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Query: CASP7

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CASP7 0 0.520 0.130 -0.130

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CASP7 Ubiquitylation K80 0.580 -0.044 _NFDK(gl)VTGMGVR_
CASP7 Phosphorylation S16 0.096 -0.112 _(ac)ADDQGCIEEQGVEDS(ph)ANEDSVDAKPDR_

Background Information for CASP7:


Pubmed-CASP7 »
Uniprot-CASP7 »
Biogrid-CASP7 »
ProteomicsDB-CASP7 »

Tumorportal-CASP7 »
COSMIC-CASP7 »
GenomeRNAi-CASP7 »
Genecards-CASP7


Protein-protein Interactions for CASP7
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in CASP7
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Pept_C14_ICE_p20 IPR001309 0.07
Category members Pept_C14_caspase IPR011600 0.07
Category members Pept_C14A_p45_core IPR015917 0.04
Category members Pept_C14_p10 IPR002138 0


Protein complexes (CORUM database) featuring CASP7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CASP7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_962 BIOCARTA_FAS_PATHWAY 0 1.75
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members GO Category GO:0009411 response to UV Database 0.79
Category members Pathway Pathway_956 BIOCARTA_DNAFRAGMENT_PATHWAY 0 0.62
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0016485 protein processing Database 0.57
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0004197 cysteine-type endopeptidase activity Database 0.38
Category members Pathway Pathway_964 BIOCARTA_CHEMICAL_PATHWAY 0 0.24
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members GO Category GO:0001836 release of cytochrome c from mitochondria Database 0.18
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members Pathway Pathway_1015 PID_HIV_NEF_PATHWAY 0 0.15
Category members Pathway Pathway_1018 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS 0 0.11
Category members Pathway Pathway_626 PID_A6B1_A6B4_INTEGRIN_PATHWAY 0 0.09
Category members Pathway Pathway_965 BIOCARTA_CASPASE_PATHWAY 0 0.01
Category members Pathway Pathway_1012 BIOCARTA_MITOCHONDRIA_PATHWAY 0 0
Category members Pathway Pathway_1020 BIOCARTA_DEATH_PATHWAY 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_544 BIOCARTA_BCELLSURVIVAL_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_959 SA_CASPASE_CASCADE 0 0
Category members Pathway Pathway_990 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS 0 0
Category members GO Category GO:0004190 aspartic-type endopeptidase activity Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0008234 cysteine-type peptidase activity Database 0
Category members GO Category GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Database 0
Category members GO Category GO:0043525 positive regulation of neuron apoptotic process Database 0


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