTGFLTEY(ph)VATR_
MAPK3 Ubiquitylation K289 -0.608 _NYLQSLPSKTK(gl)_
SMAD2 Phosphorylation T8 -0.896 -0.885 _(ac)SSILPFT(ph)PPVVK_
SMAD2 Ubiquitylation K13 -0.058 _(ac)SSILPFTPPVVK(gl)R_
SMAD3 Ubiquitylation K13 -0.704 _(ac)SSILPFTPPIVK(gl)R_
TAB1 Phosphorylation S7 -0.170 0.140 _S(ph)LLQSEQQPSWTDDLPLCHLSGVGSASNR_
TAB1 Phosphorylation S16 -0.138 0.069 _SLLQSEQQPS(ph)WTDDLPLCHLSGVGSASNR_
TAB1 Ubiquitylation K186 -1.015 _SYSADGK(gl)GTESHPPEDSWLK_
TAB1 Ubiquitylation K371 0.032 _LSQLGLDAGK(gl)IK_
TAB1 Ubiquitylation K373 -0.007 _LSQLGLDAGKIK(gl)_
TGFB1 Ubiquitylation K50 -0.557 _GQILSK(gl)LR_
TGFB3 Ubiquitylation K50 -0.557 _GQILSK(gl)LR_
TGFBR1 Ubiquitylation K449 -0.991 _VVCEQK(gl)LRPNIPNR_
TGFBR1 Ubiquitylation K502 0.553 0.430 _TLSQLSQQEGIK(gl)M_
ZFYVE9 Ubiquitylation K543 1.139 _GNEATEGSGLLLNSTGDLMK(gl)K_
ZFYVE9 Ubiquitylation K544 1.139 _GNEATEGSGLLLNSTGDLMK(gl)K_
ZFYVE9 Ubiquitylation K622 0.886 _NKNDILGKAK(gl)_


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