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Query: LMNB1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LMNB1 2 11.135 -1.420 1.780 0.831 -0.150 0.195 1.319 0.831

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LMNB1 Phosphorylation T20 1.745 1.653 _AGGPTT(ph)PLS(ph)PTR_
LMNB1 Ubiquitylation K109 1.002 1.397 _LQIELGK(gl)CK_
LMNB1 Ubiquitylation K532 0.805 1.201 _VILK(gl)NSQGEEVAQR_
LMNB1 Ubiquitylation K182 0.626 1.150 _K(gl)QLADETLLK_
LMNB1 Ubiquitylation K111 0.960 1.074 _CK(gl)AEHDQLLLNYAK_
LMNB1 Ubiquitylation K134 1.055 0.938 _ESDLNGAQIK(gl)LR_
LMNB1 Ubiquitylation K379 0.041 0.701 _K(gl)LLEGEEERLK_
LMNB1 Ubiquitylation K332 0.657 _IQELEDLLAKEK(gl)_
LMNB1 Ubiquitylation K483 0.916 0.625 _IGDTSVSYK(gl)YTSR_
LMNB1 Ubiquitylation K312 0.657 0.597 _MRIESLSSQLSNLQK(gl)ESR_
LMNB1 Phosphorylation S391 0.072 0.440 _LKLS(ph)PS(ph)PSSR_
LMNB1 Phosphorylation S393 -0.194 0.189 _LKLS(ph)PS(ph)PSSR_
LMNB1 Phosphorylation S23 -1.433 -0.069 _AGGPTT(ph)PLS(ph)PTR_
LMNB1 Ubiquitylation K389 -0.865 -0.244 _LK(gl)LSPSPSSR_
LMNB1 Phosphorylation T575 -0.569 -0.468 _TTIPEEEEEEEEAAGVVVEEELFHQQGT(ph)PR_
LMNB1 Phosphorylation T19 -0.817 _AGGPT(ph)TPLS(ph)PTR_
LMNB1 Phosphorylation T548 -1.092 -0.823 _T(ph)TIPEEEEEEEEAAGVVVEEELFHQQGTPR_
LMNB1 Phosphorylation T549 -1.092 -0.823 _T(ph)TIPEEEEEEEEAAGVVVEEELFHQQGTPR_
LMNB1 Ubiquitylation K49 0.241 _LAVYIDK(gl)VR_
LMNB1 Ubiquitylation K102 0.735 _AK(gl)LQIELGK_
LMNB1 Ubiquitylation K124 0.616 _AEHDQLLLNYAKK(gl)_
LMNB1 Ubiquitylation K156 -0.626 _DAALATALGDK(gl)K_
LMNB1 Ubiquitylation K157 -0.626 _DAALATALGDK(gl)K_
LMNB1 Ubiquitylation K209 0.638 _K(gl)SMYEEEINETRR_
LMNB1 Ubiquitylation K271 -0.140 _EELEQTYHAK(gl)LENAR_
LMNB1 Ubiquitylation K330 0.235 _IQELEDLLAK(gl)EKDNSR_
LMNB1 Ubiquitylation K342 1.384 _MLTDK(gl)ER_
LMNB1 Ubiquitylation K474 1.250 _K(gl)IGDTSVSYK_

Background Information for LMNB1:


Pubmed-LMNB1 »
Uniprot-LMNB1 »
Biogrid-LMNB1 »
ProteomicsDB-LMNB1 »

Tumorportal-LMNB1 »
COSMIC-LMNB1 »
GenomeRNAi-LMNB1 »
Genecards-LMNB1


Protein-protein Interactions for LMNB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HNRNPF Cat. description Hein, Mann, Cell 2015
Category members IP bait KPNA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LMNA Cat. description Hein, Mann, Cell 2015
Category members IP bait NCSTN Cat. description Hein, Mann, Cell 2015
Category members IP bait NES Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM63B Cat. description Hein, Mann, Cell 2015
Category members IP bait TMPO Cat. description Hein, Mann, Cell 2015
Category members IP bait GNAI2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LMNB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Lamin_tail_dom IPR001322 0.9
Category members IF IPR001664 0


Protein complexes (CORUM database) featuring LMNB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5614 Emerin complex 32 Database 1.48
Category members Corum 5611 Emerin complex 24 Database 1.05
Category members Corum 5615 Emerin complex 52 Database 0.99
Category members Corum 5608 Emerin architectural complex Database 0.15
Category members Corum 5613 Emerin complex 25 Database 0.04


Categories featuring LMNB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005637 nuclear inner membrane Database 1.98
Category members Pathway Pathway_962 BIOCARTA_FAS_PATHWAY 0 1.75
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members GO Category GO:0005638 lamin filament Database 0.89
Category members Pathway Pathway_963 BIOCARTA_TNFR1_PATHWAY 0 0.44
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members Pathway Pathway_965 BIOCARTA_CASPASE_PATHWAY 0 0.01
Category members GO Category GO:0005882 intermediate filament Database 0
Category members GO Category GO:0043274 phospholipase binding Database 0


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