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Query: XIAP

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
XIAP 0 -1.392 0.600 -0.210
XIAP 0 -1.392 0.600 -0.210 -1.128

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
XIAP Ubiquitylation K358 -0.720 0.047 _TTEK(gl)TPSLTR_
XIAP Ubiquitylation K31 -0.312 -0.651 _LK(gl)TFANFPSGSPVSASTLAR_
XIAP Ubiquitylation K208 -0.788 -0.846 _LK(gl)NWEPCDR_

Background Information for XIAP:


Pubmed-XIAP »
Uniprot-XIAP »
Biogrid-XIAP »
ProteomicsDB-XIAP »

Tumorportal-XIAP »
COSMIC-XIAP »
GenomeRNAi-XIAP »
Genecards-XIAP


Protein-protein Interactions for XIAP
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CKAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait CNOT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RANBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAPGEF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RNPS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait S100A4 Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMS Cat. description Hein, Mann, Cell 2015
Category members IP bait SORT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRPR Cat. description Hein, Mann, Cell 2015
Category members IP bait SUMO3 Cat. description Hein, Mann, Cell 2015
Category members IP bait UBE2A Cat. description Hein, Mann, Cell 2015
Category members IP bait ZBTB48 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADAMTS4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BIRC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BIRC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BIRC8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C19orf54 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CASP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLEC11A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DIABLO Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GMCL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PHB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRDX3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in XIAP
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BIR IPR001370 0.04
Category members Znf_RING IPR001841 0


Protein complexes (CORUM database) featuring XIAP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5317 LATS1-HTRA2-BIRC4 complex Database 0


Categories featuring XIAP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members Pathway Pathway_1053 KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0030510 regulation of BMP signaling pathway Database 0.09
Category members Disease phenotype X-linked_lymphoproliferative_disease X-linked lymphoproliferative disease Database 0.08
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process Database 0.05
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members Pathway Pathway_965 BIOCARTA_CASPASE_PATHWAY 0 0.01
Category members Pathway Pathway_1012 BIOCARTA_MITOCHONDRIA_PATHWAY 0 0
Category members Pathway Pathway_1020 BIOCARTA_DEATH_PATHWAY 0 0
Category members Pathway Pathway_1133 PID_BMP_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_544 BIOCARTA_BCELLSURVIVAL_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_959 SA_CASPASE_CASCADE 0 0
Category members Pathway Pathway_990 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS 0 0
Category members GO Category GO:0031398 positive regulation of protein ubiquitination Database 0
Category members GO Category GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0045088 regulation of innate immune response Database 0
Category members GO Category GO:0050727 regulation of inflammatory response Database 0
Category members GO Category GO:0055070 copper ion homeostasis Database 0
Category members GO Category GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway Database 0


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