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Query: PPM1A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PPM1A 0 -0.864 -0.680 1.340 -1.556 -0.874
PPM1A 0 -0.864 -0.680 1.340 0.402

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PPM1A Ubiquitylation K278 -0.176 _VCNEVVDTCLYK(gl)GSR_

Background Information for PPM1A:


Pubmed-PPM1A »
Uniprot-PPM1A »
Biogrid-PPM1A »
ProteomicsDB-PPM1A »

Tumorportal-PPM1A »
COSMIC-PPM1A »
GenomeRNAi-PPM1A »
Genecards-PPM1A


Protein-protein Interactions for PPM1A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTR5 Cat. description Hein, Mann, Cell 2015
Category members IP bait CSNK1D Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPD Cat. description Hein, Mann, Cell 2015
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PIGS Cat. description Hein, Mann, Cell 2015
Category members IP bait TECPR2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TOR1AIP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADAMTS12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ALDH3B1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCL22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CER1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CERKL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHST10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXL14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GDF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIP1R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INSL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MTERFD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPM1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRSS22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNASE13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TECPR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2CBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZDHHC11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PPM1A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PP2C-like_dom IPR001932 0.04
Category members PP2C_C IPR012911 0


Protein complexes (CORUM database) featuring PPM1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PPM1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members Pathway Pathway_1149 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 0 0.19
Category members Pathway Pathway_802 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 0 0.17
Category members GO Category GO:0004722 protein serine/threonine phosphatase activity Database 0.11
Category members GO Category GO:0004721 phosphoprotein phosphatase activity Database 0.11
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members Pathway Pathway_823 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY 0 0.07
Category members Pathway Pathway_1131 PID_SMAD2_3PATHWAY 0 0.04
Category members Pathway Pathway_1150 REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK 0 0.04
Category members GO Category GO:0042347 negative regulation of NF-kappaB import into nucleus Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members GO Category GO:0033192 calmodulin-dependent protein phosphatase activity Database 0.01
Category members Pathway Pathway_1133 PID_BMP_PATHWAY 0 0
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_302 REACTOME_PKB_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005891 voltage-gated calcium channel complex Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0006499 N-terminal protein myristoylation Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0010991 negative regulation of SMAD protein complex assembly Database 0
Category members GO Category GO:0016311 dephosphorylation Database 0
Category members GO Category GO:0030145 manganese ion binding Database 0
Category members GO Category GO:0030177 positive regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0035970 peptidyl-threonine dephosphorylation Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0070412 R-SMAD binding Database 0


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