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Query: TGFB3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TGFB3 0 -0.557 0.900 -0.540

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TGFB3 Ubiquitylation K50 -0.557 _GQILSK(gl)LR_

Background Information for TGFB3:


Pubmed-TGFB3 »
Uniprot-TGFB3 »
Biogrid-TGFB3 »
ProteomicsDB-TGFB3 »

Tumorportal-TGFB3 »
COSMIC-TGFB3 »
GenomeRNAi-TGFB3 »
Genecards-TGFB3


Protein-protein Interactions for TGFB3
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in TGFB3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cystine-knot_cytokine IPR029034 0.52
Category members TGF-b_C IPR001839 0.35
Category members TGF-b_N IPR001111 0.17
Category members TGF-beta IPR016319 0


Protein complexes (CORUM database) featuring TGFB3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3025 TGF-beta receptor II-TGF-beta3 complex Database 0.08
Category members Corum 2353 ITGAV-ITGB6-TGFB3 complex Database 0
Category members Corum 3028 TGF-beta receptor II-TGF-beta receptor I-TGF-beta3 complex Database 0


Categories featuring TGFB3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0008083 growth factor activity Database 2.34
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members Pathway Pathway_995 PID_ALK1_PATHWAY 0 0.69
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members GO Category GO:0031012 extracellular matrix Database 0.45
Category members GO Category GO:0043627 response to estrogen Database 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0060021 palate development Database 0.23
Category members GO Category GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation Database 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0007565 female pregnancy Database 0.19
Category members GO Category GO:0009986 cell surface Database 0.17
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0010718 positive regulation of epithelial to mesenchymal transition Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0030141 secretory granule Database 0.11
Category members GO Category GO:0045216 cell-cell junction organization Database 0.1
Category members GO Category GO:0032570 response to progesterone Database 0.1
Category members GO Category GO:0042476 odontogenesis Database 0.09
Category members GO Category GO:0034713 type I transforming growth factor beta receptor binding Database 0.08
Category members GO Category GO:0007184 SMAD protein import into nucleus Database 0.08
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_biventricular_form Familial isolated arrhythmogenic ventricular dysplasia biventricular form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_left_dominant_form Familial isolated arrhythmogenic ventricular dysplasia left dominant form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_right_dominant_form Familial isolated arrhythmogenic ventricular dysplasia right dominant form Database 0.05
Category members GO Category GO:0070483 detection of hypoxia Database 0.04
Category members Pathway Pathway_1128 BIOCARTA_TGFB_PATHWAY 0 0.04
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members GO Category GO:0008156 negative regulation of DNA replication Database 0.03
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1054 BIOCARTA_IL1R_PATHWAY 0 0
Category members Pathway Pathway_1124 BIOCARTA_ERYTH_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_424 KEGG_LEISHMANIA_INFECTION 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_637 BIOCARTA_CTCF_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_718 PID_GLYPICAN_1PATHWAY 0 0
Category members Pathway Pathway_723 BIOCARTA_P38MAPK_PATHWAY 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_872 BIOCARTA_ALK_PATHWAY 0 0
Category members Pathway Pathway_895 BIOCARTA_INFLAM_PATHWAY 0 0
Category members Pathway Pathway_899 BIOCARTA_NKT_PATHWAY 0 0
Category members Pathway Pathway_903 BIOCARTA_TOB1_PATHWAY 0 0
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0005114 type II transforming growth factor beta receptor binding Database 0
Category members GO Category GO:0005160 transforming growth factor beta receptor binding Database 0
Category members GO Category GO:0007435 salivary gland morphogenesis Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010936 negative regulation of macrophage cytokine production Database 0
Category members GO Category GO:0016049 cell growth Database 0
Category members GO Category GO:0022601 menstrual cycle phase Database 0
Category members GO Category GO:0030315 T-tubule Database 0
Category members GO Category GO:0030501 positive regulation of bone mineralization Database 0
Category members GO Category GO:0030879 mammary gland development Database 0
Category members GO Category GO:0031093 platelet alpha granule lumen Database 0
Category members GO Category GO:0032967 positive regulation of collagen biosynthetic process Database 0
Category members GO Category GO:0034616 response to laminar fluid shear stress Database 0
Category members GO Category GO:0040007 growth Database 0
Category members GO Category GO:0042060 wound healing Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043932 ossification involved in bone remodeling Database 0
Category members GO Category GO:0045740 positive regulation of DNA replication Database 0
Category members GO Category GO:0048286 lung alveolus development Database 0
Category members GO Category GO:0048565 digestive tract development Database 0
Category members GO Category GO:0048702 embryonic neurocranium morphogenesis Database 0
Category members GO Category GO:0048839 inner ear development Database 0
Category members GO Category GO:0050431 transforming growth factor beta binding Database 0
Category members GO Category GO:0050714 positive regulation of protein secretion Database 0
Category members GO Category GO:0051491 positive regulation of filopodium assembly Database 0
Category members GO Category GO:0051781 positive regulation of cell division Database 0
Category members GO Category GO:0060325 face morphogenesis Database 0
Category members GO Category GO:0060364 frontal suture morphogenesis Database 0
Category members GO Category GO:0060391 positive regulation of SMAD protein import into nucleus Database 0
Category members GO Category GO:0071363 cellular response to growth factor stimulus Database 0


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