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Query: MAX

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MAX 0 0.965 -0.780 0.530
MAX 0 0.965 -0.780 0.530 -0.276 0.290

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MAX Phosphorylation S2 0.510 0.568 _(ac)S(ph)DNDDIEVESDADKR_
MAX Ubiquitylation K57 -0.903 0.246 _DSVPSLQGEK(gl)ASR_
MAX Phosphorylation S11 -0.408 0.069 _(ac)S(ph)DNDDIEVES(ph)DADKR_
MAX Phosphorylation S2 0.341 -0.060 _(ac)S(ph)DNDDIEVES(ph)DEEQPR_
MAX Phosphorylation S11 0.341 -0.060 _(ac)S(ph)DNDDIEVES(ph)DEEQPR_

Background Information for MAX:


Pubmed-MAX »
Uniprot-MAX »
Biogrid-MAX »
ProteomicsDB-MAX »

Tumorportal-MAX »
COSMIC-MAX »
GenomeRNAi-MAX »
Genecards-MAX


Protein-protein Interactions for MAX
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait JARID1C;KDM5C Cat. description Hein, Mann, Cell 2015
Category members IP bait MAX Cat. description Hein, Mann, Cell 2015
Category members IP bait MYC Cat. description Hein, Mann, Cell 2015
Category members IP bait BFSP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MXD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MXD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MAX
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members bHLH_dom IPR011598 0.32


Protein complexes (CORUM database) featuring MAX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2653 MYC-MAX-BLOC1S1 complex Database 0


Categories featuring MAX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0016605 PML body Database 1.41
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_835 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 0 0.63
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0071339 MLL1 complex Database 0.45
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members GO Category GO:0003712 transcription cofactor activity Database 0.21
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_858 PID_MYC_PATHWAY 0 0.17
Category members GO Category GO:0009267 cellular response to starvation Database 0.03
Category members GO Category GO:0010243 response to organonitrogen compound Database 0.02
Category members GO Category GO:0048678 response to axon injury Database 0.01
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_723 BIOCARTA_P38MAPK_PATHWAY 0 0
Category members Disease phenotype Hereditary_pheochromocytoma-paraganglioma Hereditary pheochromocytoma-paraganglioma Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0032868 response to insulin Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0060041 retina development in camera-type eye Database 0
Category members GO Category GO:0071375 cellular response to peptide hormone stimulus Database 0


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