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Query: CASP8

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CASP8 1 -0.114 1.120 -1.090

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CASP8 Ubiquitylation K461 -2.031 _NMGK(gl)QMPQPTFTLR_
CASP8 Ubiquitylation K183 1.917 _IINDYEEFSK(gl)ER_

Background Information for CASP8:


Pubmed-CASP8 »
Uniprot-CASP8 »
Biogrid-CASP8 »
ProteomicsDB-CASP8 »

Tumorportal-CASP8 »
COSMIC-CASP8 »
GenomeRNAi-CASP8 »
Genecards-CASP8


Protein-protein Interactions for CASP8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BLM Cat. description Hein, Mann, Cell 2015
Category members IP bait GMNN Cat. description Hein, Mann, Cell 2015
Category members IP bait MLKL Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R1A Cat. description Hein, Mann, Cell 2015
Category members IP bait VANGL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CFLAR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF10A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF10B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CASP8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DEATH-like_dom IPR011029 1.15
Category members Pept_C14_ICE_p20 IPR001309 0.07
Category members Pept_C14_caspase IPR011600 0.07
Category members Pept_C14A_p45_core IPR015917 0.04
Category members DED IPR001875 0
Category members Pept_C14_p10 IPR002138 0


Protein complexes (CORUM database) featuring CASP8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1062 BAR-BCL2-CASP8 complex Database 0
Category members Corum 2054 CASP8-FADD-MALT1-BCL10 complex Database 0
Category members Corum 2055 CASP8-CHUK-IKBKB-MALT1-BCL10 complex Database 0
Category members Corum 2056 BCL10-CHUK-BCL10-IKBKB complex Database 0
Category members Corum 5473 FAS-FADD-CASP8 complex Database 0
Category members Corum 5749 MRIT complex Database 0
Category members Corum 5798 Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced Database 0
Category members Corum 5799 Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced Database 0
Category members Corum 5800 Death-inducing signaling complex DISC (type I cells associated), stimulated Database 0
Category members Corum 5859 FAS-FADD-CASP8-CASP10 complex Database 0
Category members Corum 5860 FAS-FADD-CASP8 complex Database 0
Category members Corum 5991 LRRK2-FADD-CASP8 Database 0


Categories featuring CASP8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_962 BIOCARTA_FAS_PATHWAY 0 1.75
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members Pathway Pathway_963 BIOCARTA_TNFR1_PATHWAY 0 0.44
Category members GO Category GO:0004197 cysteine-type endopeptidase activity Database 0.38
Category members GO Category GO:0032496 response to lipopolysaccharide Database 0.35
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members Pathway Pathway_1053 KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members GO Category GO:0034612 response to tumor necrosis factor Database 0.21
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members GO Category GO:0070243 regulation of thymocyte apoptotic process Database 0.18
Category members Pathway Pathway_596 PID_TRAIL_PATHWAY 0 0.17
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members Pathway Pathway_1082 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS 0 0.16
Category members Pathway Pathway_1015 PID_HIV_NEF_PATHWAY 0 0.15
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members Disease phenotype LUNG_CANCER LUNG CANCER Database 0.12
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members Pathway Pathway_1018 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS 0 0.11
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members GO Category GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway Database 0.09
Category members GO Category GO:0005164 tumor necrosis factor receptor binding Database 0.08
Category members GO Category GO:0046677 response to antibiotic Database 0.08
Category members GO Category GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process Database 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members Pathway Pathway_484 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 0 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_1056 REACTOME_NOD1_2_SIGNALING_PATHWAY 0 0.04
Category members Pathway Pathway_1162 BIOCARTA_SODD_PATHWAY 0 0.04
Category members Pathway Pathway_521 PID_AVB3_INTEGRIN_PATHWAY 0 0.03
Category members GO Category GO:0042110 T cell activation Database 0.02
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members Pathway Pathway_965 BIOCARTA_CASPASE_PATHWAY 0 0.01
Category members Pathway Pathway_1012 BIOCARTA_MITOCHONDRIA_PATHWAY 0 0
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1020 BIOCARTA_DEATH_PATHWAY 0 0
Category members Pathway Pathway_1021 ST_TUMOR_NECROSIS_FACTOR_PATHWAY 0 0
Category members Pathway Pathway_1042 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_307 SA_FAS_SIGNALING 0 0
Category members Pathway Pathway_483 KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_612 KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_650 PID_FAS_PATHWAY 0 0
Category members Pathway Pathway_734 PID_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_737 BIOCARTA_CERAMIDE_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Pathway Pathway_959 SA_CASPASE_CASCADE 0 0
Category members Pathway Pathway_966 BIOCARTA_D4GDI_PATHWAY 0 0
Category members Pathway Pathway_990 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS 0 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001841 neural tube formation Database 0
Category members GO Category GO:0002020 protease binding Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0008234 cysteine-type peptidase activity Database 0
Category members GO Category GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors Database 0
Category members GO Category GO:0009409 response to cold Database 0
Category members GO Category GO:0030101 natural killer cell activation Database 0
Category members GO Category GO:0030225 macrophage differentiation Database 0
Category members GO Category GO:0031264 death-inducing signaling complex Database 0
Category members GO Category GO:0031265 CD95 death-inducing signaling complex Database 0
Category members GO Category GO:0032025 response to cobalt ion Database 0
Category members GO Category GO:0032355 response to estradiol Database 0
Category members GO Category GO:0042113 B cell activation Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0044297 cell body Database 0
Category members GO Category GO:0045651 positive regulation of macrophage differentiation Database 0
Category members GO Category GO:0045862 positive regulation of proteolysis Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0
Category members GO Category GO:0051603 proteolysis involved in cellular protein catabolic process Database 0
Category members GO Category GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development Database 0
Category members GO Category GO:0071260 cellular response to mechanical stimulus Database 0
Category members GO Category GO:0071407 cellular response to organic cyclic compound Database 0


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