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Query: CDH1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDH1 0 -0.343 0.150 0.280 -0.623

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for CDH1:


Pubmed-CDH1 »
Uniprot-CDH1 »
Biogrid-CDH1 »
ProteomicsDB-CDH1 »

Tumorportal-CDH1 »
COSMIC-CDH1 »
GenomeRNAi-CDH1 »
Genecards-CDH1


Protein-protein Interactions for CDH1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDH1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CTNNA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHGC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDH1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cadherin_pro_dom IPR014868 0.78
Category members Cadherin IPR002126 0.32
Category members Cadherin_cytoplasmic-dom IPR000233 0.29
Category members Cadherin-like IPR015919 0.21


Protein complexes (CORUM database) featuring CDH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5177 Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) Database 0.31
Category members Corum 5319 CDH1-CKS1B complex Database 0.08
Category members Corum 1826 SMAD3-HEF1-APC10-CDH1 complex Database 0
Category members Corum 1834 ITGAE-ITGB7-CDH1 complex Database 0
Category members Corum 521 Polycystin-1-E-cadherin-beta-catenin complex Database 0
Category members Corum 522 Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex Database 0
Category members Corum 5281 Cell-cell junction complex (CDH1-CTNNB1) Database 0
Category members Corum 5320 CDH1-SKP2 complex Database 0


Categories featuring CDH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_292 PID_ECADHERIN_NASCENT_AJ_PATHWAY 0 2.74
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_611 PID_ECADHERIN_KERATINOCYTE_PATHWAY 0 1.34
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0005913 cell-cell adherens junction Database 1.05
Category members Pathway Pathway_295 PID_ARF6_TRAFFICKING_PATHWAY 0 0.9
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_669 PID_RAC1_PATHWAY 0 0.68
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0042493 response to drug Database 0.66
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_1026 KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 0 0.45
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_54 BIOCARTA_MTA3_PATHWAY 0 0.36
Category members GO Category GO:0070830 tight junction assembly Database 0.36
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0034329 cell junction assembly Database 0.29
Category members GO Category GO:0007156 homophilic cell adhesion Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0005912 adherens junction Database 0.25
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0045295 gamma-catenin binding Database 0.23
Category members GO Category GO:0060693 regulation of branching involved in salivary gland morphogenesis Database 0.23
Category members Pathway Pathway_581 PID_NECTIN_PATHWAY 0 0.21
Category members GO Category GO:0043220 Schmidt-Lanterman incisure Database 0.21
Category members Disease phenotype ENDOMETRIAL_CANCER ENDOMETRIAL CANCER Database 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0050680 negative regulation of epithelial cell proliferation Database 0.19
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members GO Category GO:0043296 apical junction complex Database 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members Pathway Pathway_1019 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS 0 0.17
Category members Pathway Pathway_388 KEGG_BLADDER_CANCER 0 0.16
Category members GO Category GO:0005802 trans-Golgi network Database 0.13
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0045216 cell-cell junction organization Database 0.1
Category members Pathway Pathway_626 PID_A6B1_A6B4_INTEGRIN_PATHWAY 0 0.09
Category members Disease phenotype GASTRIC_CANCER_HEREDITARY_DIFFUSE GASTRIC CANCER HEREDITARY DIFFUSE Database 0.08
Category members Pathway Pathway_1128 BIOCARTA_TGFB_PATHWAY 0 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members Disease phenotype OVARIAN_CANCER OVARIAN CANCER Database 0.01
Category members Pathway Pathway_1217 KEGG_CELL_ADHESION_MOLECULES_CAMS 0 0
Category members Pathway Pathway_1218 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL 0 0
Category members Pathway Pathway_1237 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION 0 0
Category members Pathway Pathway_1276 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_657 PID_FGF_PATHWAY 0 0
Category members Pathway Pathway_925 REACTOME_CELL_JUNCTION_ORGANIZATION 0 0
Category members Pathway Pathway_930 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 0 0
Category members Pathway Pathway_944 KEGG_THYROID_CANCER 0 0
Category members Disease phenotype Familial_gastric_cancer Familial gastric cancer Database 0
Category members GO Category GO:0001829 trophectodermal cell differentiation Database 0
Category members GO Category GO:0003382 epithelial cell morphogenesis Database 0
Category members GO Category GO:0007416 synapse assembly Database 0
Category members GO Category GO:0007605 sensory perception of sound Database 0
Category members GO Category GO:0009636 response to toxic substance Database 0
Category members GO Category GO:0009898 cytoplasmic side of plasma membrane Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0016235 aggresome Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0016342 catenin complex Database 0
Category members GO Category GO:0019538 protein metabolic process Database 0
Category members GO Category GO:0021983 pituitary gland development Database 0
Category members GO Category GO:0022408 negative regulation of cell-cell adhesion Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0030506 ankyrin binding Database 0
Category members GO Category GO:0032794 GTPase activating protein binding Database 0
Category members GO Category GO:0032880 regulation of protein localization Database 0
Category members GO Category GO:0033268 node of Ranvier Database 0
Category members GO Category GO:0033561 regulation of water loss via skin Database 0
Category members GO Category GO:0034332 adherens junction organization Database 0
Category members GO Category GO:0042993 positive regulation of transcription factor import into nucleus Database 0
Category members GO Category GO:0043219 lateral loop Database 0
Category members GO Category GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0043679 axon terminus Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0050776 regulation of immune response Database 0
Category members GO Category GO:0050839 cell adhesion molecule binding Database 0
Category members GO Category GO:0051260 protein homooligomerization Database 0
Category members GO Category GO:0060576 intestinal epithelial cell development Database 0
Category members GO Category GO:0060662 salivary gland cavitation Database 0
Category members GO Category GO:0071230 cellular response to amino acid stimulus Database 0
Category members GO Category GO:0071285 cellular response to lithium ion Database 0


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