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BIOCARTA_P38MAPK_PATHWAY
(Pathway_723)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
MAPK14 2 -0.160 -0.350
ATF2 2 -1.380 1.800
HMGN1 2 -0.050 0.130
HMGN1 2 -0.050 0.130
TRAF2 1 -0.570 0.540
TRAF2 1 -0.570 0.540
MAP2K4 0 -0.300 0.320
MEF2A 0 0.820 -0.530
MEF2A 0 0.820 -0.530
CDC42 0 -0.170 0.490 -0.597 -1.527 -1.013
CDC42 0 1.240 -0.940 -0.597 -1.527 -1.013
MEF2C 0 -0.980 1.550
MEF2C 0 -0.980 1.550
MAPKAPK5 0 1.100 -0.730
MAP3K1 0 0.750 -1.270
TGFB1 0 -0.550 1.050
HSPB1 0 0.710 -0.660 -0.632
TGFBR1 0 -0.260 0.020
MAP2K6 0 1.270 -0.780
RAPGEF2 0 -0.860 1.560
STAT1 0 -0.550 0.170
MEF2D 0 -0.080 -0.210
MEF2D 0 -0.080 -0.210
MEF2D 0 -0.080 -0.210
CREB1 0 1.080 -0.800 -1.027
TGFB3 0 0.900 -0.540
MAX 0 -0.780 0.530 -0.276 0.290
MAX 0 -0.780 0.530
ELK1 0
MAP3K7 0 -1.120 1.140 -1.048
RAC1 0 -0.580 1.580 0.486 -0.364 -0.568
MYC 0 0.170 0.550 -2.443 -0.949 -0.454 -1.290
RIPK1 0 -0.190 0.440
HRAS 0 1.470 -0.520
GRB2 0 -0.240 0.300 -1.021 0.057 0.906
MAP3K5 0 0.710 -0.770
DAXX 0 0.430 -1.030
DAXX 0 0.430 -1.030 -0.712 0.311

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ATF2 Phosphorylation T71 -1.263 -1.166 _NDSVIVADQTPT(ph)PTR_
ATF2 Phosphorylation S90 2.624 2.389 _NCEEVGLFNELAS(ph)PFENEFKK_
ATF2 Phosphorylation S112 1.025 1.118 _MPLDLS(ph)PLATPIIR_
CDC42 Ubiquitylation K173 -1.839 _DDPSTIEK(gl)LAK_
CDC42 Ubiquitylation K178 -0.801 -0.716 _NK(gl)QKPITPETAEK_
CDC42 Ubiquitylation K180 -1.806 _QK(gl)PITPETAEK(gl)LAR_
CDC42 Ubiquitylation K189 -1.082 _QKPITPETAEK(gl)LAR_
CDC42 Ubiquitylation K198 0.550 1.159 _AVK(gl)YVECSALTQK_
CDC42 Ubiquitylation K208 -0.937 0.038 _YVECSALTQK(gl)GLK_
CDC42 Ubiquitylation K228 -2.488 _NVFDEAILAALEPPEPK(gl)K_
CDC42 Ubiquitylation K229 -1.254 _NVFDEAILAALEPPEPKK(gl)_
CREB1 Phosphorylation S271 -0.979 -1.450 _TAPTSTIAPGVVM(ox)ASS(ph)PALPTQPAEEAAR_
CREB1 Ubiquitylation K333 1.343 _ALK(gl)DLYCHK_
DAXX Phosphorylation S33 -2.344 -2.634 _(ac)ATANSIIVLDDDDEDEAAAQPGPSHPLPNAAS(ph)PGAEAPSSSEPHGAR_
DAXX Phosphorylation S178 -1.839 -1.808 _KLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQS(ph)PR_
DAXX Ubiquitylation K255 1.051 -0.046 _LCELK(gl)DCSSLTGR_
DAXX Ubiquitylation K289 -0.127 _LINK(gl)PGPDTFPDYGDVLR_
DAXX Ubiquitylation K390 0.502 _LDEVISK(gl)YAMLQDK_
DAXX Phosphorylation S495 0.727 0.865 _DGDKS(ph)PMSSLQISNEK_
DAXX Phosphorylation S671 -0.877 -1.038 _ICTLPSPPS(ph)PLASLAPVADSSTR_
DAXX Phosphorylation S675 -0.654 _KICTLPSPPSPLAS(ph)LAPVADSSTR_
DAXX Phosphorylation S688 -0.111 -0.664 _VDS(ph)PSHGLVTSSLCIPSPAR_
DAXX Phosphorylation S690 -0.048 _VDS(ph)PSHGLVTSSLCIPSPAR_
DAXX Phosphorylation S702 -0.432 -0.620 _VDSPSHGLVTSSLCIPS(ph)PAR_
ELK1 Phosphorylation S273 -0.601 -0.553 _PAVVLPSAAPAGAAAPPS(ph)GSR_
ELK1 Phosphorylation S275 -0.601 -0.553 _PAVVLPSAAPAGAAAPPS(ph)GSR_
ELK1 Phosphorylation S403 0.568 -0.579 _DLELPLS(ph)PSLLGGPGPER_
GRB2 Ubiquitylation K10 0.146 _YDFK(gl)ATADDELSFK_
GRB2 Ubiquitylation K20 -0.078 _ATADDELSFK(gl)R_
GRB2 Ubiquitylation K69 -0.362 0.641 _AK(gl)AEEMLSK_
GRB2 Ubiquitylation K76 0.754 _AEEMLSK(gl)QR_
GRB2 Ubiquitylation K109 0.381 -0.002 _FGNDVQHFK(gl)VLR_
HMGN1 Phosphorylation S7 1.696 0.085 _KVS(ph)SAEGAAKEEPK_
HMGN1 Phosphorylation S8 0.243 0.475 _VSS(ph)AEGAAKEEPK_
HMGN1 Ubiquitylation K30 1.557 _VSSAEGAAK(gl)EEPK_
HMGN1 Phosphorylation S86 0.276 0.310 _TEES(ph)PASDEAGEKEAK_
HMGN1 Phosphorylation S89 0.009 _TEESPAS(ph)DEAGEKEAK_
HMGN1 Phosphorylation S99 0.293 0.342 _TEESPASDEAGEKEAKS(ph)D_
HRAS Ubiquitylation K170 -1.005 _K(gl)LNPPDESGPGCMSCK_
HSPB1 Phosphorylation S82 1.036 0.723 _QLS(ph)SGVSEIR_
HSPB1 Ubiquitylation K198 -1.654 _AQLGGPEAAK(gl)SDETAAK_
MAP2K4 Phosphorylation S80 0.441 _LRTHS(ph)IESSGK_
MAP2K6 Phosphorylation T28 -1.813 -0.792 _EAFEQPQTSST(ph)PPRDLDSK_
MAP2K6 Ubiquitylation K232 0.220 _INPELNQK(gl)GYSVK_
MAP3K1 Phosphorylation S292 0.209 _RAPS(ph)PDGFSPYSPEETNR_
MAP3K1 Phosphorylation S506 1.427 _SHDFYSHELS(ph)SPVDSPSSLR_
MAP3K1 Phosphorylation S507 1.436 _SHDFYSHELSS(ph)PVDSPSSLR_
MAP3K1 Phosphorylation S923 0.127 -0.120 _LSAS(ph)SEDISER_
MAP3K5 Phosphorylation S1066 -1.241 _SISLPVPVLVEDTSSSSEYGSVS(ph)PDTELKVDPFSFK_
MAP3K5 Phosphorylation S1113 -1.408 -0.562 _TLFLGIPDENFEDHSAPPS(ph)PEEK_
MAP3K7 Phosphorylation S374 0.149 -0.337 _GS(ph)SVESLPPTSEGK_
MAP3K7 Phosphorylation S375 0.171 -0.087 _GSS(ph)VESLPPTSEGK_
MAP3K7 Phosphorylation S389 1.072 1.445 _RMS(ph)ADMSEIEAR_
MAP3K7 Phosphorylation S439 0.246 0.198 _S(ph)IQDLTVTGTEPGQVSSR_
MAP3K7 Ubiquitylation K474 -0.385 -0.242 _MITTSGPTSEK(gl)PTR_
MAP3K7 Ubiquitylation K589 -0.104 _SLSTYYQQCK(gl)K_
MAP3K7 Ubiquitylation K590 -0.551 0.560 _K(gl)QLEVIR_
MAPK14 Phosphorylation S2 3.221 3.623 _(ac)S(ph)QERPTFYR_
MAPK14 Phosphorylation T180 0.958 1.087 _HTDDEM(ox)T(ph)GYVATR_
MAPK14 Phosphorylation Y182 1.388 1.374 _HTDDEM(ox)TGY(ph)VATR_
MAPK14 Ubiquitylation K249 0.073 -1.380 _LVGTPGAELLKK(gl)_
MAPKAPK5 Phosphorylation T182 -0.559 -0.706 _IDQGDLM(ox)T(ph)PQFTPYYVAPQVLEAQR_
MAX Phosphorylation S2 0.341 -0.060 _(ac)S(ph)DNDDIEVES(ph)DEEQPR_
MAX Phosphorylation S2 0.510 0.568 _(ac)S(ph)DNDDIEVESDADKR_
MAX Phosphorylation S11 0.341 -0.060 _(ac)S(ph)DNDDIEVES(ph)DEEQPR_
MAX Phosphorylation S11 -0.408 0.069 _(ac)S(ph)DNDDIEVES(ph)DADKR_
MAX Ubiquitylation K57 -0.903 0.246 _DSVPSLQGEK(gl)ASR_
MEF2A Ubiquitylation K23 -0.140 _QVTFTK(gl)R_
MEF2A Phosphorylation S235 0.664 -0.092 _AS(ph)PNLIGATGANSLGK_
MEF2A Phosphorylation T253 -1.271 _VMPT(ph)KSPPPPGGGNLGMNSR_
MEF2A Phosphorylation S255 -1.235 _VMPTKS(ph)PPPPGGGNLGMNSR_
MEF2A Phosphorylation S408 -0.173 -0.049 _SEPIS(ph)PPRDR_
MEF2A Phosphorylation S494 -0.858 -1.232 _GDFHSPIVLGRPPNTEDRES(ph)PSVK_
MEF2C Ubiquitylation K23 -0.140 _QVTFTK(gl)R_
MEF2C Phosphorylation S240 0.008 0.302 _NS(ph)PGLLVSPGNLNK_
MEF2C Phosphorylation S406 0.272 0.338 _SEPVS(ph)PPRDR_
MEF2D Ubiquitylation K23 -0.140 _QVTFTK(gl)R_
MEF2D Phosphorylation S184 -1.118 -1.050 _VIPAKS(ph)PPPPTHSTQLGAPSR_
MEF2D Phosphorylation S185 0.259 -0.467 _LLS(ph)PQQPALQR_
MEF2D Phosphorylation S377 0.418 0.181 _SEPVS(ph)PSRER_
MYC Phosphorylation S20 -1.444 -1.145 _PLNVS(ph)FTNR_
MYC Phosphorylation T72 -1.699 -1.813 _FELLPT(ph)PPLS(ph)PSRR_
MYC Phosphorylation S76 -1.777 -1.435 _FELLPTPPLS(ph)PSR_
MYC Phosphorylation S81 0.459 _S(ph)GLCSPSYVAVTPFSLR_
MYC Phosphorylation S85 0.199 0.073 _SGLCS(ph)PSYVAVTPFSLR_
MYC Ubiquitylation K162 -2.475 -1.259 _LVSEK(gl)LASYQAAR_
MYC Phosphorylation S295 -0.903 _SESGS(ph)PSAGGHSKPPHSPLVLK_
MYC Phosphorylation S307 -1.486 _SES(ph)GSPSAGGHSKPPHS(ph)PLVLK_
MYC Ubiquitylation K340 -2.449 _VK(gl)LDSVR_
MYC Ubiquitylation K403 -3.432 _DQIPELENNEK(gl)APK_
RAC1 Ubiquitylation K115 -1.745 -0.215 _AK(gl)WYPEVR_
RAC1 Ubiquitylation K142 0.492 _LDLRDDK(gl)DTIEK_
RAC1 Ubiquitylation K152 0.099 -0.292 _K(gl)LTPITYPQGLAMAK_
RAC1 Ubiquitylation K166 -0.981 -0.655 _LTPITYPQGLAMAK(gl)EIGAVK_
RAC1 Ubiquitylation K172 1.026 0.412 _EIGAVK(gl)YLECSALTQR_
RAC1 Ubiquitylation K185 -0.113 0.578 _GLK(gl)TVFDEAIR_
RAC1 Ubiquitylation K202 -1.379 -1.447 _AVLCPPPVK(gl)KR_
RAC1 Ubiquitylation K203 -1.708 -1.447 _AVLCPPPVKK(gl)_
RAPGEF2 Phosphorylation S1022 0.043 -0.570 _SETS(ph)PVAPR_
RAPGEF2 Phosphorylation S1080 -0.612 _DLPPFGINS(ph)PQALK_
RIPK1 Ubiquitylation K642 -0.431 _EGIK(gl)GATVGK_
STAT1 Phosphorylation S727 1.377 0.974 _LQTTDNLLPMS(ph)PEEFDEVSR_
TGFB1 Ubiquitylation K50 -0.557 _GQILSK(gl)LR_
TGFB3 Ubiquitylation K50 -0.557 _GQILSK(gl)LR_
TGFBR1 Ubiquitylation K449 -0.991 _VVCEQK(gl)LRPNIPNR_
TGFBR1 Ubiquitylation K502 0.553 0.430 _TLSQLSQQEGIK(gl)M_
TRAF2 Phosphorylation T7 -0.822 -1.190 _(ac)AAASVT(ph)PPGSLELLQPGFSK_
TRAF2 Ubiquitylation K27 -0.253 2.194 _TLLGTK(gl)LEAK_
TRAF2 Ubiquitylation K119 0.519 _GTLK(gl)EYESCHEGR_
TRAF2 Ubiquitylation K176 -1.233 1.022 _APCCGADVK(gl)AHHEVCPK_
TRAF2 Ubiquitylation K207 0.147 0.918 _FQDHVK(gl)TCGK_
TRAF2 Ubiquitylation K481 -0.507 0.417 _MEAK(gl)NSYVR_


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