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Query: TLE1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TLE1 0 0.518 0.270 0.000 0.116

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TLE1 Phosphorylation S286 0.242 0.160 _DASSS(ph)PASTASSASSTSLK_

Background Information for TLE1:


Pubmed-TLE1 »
Uniprot-TLE1 »
Biogrid-TLE1 »
ProteomicsDB-TLE1 »

Tumorportal-TLE1 »
COSMIC-TLE1 »
GenomeRNAi-TLE1 »
Genecards-TLE1


Protein-protein Interactions for TLE1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HLX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RIPPLY1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RIPPLY2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBX20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TLE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TLE4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNNI2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VENTX Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TLE1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members Groucho/TLE_N IPR005617 0
Category members Groucho_enhance IPR009146 0


Protein complexes (CORUM database) featuring TLE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3135 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.58
Category members Corum 1729 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.02
Category members Corum 3120 OCT1-OBF1-DNA-TLE1 complex Database 0
Category members Corum 3124 TLE1-TLE2 complex Database 0
Category members Corum 3164 HESX1-TLE1 complex Database 0


Categories featuring TLE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members Pathway Pathway_824 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION 0 0.14
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members Pathway Pathway_941 BIOCARTA_WNT_PATHWAY 0 0.08
Category members GO Category GO:0001106 RNA polymerase II transcription corepressor activity Database 0.06
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0030178 negative regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling Database 0


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