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bioLOGIC Data

Query: PPM1B

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
PPM1B	0	0.429	-0.180	0.420		-0.429	0.307
PPM1B	0	0.429	-0.180	0.420	0.248

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
PPM1B	Ubiquitylation	K90	-0.117		_AAGK(gl)SGSALELSVENVK_

Background Information for PPM1B:

Pubmed-PPM1B »

Uniprot-PPM1B »

Biogrid-PPM1B »

ProteomicsDB-PPM1B »

Tumorportal-PPM1B »

COSMIC-PPM1B »

GenomeRNAi-PPM1B »

Genecards-PPM1B

Protein-protein Interactions for PPM1B

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait C1orf87	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait CERKL	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait FAM63B	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait HIP1R	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait NR1I3	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PPM1A	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PPM1B	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PVR	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in PPM1B

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	PP2C-like_dom	IPR001932	0.04
Category members	PP2C_C	IPR012911	0

Protein complexes (CORUM database) featuring PPM1B

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)

Categories featuring PPM1B

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005829	cytosol	Database	INF
Category members	Pathway	Pathway_689	REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES	0	3.51
Category members	Pathway	Pathway_458	REACTOME_IMMUNE_SYSTEM	0	3
Category members	Pathway	Pathway_699	REACTOME_INTERFERON_SIGNALING	0	0.86
Category members	GO Category	GO:0016020	membrane	Database	0.52
Category members	GO Category	GO:0019221	cytokine-mediated signaling pathway	Database	0.44
Category members	Pathway	Pathway_505	REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM	0	0.33
Category members	Disease phenotype	2p21_microdeletion_syndrome	2p21 microdeletion syndrome	Database	0.23
Category members	GO Category	GO:0004722	protein serine/threonine phosphatase activity	Database	0.11
Category members	GO Category	GO:0004721	phosphoprotein phosphatase activity	Database	0.11
Category members	GO Category	GO:0003824	catalytic activity	Database	0.11
Category members	GO Category	GO:0042347	negative regulation of NF-kappaB import into nucleus	Database	0.04
Category members	GO Category	GO:0050687	negative regulation of defense response to virus	Database	0.03
Category members	Pathway	Pathway_715	KEGG_MAPK_SIGNALING_PATHWAY	0	0
Category members	GO Category	GO:0000287	magnesium ion binding	Database	0
Category members	GO Category	GO:0006470	protein dephosphorylation	Database	0
Category members	GO Category	GO:0006499	N-terminal protein myristoylation	Database	0
Category members	GO Category	GO:0030145	manganese ion binding	Database	0
Category members	GO Category	GO:0032688	negative regulation of interferon-beta production	Database	0
Category members	GO Category	GO:0035970	peptidyl-threonine dephosphorylation	Database	0
Category members	GO Category	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	Database	0