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negative regulation of I-kappaB kinase/NF-kappaB signaling
(GO:0043124)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
CASP8 1 1.120 -1.090
RHOA 0 -0.510 1.370 -0.485 0.532 0.279
GSTP1 0 -1.460 2.360 0.731 -2.952
SIRT1 0 0.910 -0.910
PPM1A 0 -0.680 1.340 0.402
PPM1A 0 -0.680 1.340 -1.556 -0.874
DNAJA3 0 -0.010 -0.240 0.786 0.226 -0.161 -0.800 -0.347
STAT1 0 -0.550 0.170
TNFAIP3 0 0.760 -0.500
RIPK1 0 -0.190 0.440
PPM1B 0 -0.180 0.420 -0.429 0.307
PPM1B 0 -0.180 0.420 0.248
TNIP1 0 1.510 -0.910
TNIP1 0 1.510 -0.910
NLRX1 0 -0.720 0.810 -0.012
OTUD7B 0
TLE1 0 0.270 0.000 0.116

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
CASP8 Ubiquitylation K183 1.917 _IINDYEEFSK(gl)ER_
CASP8 Ubiquitylation K461 -2.031 _NMGK(gl)QMPQPTFTLR_
OTUD7B Ubiquitylation K93 0.152 0.969 _QDDIVQEK(gl)R_
OTUD7B Phosphorylation S100 0.815 0.868 _GIS(ph)HASSSIVSLAR_
OTUD7B Phosphorylation S449 -0.896 _WIPLSSDAQAPLAQPES(ph)PTASAGDEPR_
OTUD7B Ubiquitylation K644 0.103 0.509 _FLAEQK(gl)QK_
PPM1A Ubiquitylation K278 -0.176 _VCNEVVDTCLYK(gl)GSR_
PPM1B Ubiquitylation K90 -0.117 _AAGK(gl)SGSALELSVENVK_
RHOA Ubiquitylation K6 0.708 _K(gl)KLVIVGDGACGK_
RHOA Ubiquitylation K7 0.708 _K(gl)KLVIVGDGACGK_
RHOA Ubiquitylation K118 -0.408 _HFCPNVPIILVGNK(gl)K_
RHOA Ubiquitylation K119 -0.408 _HFCPNVPIILVGNK(gl)K_
RHOA Ubiquitylation K135 -0.528 -0.796 _MK(gl)QEPVKPEEGRDMANR_
RHOA Ubiquitylation K162 0.345 0.453 _IGAFGYMECSAK(gl)TK_
RIPK1 Ubiquitylation K642 -0.431 _EGIK(gl)GATVGK_
SIRT1 Phosphorylation S14 -0.369 -0.246 _(ac)ADEAALALQPGGS(ph)PSAAGADR_
SIRT1 Phosphorylation S16 -0.306 -1.665 _(ac)ADEAALALQPGGS(ph)PS(ph)AAGADREAASSPAGEPLR_
SIRT1 Phosphorylation S26 -1.047 -0.245 _EAAS(ph)SPAGEPLR_
SIRT1 Phosphorylation S27 0.351 -0.363 _EAASS(ph)PAGEPLR_
SIRT1 Phosphorylation S47 -0.574 -0.607 _S(ph)PGEPGGAAPER_
SIRT1 Ubiquitylation K238 -1.641 _RK(gl)DINTIEDAVK_
SIRT1 Ubiquitylation K499 -2.138 -0.204 _LGGEYAK(gl)LCCNPVK_
SIRT1 Ubiquitylation K578 -2.782 _GCMEEK(gl)PQEVQTSR_
SIRT1 Ubiquitylation K601 -3.051 _NVESIAEQMENPDLK(gl)NVGSSTGEK_
STAT1 Phosphorylation S727 1.377 0.974 _LQTTDNLLPMS(ph)PEEFDEVSR_
TLE1 Phosphorylation S286 0.242 0.160 _DASSS(ph)PASTASSASSTSLK_
TNFAIP3 Ubiquitylation K722 0.496 0.176 _ASCK(gl)NILACR_
TNIP1 Phosphorylation S77 -0.684 _DNELLPPPS(ph)PSLGSFDPLAELTGK_
TNIP1 Ubiquitylation K371 -0.625 _LLLAK(gl)SK_
TNIP1 Ubiquitylation K373 -0.353 _LLLAKSK(gl)_
TNIP1 Phosphorylation S403 0.455 0.424 _YLQDQLS(ph)PLTR_


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