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BIOCARTA_CASPASE_PATHWAY
(Pathway_965)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
LMNB1 2 -1.420 1.780 0.831 -0.150 0.195 1.319 0.831
PARP1 2
PARP1 2 -0.200 0.357 0.412 0.442 0.293
DFFA 2 -0.290 -0.220
CASP8 1 1.120 -1.090
LMNA 1 0.760 -0.400 1.025 -0.121 0.091 1.281 0.818
XIAP 0 0.600 -0.210
XIAP 0 0.600 -0.210 -1.128
CASP2 0 0.980 -1.120
BIRC2 0 -0.730 0.440
BIRC2 0 -0.730 0.440
CASP3 0 0.570 -0.390
CASP7 0 0.130 -0.130
DFFB 0 -0.200 -0.620
CYCS 0 -0.020 -0.350 0.711 0.320
LMNB2 0 -0.480 -0.180 0.912 1.309 0.829

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
BIRC2 Ubiquitylation K15 -0.259 0.307 _(ac)MEDSTILSDWTNSNK(gl)QK_
BIRC2 Ubiquitylation K17 -0.259 0.307 _(ac)MEDSTILSDWTNSNK(gl)QK_
BIRC2 Ubiquitylation K38 -0.069 _SIMEDSTILSDWTNSNKQK(gl)_
BIRC2 Ubiquitylation K102 -1.755 _LGDSPIQK(gl)HK_
BIRC2 Ubiquitylation K233 -0.511 _LSNWEPK(gl)DDAMSEHR_
BIRC2 Ubiquitylation K410 0.878 _DLVK(gl)QTVQSK_
BIRC2 Ubiquitylation K490 0.305 0.534 _ANVINK(gl)QEHDIIK_
BIRC2 Ubiquitylation K497 -1.934 _ANVINKQEHDIIK(gl)QK_
CASP2 Phosphorylation S340 -0.347 -1.529 _NHAGS(ph)PGCEESDAGKEK_
CASP3 Ubiquitylation K11 -0.053 -0.687 _(ac)MENTENSVDSK(gl)SIK_
CASP3 Ubiquitylation K14 -0.455 -0.687 _SIK(gl)NLEPK_
CASP3 Ubiquitylation K57 -0.304 -1.817 _NFHK(gl)STGMTSR_
CASP3 Ubiquitylation K82 -0.268 -0.605 _NLK(gl)YEVR_
CASP7 Phosphorylation S16 0.096 -0.112 _(ac)ADDQGCIEEQGVEDS(ph)ANEDSVDAKPDR_
CASP7 Ubiquitylation K80 0.580 -0.044 _NFDK(gl)VTGMGVR_
CASP8 Ubiquitylation K183 1.917 _IINDYEEFSK(gl)ER_
CASP8 Ubiquitylation K461 -2.031 _NMGK(gl)QMPQPTFTLR_
CYCS Ubiquitylation K40 -2.265 _K(gl)TGQAPGYSYTAANK(gl)NK_
CYCS Ubiquitylation K54 -0.872 -1.922 _K(gl)TGQAPGYSYTAANK(gl)NK_
CYCS Ubiquitylation K56 -0.872 -1.922 _TGQAPGYSYTAANKNK(gl)_
CYCS Ubiquitylation K101 -1.859 _ADLIAYLKK(gl)_
DFFA Phosphorylation S28 2.697 2.074 _NYS(ph)REQHGVAASCLEDLR_
DFFA Phosphorylation S37 -0.697 -0.347 _EQHGVAAS(ph)CLEDLR_
DFFA Ubiquitylation K208 -0.111 _EGSLLSK(gl)QEESK_
DFFA Phosphorylation S315 -0.237 -0.360 _AS(ph)PPGDLQNPK_
DFFB Ubiquitylation K176 -0.696 _FQSK(gl)SGYLR_
LMNA Phosphorylation T19 -1.262 _SGAQASST(ph)PLS(ph)PTR_
LMNA Phosphorylation S22 -0.433 0.377 _SGAQASST(ph)PLS(ph)PTR_
LMNA Ubiquitylation K32 0.054 _LQEK(gl)EDLQELNDR_
LMNA Ubiquitylation K78 -0.306 _EVSGIK(gl)AAYEAELGDAR_
LMNA Ubiquitylation K97 0.499 -0.167 _TLDSVAK(gl)ER_
LMNA Ubiquitylation K108 0.586 _LQLELSK(gl)VR_
LMNA Ubiquitylation K114 0.753 _VREEFK(gl)ELK_
LMNA Ubiquitylation K117 0.571 _VREEFKELK(gl)AR_
LMNA Ubiquitylation K122 0.401 _NTK(gl)KEGDLIAAQAR_
LMNA Ubiquitylation K123 0.401 _NTK(gl)KEGDLIAAQAR_
LMNA Ubiquitylation K135 0.856 1.129 _LK(gl)DLEALLNSK_
LMNA Ubiquitylation K155 -0.218 0.375 _EAALSTALSEK(gl)R_
LMNA Ubiquitylation K171 0.656 0.450 _GQVAK(gl)LEAALGEAKK_
LMNA Ubiquitylation K180 0.977 0.753 _LEAALGEAK(gl)K_
LMNA Ubiquitylation K181 0.458 0.679 _K(gl)QLQDEMLR_
LMNA Ubiquitylation K219 0.784 0.456 _NIYSEELRETK(gl)R_
LMNA Ubiquitylation K233 0.194 1.930 _LVEIDNGK(gl)QREFESR_
LMNA Ubiquitylation K261 0.576 _AQHEDQVEQYKK(gl)ELEK_
LMNA Ubiquitylation K265 0.532 0.714 _ELEK(gl)TYSAK_
LMNA Ubiquitylation K270 0.362 0.777 _TYSAK(gl)LDNAR_
LMNA Ubiquitylation K311 0.853 0.977 _IDSLSAQLSQLQK(gl)QLAAK_
LMNA Ubiquitylation K378 -0.030 0.701 _K(gl)LLEGEEER_
LMNA Phosphorylation S390 -0.020 -0.112 _LRLS(ph)PSPTSQR_
LMNA Phosphorylation S392 -0.062 -0.026 _LSPS(ph)PTSQR_
LMNA Phosphorylation S403 0.641 _GRAS(ph)SHSSQTQGGGSVTK_
LMNA Phosphorylation S458 0.520 _NKS(ph)NEDQSMGNWQIK_
LMNA Phosphorylation S632 0.730 _SVGGS(ph)GGGSFGDNLVTR_
LMNA Phosphorylation S636 0.537 1.498 _SVGGSGGGS(ph)FGDNLVTR_
LMNB1 Phosphorylation T19 -0.817 _AGGPT(ph)TPLS(ph)PTR_
LMNB1 Phosphorylation T20 1.745 1.653 _AGGPTT(ph)PLS(ph)PTR_
LMNB1 Phosphorylation S23 -1.433 -0.069 _AGGPTT(ph)PLS(ph)PTR_
LMNB1 Ubiquitylation K49 0.241 _LAVYIDK(gl)VR_
LMNB1 Ubiquitylation K102 0.735 _AK(gl)LQIELGK_
LMNB1 Ubiquitylation K109 1.002 1.397 _LQIELGK(gl)CK_
LMNB1 Ubiquitylation K111 0.960 1.074 _CK(gl)AEHDQLLLNYAK_
LMNB1 Ubiquitylation K124 0.616 _AEHDQLLLNYAKK(gl)_
LMNB1 Ubiquitylation K134 1.055 0.938 _ESDLNGAQIK(gl)LR_
LMNB1 Ubiquitylation K156 -0.626 _DAALATALGDK(gl)K_
LMNB1 Ubiquitylation K157 -0.626 _DAALATALGDK(gl)K_
LMNB1 Ubiquitylation K182 0.626 1.150 _K(gl)QLADETLLK_
LMNB1 Ubiquitylation K209 0.638 _K(gl)SMYEEEINETRR_
LMNB1 Ubiquitylation K271 -0.140 _EELEQTYHAK(gl)LENAR_
LMNB1 Ubiquitylation K312 0.657 0.597 _MRIESLSSQLSNLQK(gl)ESR_
LMNB1 Ubiquitylation K330 0.235 _IQELEDLLAK(gl)EKDNSR_
LMNB1 Ubiquitylation K332 0.657 _IQELEDLLAKEK(gl)_
LMNB1 Ubiquitylation K342 1.384 _MLTDK(gl)ER_
LMNB1 Ubiquitylation K379 0.041 0.701 _K(gl)LLEGEEERLK_
LMNB1 Ubiquitylation K389 -0.865 -0.244 _LK(gl)LSPSPSSR_
LMNB1 Phosphorylation S391 0.072 0.440 _LKLS(ph)PS(ph)PSSR_
LMNB1 Phosphorylation S393 -0.194 0.189 _LKLS(ph)PS(ph)PSSR_
LMNB1 Ubiquitylation K474 1.250 _K(gl)IGDTSVSYK_
LMNB1 Ubiquitylation K483 0.916 0.625 _IGDTSVSYK(gl)YTSR_
LMNB1 Ubiquitylation K532 0.805 1.201 _VILK(gl)NSQGEEVAQR_
LMNB1 Phosphorylation T548 -1.092 -0.823 _T(ph)TIPEEEEEEEEAAGVVVEEELFHQQGTPR_
LMNB1 Phosphorylation T549 -1.092 -0.823 _T(ph)TIPEEEEEEEEAAGVVVEEELFHQQGTPR_
LMNB1 Phosphorylation T575 -0.569 -0.468 _TTIPEEEEEEEEAAGVVVEEELFHQQGT(ph)PR_
LMNB2 Phosphorylation T14 -1.256 _AGGPAT(ph)PLS(ph)PTR_
LMNB2 Phosphorylation S17 -1.177 -0.088 _AGGPAT(ph)PLS(ph)PTR_
LMNB2 Ubiquitylation K61 0.704 0.753 _ISEK(gl)EEVTTR_
LMNB2 Ubiquitylation K103 0.917 1.128 _LQIEIGK(gl)LR_
LMNB2 Ubiquitylation K113 0.396 _AELDEVNK(gl)SAK_
LMNB2 Ubiquitylation K116 0.462 _AELDEVNKSAK(gl)_
LMNB2 Ubiquitylation K166 0.693 0.289 _AQLAK(gl)AEDGHAVAK_
LMNB2 Ubiquitylation K180 0.751 _QLEK(gl)ETLMR_
LMNB2 Ubiquitylation K265 0.078 1.270 _LELEQTYQAK(gl)LDSAK_
LMNB2 Ubiquitylation K270 -0.086 -0.261 _LDSAK(gl)LSSDQNDKAASAAR_
LMNB2 Ubiquitylation K278 0.240 0.830 _LSSDQNDK(gl)AASAAR_
LMNB2 Ubiquitylation K288 0.800 1.300 _EELK(gl)EAR_
LMNB2 Phosphorylation S399 1.142 0.767 _ATS(ph)SSSGSLSATGR_
LMNB2 Phosphorylation S400 1.015 0.953 _ATSS(ph)SSGSLSATGR_
LMNB2 Phosphorylation S402 1.194 _ATSSSS(ph)GSLSATGR_
LMNB2 Phosphorylation S404 1.103 _ATSSSSGS(ph)LSATGR_
LMNB2 Phosphorylation S406 0.617 _ATSSSSGSLS(ph)ATGR_
LMNB2 Ubiquitylation K474 0.084 _NNSDK(gl)DQSLGNWR_
LMNB2 Phosphorylation T498 0.866 _RQVLEGEEIAYKFT(ph)PK_
LMNB2 Ubiquitylation K500 0.029 0.094 _FTPK(gl)YILR_
PARP1 Phosphorylation S41 -0.803 _MAIMVQS(ph)PMFDGK_
PARP1 Ubiquitylation K84 1.223 _WDDQQK(gl)VK_
PARP1 Ubiquitylation K86 1.058 _VK(gl)KTAEAGGVTGK_
PARP1 Ubiquitylation K87 1.058 _VK(gl)KTAEAGGVTGK_
PARP1 Ubiquitylation K97 1.386 0.406 _TAEAGGVTGK(gl)GQDGIGSK_
PARP1 Ubiquitylation K105 0.828 _GQDGIGSK(gl)AEK_
PARP1 Ubiquitylation K108 1.317 _GQDGIGSKAEK(gl)_
PARP1 Ubiquitylation K119 1.569 _TLGDFAAEYAK(gl)SNR_
PARP1 Ubiquitylation K131 1.025 1.620 _GCMEK(gl)IEK_
PARP1 Ubiquitylation K197 0.445 1.157 _K(gl)QLPGVK_
PARP1 Ubiquitylation K254 0.589 _AQNDLIWNIKDELKK(gl)_
PARP1 Ubiquitylation K262 0.456 _VCSTNDLK(gl)ELLIFNK_
PARP1 Ubiquitylation K320 1.464 1.034 _SDAYYCTGDVTAWTK(gl)CMVK_
PARP1 Ubiquitylation K331 -0.425 -0.480 _TQTPNRK(gl)EWVTPK_
PARP1 Ubiquitylation K337 0.462 0.332 _EWVTPK(gl)EFR_
PARP1 Ubiquitylation K346 0.370 0.411 _EISYLK(gl)K_
PARP1 Phosphorylation T368 -1.474 -1.410 _IFPPETSASVAAT(ph)PPPSTASAPAAVNSSASADKPLSNM(ox)K_
PARP1 Ubiquitylation K400 0.844 1.095 _ILTLGK(gl)LSR_
PARP1 Ubiquitylation K414 1.227 1.241 _AMIEK(gl)LGGK_
PARP1 Ubiquitylation K418 1.131 _LGGK(gl)LTGTANK_
PARP1 Ubiquitylation K425 0.912 0.815 _LTGTANK(gl)ASLCISTKK_
PARP1 Ubiquitylation K433 0.942 _ASLCISTK(gl)K_
PARP1 Ubiquitylation K434 0.020 _ASLCISTKK(gl)_
PARP1 Ubiquitylation K447 1.480 _MEEVK(gl)EANIR_
PARP1 Ubiquitylation K518 0.108 _GQVKEEGINK(gl)SEK_
PARP1 Ubiquitylation K521 0.630 _GQVKEEGINKSEK(gl)R_
PARP1 Ubiquitylation K548 0.125 -0.480 _GGAAVDPDSGLEHSAHVLEK(gl)GGK_
PARP1 Ubiquitylation K551 0.492 -0.573 _GGAAVDPDSGLEHSAHVLEKGGK(gl)_
PARP1 Ubiquitylation K629 1.632 _TGNAWHSK(gl)NFTK_
PARP1 Ubiquitylation K633 0.964 0.091 _NFTK(gl)YPK_
PARP1 Ubiquitylation K654 -0.086 _K(gl)LTVNPGTK_
PARP1 Ubiquitylation K662 0.112 _LTVNPGTK(gl)SK_
PARP1 Ubiquitylation K664 -0.042 -0.111 _LTVNPGTKSK(gl)_
PARP1 Ubiquitylation K683 0.983 1.355 _MIFDVESM(ox)K(gl)K_
PARP1 Ubiquitylation K684 1.213 1.355 _MIFDVESMKK(gl)_
PARP1 Ubiquitylation K700 0.448 _MPLGK(gl)LSK_
PARP1 Phosphorylation S782 0.648 0.490 _GGS(ph)DDSSKDPIDVNYEK_
PARP1 Ubiquitylation K949 0.738 _HSVK(gl)GLGK_
XIAP Ubiquitylation K31 -0.312 -0.651 _LK(gl)TFANFPSGSPVSASTLAR_
XIAP Ubiquitylation K208 -0.788 -0.846 _LK(gl)NWEPCDR_
XIAP Ubiquitylation K358 -0.720 0.047 _TTEK(gl)TPSLTR_


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