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Query: STAT1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
STAT1 0 2.521 -0.550 0.170

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
STAT1 Phosphorylation S727 1.377 0.974 _LQTTDNLLPMS(ph)PEEFDEVSR_

Background Information for STAT1:


Pubmed-STAT1 »
Uniprot-STAT1 »
Biogrid-STAT1 »
ProteomicsDB-STAT1 »

Tumorportal-STAT1 »
COSMIC-STAT1 »
GenomeRNAi-STAT1 »
Genecards-STAT1


Protein-protein Interactions for STAT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait STAT1 Cat. description Hein, Mann, Cell 2015


Protein Domains in STAT1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH2 IPR000980 0.05
Category members STAT_TF_prot_interaction IPR013799 0.03
Category members STAT_TF_alpha IPR013800 0.03
Category members STAT_TF_DNA-bd IPR013801 0.03
Category members p53-like_TF_DNA-bd IPR008967 0
Category members STAT_TF_coiled-coil IPR015988 0


Protein complexes (CORUM database) featuring STAT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5573 Stat1-alpha-dimer-CBP DNA-protein complex Database 0
Category members Corum 60 Interferon-stimulated gene factor 3 transcription complex ISGF3 Database 0


Categories featuring STAT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_559 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS 0 1.1
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_592 REACTOME_SIGNALING_BY_FGFR1_MUTANTS 0 0.4
Category members Pathway Pathway_528 REACTOME_SIGNALING_BY_FGFR_MUTANTS 0 0.37
Category members GO Category GO:0032496 response to lipopolysaccharide Database 0.35
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_964 BIOCARTA_CHEMICAL_PATHWAY 0 0.24
Category members GO Category GO:0048661 positive regulation of smooth muscle cell proliferation Database 0.24
Category members GO Category GO:0009612 response to mechanical stimulus Database 0.23
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0042542 response to hydrogen peroxide Database 0.19
Category members Pathway Pathway_534 BIOCARTA_GLEEVEC_PATHWAY 0 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_427 PID_IL23_PATHWAY 0 0.17
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_546 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 0 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members Pathway Pathway_537 PID_IFNG_PATHWAY 0 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Pathway Pathway_601 PID_IL2_1PATHWAY 0 0.1
Category members Pathway Pathway_578 BIOCARTA_EGF_PATHWAY 0 0.09
Category members Pathway Pathway_584 BIOCARTA_TPO_PATHWAY 0 0.08
Category members GO Category GO:0005164 tumor necrosis factor receptor binding Database 0.08
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0060334 regulation of interferon-gamma-mediated signaling pathway Database 0.07
Category members GO Category GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding Database 0.05
Category members GO Category GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway Database 0.04
Category members GO Category GO:0031730 CCR5 chemokine receptor binding Database 0.04
Category members Pathway Pathway_630 BIOCARTA_PDGF_PATHWAY 0 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_906 REACTOME_REGULATION_OF_IFNG_SIGNALING 0 0.01
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1134 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING 0 0
Category members Pathway Pathway_1170 REACTOME_IL_6_SIGNALING 0 0
Category members Pathway Pathway_1181 BIOCARTA_IL22BP_PATHWAY 0 0
Category members Pathway Pathway_1224 REACTOME_REGULATION_OF_IFNA_SIGNALING 0 0
Category members Pathway Pathway_1225 ST_TYPE_I_INTERFERON_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_423 PID_IL12_2PATHWAY 0 0
Category members Pathway Pathway_424 KEGG_LEISHMANIA_INFECTION 0 0
Category members Pathway Pathway_432 PID_SHP2_PATHWAY 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_522 PID_KIT_PATHWAY 0 0
Category members Pathway Pathway_569 PID_GMCSF_PATHWAY 0 0
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_612 KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_652 PID_IL6_7_PATHWAY 0 0
Category members Pathway Pathway_657 PID_FGF_PATHWAY 0 0
Category members Pathway Pathway_703 PID_EPO_PATHWAY 0 0
Category members Pathway Pathway_704 BIOCARTA_BIOPEPTIDES_PATHWAY 0 0
Category members Pathway Pathway_719 ST_INTERFERON_GAMMA_PATHWAY 0 0
Category members Pathway Pathway_723 BIOCARTA_P38MAPK_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Pathway Pathway_749 BIOCARTA_IL10_PATHWAY 0 0
Category members Pathway Pathway_898 REACTOME_INTERFERON_GAMMA_SIGNALING 0 0
Category members Pathway Pathway_909 PID_IL27_PATHWAY 0 0
Category members Pathway Pathway_913 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING 0 0
Category members Disease phenotype ATYPICAL_MYCOBACTERIOSIS_FAMILIAL ATYPICAL MYCOBACTERIOSIS FAMILIAL Database 0
Category members Disease phenotype Chronic_mucocutaneous_candidosis Chronic mucocutaneous candidosis Database 0
Category members GO Category GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0001937 negative regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0002053 positive regulation of mesenchymal cell proliferation Database 0
Category members GO Category GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007259 JAK-STAT cascade Database 0
Category members GO Category GO:0007584 response to nutrient Database 0
Category members GO Category GO:0008015 blood circulation Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009617 response to bacterium Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0016525 negative regulation of angiogenesis Database 0
Category members GO Category GO:0031663 lipopolysaccharide-mediated signaling pathway Database 0
Category members GO Category GO:0033209 tumor necrosis factor-mediated signaling pathway Database 0
Category members GO Category GO:0034097 response to cytokine Database 0
Category members GO Category GO:0035458 cellular response to interferon-beta Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0043330 response to exogenous dsRNA Database 0
Category members GO Category GO:0043434 response to peptide hormone Database 0
Category members GO Category GO:0051591 response to cAMP Database 0
Category members GO Category GO:0060333 interferon-gamma-mediated signaling pathway Database 0
Category members GO Category GO:0060337 type I interferon signaling pathway Database 0
Category members GO Category GO:0060338 regulation of type I interferon-mediated signaling pathway Database 0


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