Results for the Category
REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10
(Pathway_1042)
| RNAi screen result | RNAPII IP (MG132) | CSB IP | CSB IP (MG132) | Chrom. | Chrom. (MG132) | Ubi /Phospo | Ubi /Phospho (MG132) |
| W | |||||||
| Gene name | MGoogle Score | RNAi high | RNAi low | RNAPII-IP (MG132) | CSB-IP | CSB-IP (MG132) | Chrom. | Chrom. (MG132) |
|---|---|---|---|---|---|---|---|---|
| CASP8 | 1 | 1.120 | -1.090 | |||||
| TRIM25 | 1 | -0.120 | -0.240 | 0.224 | -1.159 | |||
| MAVS | 0 | 1.610 | -0.380 | -1.056 | -0.630 | |||
| IKBKB | 0 | 0.400 | 0.610 | |||||
| IFIH1 | 0 | 1.630 | -0.790 | |||||
| RIPK1 | 0 | -0.190 | 0.440 | |||||
| CHUK | 0 | -0.480 |
| Gene name | PTM type | PTM site | UV | UV (MG132) | Sequence |
|---|---|---|---|---|---|
| CASP8 | Ubiquitylation | K183 | 1.917 | _IINDYEEFSK(gl)ER_ | |
| CASP8 | Ubiquitylation | K461 | -2.031 | _NMGK(gl)QMPQPTFTLR_ | |
| CHUK | Ubiquitylation | K296 | -1.637 | _GGPVDLTLK(gl)QPR_ | |
| IFIH1 | Phosphorylation | S301 | -1.067 | _AS(ph)PEPELQLRPYQMEVAQPALEGK_ | |
| IKBKB | Ubiquitylation | K106 | 0.253 | _K(gl)YLNQFENCCGLR_ | |
| IKBKB | Phosphorylation | S672 | 0.670 | 0.244 | _GPVSGS(ph)PDSMNASR_ |
| MAVS | Phosphorylation | S152 | 0.146 | -0.466 | _EKEPSYPMPVQETQAPES(ph)PGENSEQALQTLSPR_ |
| MAVS | Phosphorylation | S165 | -0.888 | _EKEPSYPMPVQETQAPESPGENSEQALQTLS(ph)PR_ | |
| MAVS | Phosphorylation | S222 | 1.349 | 1.006 | _GPVS(ph)PSVSFQPLAR_ |
| MAVS | Ubiquitylation | K362 | 0.082 | _AGMVPSK(gl)VPTSMVLTK_ | |
| RIPK1 | Ubiquitylation | K642 | -0.431 | _EGIK(gl)GATVGK_ | |
| TRIM25 | Phosphorylation | S114 | -0.310 | -0.309 | _ASAPS(ph)PNAQVACDHCLK_ |
| TRIM25 | Ubiquitylation | K453 | 1.749 | _AK(gl)VLETFLAK_ |
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